YRC Public Data Repository - Protein Structure Prediction

Protein:	CAB3
Organism:	Saccharomyces cerevisiae
Length:	571 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CAB3.

Description	E-value	Query Range	Subject Range
CAB3 - Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which c... CAB3_YEAST - Coenzyme A biosynthesis protein 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CAB3 P... gi\|190409742 - gi\|190409742\|gb\|EDV13007.1\| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]	0.0	[1..571]	[1..571]
gi\|2983357, gi\|1... - gi\|2983357\|gb\|AAC06944.1\| pantothenate metabolism flavoprotein [Aquifex aeolicus VF5], gi\|15606181\|r... gi\|7449265 - pir\|\|B70371 pantothenate metabolism flavoprotein dfp - Aquifex aeolicus	5.0E-67	[309..526]	[1..202]
gi\|14023511, gi\|... - gi\|14023511\|dbj\|BAB50117.1\| pantothenate metabolism flavoprotein [Mesorhizobium loti MAFF303099], gi...	1.0E-65	[279..526]	[6..236]
gi\|11279829 - pir\|\|A81058 DNA/pantothenate metabolism flavoprotein NMB1658 [imported] - Neisseria meningitidis (st... gi\|15677507, gi\|... - gi\|7226910\|gb\|AAF42007.1\| phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine li...	2.0E-65	[308..527]	[2..207]
gi\|15978163, gi\|... - gi\|16120401\|ref\|NP_403714.1\| phosphopantothenoylcysteine synthase/decarboxylase [Yersinia pestis CO9... gi\|150260888, gi... - gi\|150260888\|ref\|ZP_01917616.1\| DNA/pantothenate metabolism flavoprotein [Yersinia pestis CA88-4125]... gi\|51594403, gi\|... - gi\|51594403\|ref\|YP_068594.1\| phosphopantothenoylcysteine synthase/decarboxylase [Yersinia pseudotube... Q66GD7\|Q66GD7_YERPS - DNA/pantothenate metabolism flavoprotein - Yersinia pseudotuberculosis gi\|165936230, gi... - gi\|165936230\|ref\|ZP_02224799.1\| phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cyste... gi\|45434769, gi\|... - gi\|45439914\|ref\|NP_991453.1\| phosphopantothenoylcysteine synthase/decarboxylase [Yersinia pestis bio... gi\|25322282 - pir\|\|AI0006 DNA/pantothenate metabolism flavoprotein [imported] - Yersinia pestis (strain CO92)	2.0E-65	[302..526]	[1..212]
TYSY_SCHPO - Probable thymidylate synthase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC15E1.04 ... SPAC15E1.04 - thymidylate synthase	4.0E-65	[271..543]	[2..244]
gi\|11279828 - pir\|\|D81819 hypothetical protein NMA1916 [imported] - Neisseria meningitidis (strain Z2491 serogroup... gi\|15794801, gi\|... - gi\|7380550\|emb\|CAB85137.1\| hypothetical protein [Neisseria meningitidis Z2491], gi\|218768681\|ref\|YP_...	4.0E-64	[308..526]	[2..206]
gi\|17132205, gi\|... - gi\|17230603\|ref\|NP_487151.1\| bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothen... gi\|25322296 - pir\|\|AH2194 pantothenate metabolism flavoprotein [imported] - Nostoc sp. (strain PCC 7120)	8.0E-64	[298..526]	[2..221]
gi\|15964111 - gi\|15964111\|ref\|NP_384464.1\| bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothen... gi\|15073287 - gi\|15073287\|emb\|CAC41795.1\| Probable coenzyme A biosynthesis bifunctional protein CoaBC : Phosphopan...	1.0E-63	[306..526]	[3..211]

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Predicted Domain #1

Region A:
Residues: [1-275]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDEKVNSDQ NMNGKQGVNL ISSLPTTQVP VSILTNKERR KSIHDESNFE RSDSHEDQSK  60
   61 SNSNRRNIYK NDYSTNLRDF SFANLKQNSE RNKDGHEIQI NTSMPANTNG QQKRFSPSLP 120
  121 SAVSFTVPEV ERLPYHRYSI SNKPGKQQQQ QEQLQQNQQQ EEQQKAQLQE QNQRAKQQEE 180
  181 VKQIQEQVQK KQTERQQLID EKERIANAIF KENTTNDGTD IRKHSVSSGT SNSEDEVDSP 240
  241 SMEKNSIVHM PGDFIYFNPK SNASKPITAK AAPLS

[Run NCBI BLAST on this sequence.]

Detection Method:	Pcons
Confidence:	1.58
Match:	1c1gB
Description:	Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [276-571]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANNSTHKNKE VITAPTGPRV PFTEFFQKED DKKFHILIGA TGSVATIKVP LIIDKLFKIY  60
   61 GPEKISIQLI VTKPAEHFLK GLKMSTHVKI WREEDAWVFD AVNKNDTSLS LNLILHHELR 120
  121 KWADIFLIAP LSANTLAKLA NGICNNLLTS VMRDWSPLTP VLIAPAMNTF MYINPMTKKH 180
  181 LTSLVQDYPF IQVLKPVEKV LICGDIGMGG MREWTDIVEI VRRRINEIRK ARDEETGDKE 240
  241 QEQEEQEGAD NEDDDDEDDE EDEEDEEEEE ALNETASDES NDEEDEEDEE DVKTEV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	405.228787
Match:	1e20A_
Description:	4'-phosphopantothenoylcysteine decarboxylase (PPC decarboxylase, halotolerance protein Hal3a)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphopantothenoylcysteine decarboxylase activity	3.86093811191169	bayes_pls_golite062009
phosphopantothenate--cysteine ligase activity	2.64345867885176	bayes_pls_golite062009
carboxy-lyase activity	1.79168084682693	bayes_pls_golite062009
catalytic activity	1.51672397362026	bayes_pls_golite062009
carbon-carbon lyase activity	1.03827559540394	bayes_pls_golite062009
binding	0.954975261385974	bayes_pls_golite062009
protein binding	0.259532204752794	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: