YRC Public Data Repository - Protein Structure Prediction

Protein:	FBA1
Organism:	Saccharomyces cerevisiae
Length:	359 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBA1.

Description	E-value	Query Range	Subject Range
ALF_YEAST - Fructose-bisphosphate aldolase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FBA1 PE=1... FBA1 - Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversio...	0.0	[1..359]	[1..359]
ALF_EDWIC - Fructose-bisphosphate aldolase OS=Edwardsiella ictaluri GN=fba PE=3 SV=1 gi\|2708661\|gb\|AA... - fructose 1,6-bisphosphate aldolase [Edwardsiella ictaluri]	0.0	[10..359]	[9..358]
gi\|12722289, gi\|... - gi\|15603726\|ref\|NP_246800.1\| fructose-bisphosphate aldolase [Pasteurella multocida subsp. multocida ...	0.0	[3..359]	[4..359]
ALF_HAEIN - Fructose-bisphosphate aldolase OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)... ALF_HAEIN - Fructose-bisphosphate aldolase OS=Haemophilus influenzae GN=fba PE=3 SV=1	0.0	[3..359]	[4..359]
gi\|229525169, gi... - gi\|229525169\|ref\|ZP_04414574.1\| fructose-bisphosphate aldolase class II [Vibrio cholerae bv. albensi... gi\|229530320, gi... - gi\|229530320\|ref\|ZP_04419708.1\| fructose-bisphosphate aldolase class II [Vibrio cholerae 12129(1)], ... gi\|15640505, gi\|... - gi\|9654905\|gb\|AAF93651.1\| fructose-bisphosphate aldolase, class II [Vibrio cholerae O1 biovar El Tor... gi\|229368883, gi... - gi\|229606228\|ref\|YP_002876876.1\| fructose-bisphosphate aldolase class II [Vibrio cholerae MJ-1236], ... gi\|11268101 - pir\|\|G82317 fructose-bisphosphate aldolase, class II VC0478 [imported] - Vibrio cholerae (strain N16... gi\|125618167, gi... - gi\|75829965\|ref\|ZP_00759253.1\| COG0191: Fructose/tagatose bisphosphate aldolase [Vibrio cholerae MO1... gi\|147674645, gi... - gi\|75825879\|ref\|ZP_00755314.1\| COG0191: Fructose/tagatose bisphosphate aldolase [Vibrio cholerae O39... gi\|116216306, gi... - gi\|75822652\|ref\|ZP_00752239.1\| COG0191: Fructose/tagatose bisphosphate aldolase [Vibrio cholerae RC3... gi\|254226301, gi... - gi\|75818761\|ref\|ZP_00748887.1\| COG0191: Fructose/tagatose bisphosphate aldolase [Vibrio cholerae V51... gi\|75815152, gi\|... - gi\|75815152\|ref\|ZP_00745676.1\| COG0191: Fructose/tagatose bisphosphate aldolase [Vibrio cholerae V52... gi\|150422884, gi... - gi\|254291190\|ref\|ZP_04961986.1\| fructose-bisphosphate aldolase, class II [Vibrio cholerae AM-19226],... gi\|153828400, gi... - gi\|153828400\|ref\|ZP_01981067.1\| fructose-bisphosphate aldolase, class II [Vibrio cholerae 623-39], g... gi\|149739634, gi... - gi\|153826542\|ref\|ZP_01979209.1\| fructose-bisphosphate aldolase, class II [Vibrio cholerae MZO-2], gi... gi\|121591109, gi... - gi\|121591109\|ref\|ZP_01678419.1\| fructose-bisphosphate aldolase, class II [Vibrio cholerae 2740-80], ... gi\|124113515, gi... - gi\|153217542\|ref\|ZP_01951223.1\| fructose-bisphosphate aldolase, class II [Vibrio cholerae 1587], gi\|... gi\|153223769, gi... - gi\|153223769\|ref\|ZP_01954056.1\| fructose-bisphosphate aldolase, class II [Vibrio cholerae MAK 757], ... gi\|124122978, gi... - gi\|153801487\|ref\|ZP_01956073.1\| fructose-bisphosphate aldolase, class II [Vibrio cholerae MZO-3], gi... gi\|153819448, gi... - gi\|153819448\|ref\|ZP_01972115.1\| fructose-bisphosphate aldolase, class II [Vibrio cholerae NCTC 8457]... gi\|229509047, gi... - gi\|229509047\|ref\|ZP_04398535.1\| fructose-bisphosphate aldolase class II [Vibrio cholerae B33], gi\|22... gi\|227080688, gi... - gi\|227080688\|ref\|YP_002809239.1\| fructose-bisphosphate aldolase, class II [Vibrio cholerae M66-2], g... gi\|229355862, gi... - gi\|229507117\|ref\|ZP_04396623.1\| fructose-bisphosphate aldolase class II [Vibrio cholerae BX 330286],... gi\|229512539, gi... - gi\|229512539\|ref\|ZP_04402010.1\| fructose-bisphosphate aldolase class II [Vibrio cholerae TMA 21], gi... gi\|229344404, gi... - gi\|229519715\|ref\|ZP_04409158.1\| fructose-bisphosphate aldolase class II [Vibrio cholerae RC9], gi\|22... gi\|229520789, gi... - gi\|229520789\|ref\|ZP_04410211.1\| fructose-bisphosphate aldolase class II [Vibrio cholerae TM 11079-80...	0.0	[10..359]	[9..358]
gi\|25291095 - gi\|25291095\|pir\|\|G85948 fructose-bisphosphate aldolase, class II [imported] - Escherichia coli (stra... gi\|12517457, gi\|... - gi\|15803459\|ref\|NP_289492.1\| fructose-bisphosphate aldolase [Escherichia coli O157:H7 EDL933], gi\|12...	0.0	[10..359]	[34..384]
gi\|115346704, gi... - gi\|218928093\|ref\|YP_002345968.1\| fructose-bisphosphate aldolase [Yersinia pestis CO92], gi\|16121225\|... gi\|165937243, gi... - gi\|89104325\|ref\|ZP_01176871.1\| COG0191: Fructose/tagatose bisphosphate aldolase [Yersinia pestis bio... gi\|108806341, gi... - gi\|108806341\|ref\|YP_650257.1\| fructose-bisphosphate aldolase [Yersinia pestis Antiqua], gi\|108778254... gi\|229690916, gi... - gi\|229842606\|ref\|ZP_04462761.1\| fructose-bisphosphate aldolase, class II [Yersinia pestis biovar Ori... gi\|229697200, gi... - gi\|229840834\|ref\|ZP_04460993.1\| fructose-bisphosphate aldolase, class II [Yersinia pestis biovar Ori... gi\|229837610, gi... - gi\|229837610\|ref\|ZP_04457772.1\| fructose-bisphosphate aldolase, class II [Yersinia pestis Pestoides ... gi\|108776927, gi... - gi\|229903738\|ref\|ZP_04518851.1\| fructose-bisphosphate aldolase, class II [Yersinia pestis Nepal516],... gi\|165990778, gi... - gi\|166010292\|ref\|ZP_02231190.1\| fructose-bisphosphate aldolase, class II [Yersinia pestis biovar Ant... gi\|166205963, gi... - gi\|166212671\|ref\|ZP_02238706.1\| fructose-bisphosphate aldolase, class II [Yersinia pestis biovar Ant... gi\|167050763, gi... - gi\|167400055\|ref\|ZP_02305573.1\| fructose-bisphosphate aldolase, class II [Yersinia pestis biovar Ant... gi\|166962784, gi... - gi\|167418790\|ref\|ZP_02310543.1\| fructose-bisphosphate aldolase, class II [Yersinia pestis biovar Ori... gi\|167425361, gi... - gi\|167425361\|ref\|ZP_02317114.1\| fructose-bisphosphate aldolase, class II [Yersinia pestis biovar Med... gi\|169749636, gi... - gi\|170023102\|ref\|YP_001719607.1\| fructose-bisphosphate aldolase [Yersinia pseudotuberculosis YPIII],... gi\|145209596, gi... - gi\|145597900\|ref\|YP_001161976.1\| fructose-bisphosphate aldolase [Yersinia pestis Pestoides F], gi\|14... gi\|149290684, gi... - gi\|149367070\|ref\|ZP_01889103.1\| fructose-bisphosphate aldolase class II [Yersinia pestis CA88-4125],... gi\|25291105 - pir\|\|AI0112 fructose-bisphosphate aldolase (EC 4.1.2.13) [imported] - Yersinia pestis (strain CO92) gi\|45438126, gi\|... - gi\|45443258\|ref\|NP_994797.1\| fructose-bisphosphate aldolase [Yersinia pestis biovar Microtus str. 91... gi\|77635848, gi\|... - gi\|77635848\|ref\|ZP_00797928.1\| COG0191: Fructose/tagatose bisphosphate aldolase [Yersinia pestis Ang... gi\|22127183, gi\|... - gi\|22127183\|ref\|NP_670606.1\| fructose-bisphosphate aldolase [Yersinia pestis KIM], gi\|21960247\|gb\|AA... gi\|117672603, gi... - gi\|77630172\|ref\|ZP_00792758.1\| COG0191: Fructose/tagatose bisphosphate aldolase [Yersinia pseudotube... gi\|165923161, gi... - gi\|165924961\|ref\|ZP_02220793.1\| fructose-bisphosphate aldolase, class II [Yersinia pestis biovar Ori...	0.0	[10..359]	[9..359]
ALF_ECOLI - (P0AB71) Fructose-bisphosphate aldolase class 2 (EC 4.1.2.13) (Fructose-bisphosphate aldolase class ... ALF_ECO57 - (P0AB72) Fructose-bisphosphate aldolase class 2 (EC 4.1.2.13) (Fructose-bisphosphate aldolase class ... ALF_SHIFL - (P0AB73) Fructose-bisphosphate aldolase class 2 (EC 4.1.2.13) (Fructose-bisphosphate aldolase class ...	0.0	[10..359]	[8..358]
EG10282 - fructose-bisphosphate aldolase, class II / Fructose 1,6-bisphosphate aldolase, class II; binds Zn(II... gi\|124526171, gi... - gi\|124526171\|ref\|ZP_01698176.1\| fructose-bisphosphate aldolase, class II [Escherichia coli B], gi\|12... gi\|188017950, gi... - gi\|188017950\|gb\|EDU56072.1\| fructose-bisphosphate aldolase [Escherichia coli O157:H7 str. EC4113], g... gi\|161367532 - gi\|161367532\|ref\|NP_289492.2\| fructose-bisphosphate aldolase [Escherichia coli O157:H7 EDL933] gi\|168760056, gi... - gi\|189369276\|gb\|EDU87692.1\| fructose-bisphosphate aldolase [Escherichia coli O157:H7 str. EC4501], g... gi\|168753866, gi... - gi\|189358623\|gb\|EDU77042.1\| fructose-bisphosphate aldolase [Escherichia coli O157:H7 str. EC4401], g... gi\|229774936 - gi\|229774936\|ref\|YP_690345.2\| fructose-bisphosphate aldolase [Shigella flexneri 5 str. 8401] gi\|168773446, gi... - gi\|187770951\|gb\|EDU34795.1\| fructose-bisphosphate aldolase [Escherichia coli O157:H7 str. EC4196], g... gi\|238902048, gi... - gi\|238902048\|ref\|YP_002927844.1\| fructose-bisphosphate aldolase, class II [Escherichia coli BW2952],... gi\|189363778, gi... - gi\|189363778\|gb\|EDU82197.1\| fructose-bisphosphate aldolase [Escherichia coli O157:H7 str. EC4486], g... gi\|253978903, gi... - gi\|254289596\|ref\|YP_003055344.1\| fructose-bisphosphate aldolase [Escherichia coli BL21(DE3)], gi\|253... gi\|168785772, gi... - gi\|189373914\|gb\|EDU92330.1\| fructose-bisphosphate aldolase [Escherichia coli O157:H7 str. EC869], gi... gi\|254162836, gi... - gi\|254162836\|ref\|YP_003045944.1\| fructose-bisphosphate aldolase [Escherichia coli B str. REL606], gi... gi\|189000598, gi... - gi\|189000598\|gb\|EDU69584.1\| fructose-bisphosphate aldolase [Escherichia coli O157:H7 str. EC4076], g... gi\|254594272, gi... - gi\|254794872\|ref\|YP_003079709.1\| fructose-bisphosphate aldolase, class II [Escherichia coli O157:H7 ... gi\|209913639, gi... - gi\|209920380\|ref\|YP_002294464.1\| fructose-bisphosphate aldolase [Escherichia coli SE11], gi\|20991363... gi\|209159168, gi... - gi\|209397768\|ref\|YP_002272399.1\| fructose-bisphosphate aldolase [Escherichia coli O157:H7 str. EC411... gi\|218357708, gi... - gi\|218550167\|ref\|YP_002383958.1\| fructose-bisphosphate aldolase [Escherichia fergusonii ATCC 35469],... gi\|217320258, gi... - gi\|217327891\|ref\|ZP_03443974.1\| fructose-bisphosphate aldolase [Escherichia coli O157:H7 str. TW1458... gi\|218696518, gi... - gi\|218696518\|ref\|YP_002404185.1\| fructose-bisphosphate aldolase [Escherichia coli 55989], gi\|2183532... gi\|218555473, gi... - gi\|218555473\|ref\|YP_002388386.1\| fructose-bisphosphate aldolase [Escherichia coli IAI1], gi\|21836224... gi\|218706433, gi... - gi\|218706433\|ref\|YP_002413952.1\| fructose-bisphosphate aldolase [Escherichia coli UMN026], gi\|218433... gi\|218701631, gi... - gi\|218701631\|ref\|YP_002409260.1\| fructose-bisphosphate aldolase [Escherichia coli IAI39], gi\|2183716... gi\|170018830, gi... - gi\|170018830\|ref\|YP_001723784.1\| fructose-bisphosphate aldolase [Escherichia coli ATCC 8739], gi\|169... gi\|189379624, gi... - gi\|189379624\|gb\|EDU98040.1\| fructose-bisphosphate aldolase [Escherichia coli O157:H7 str. EC508], gi... gi\|170681392, gi... - gi\|170681392\|ref\|YP_001745082.1\| fructose-bisphosphate aldolase [Escherichia coli SMS-3-5], gi\|17051... gi\|170082482, gi... - gi\|170082482\|ref\|YP_001731802.1\| fructose-bisphosphate aldolase, class II [Escherichia coli str. K-1... gi\|208725804, gi... - gi\|208806003\|ref\|ZP_03248340.1\| fructose-bisphosphate aldolase [Escherichia coli O157:H7 str. EC4206... gi\|195936541 - gi\|195936541\|ref\|ZP_03081923.1\| fructose-bisphosphate aldolase [Escherichia coli O157:H7 str. EC4024... gi\|208821944, gi... - gi\|208821944\|ref\|ZP_03262264.1\| fructose-bisphosphate aldolase [Escherichia coli O157:H7 str. EC4042... gi\|208735338, gi... - gi\|208814061\|ref\|ZP_03255390.1\| fructose-bisphosphate aldolase [Escherichia coli O157:H7 str. EC4045... gi\|15833050, gi\|... - gi\|15833050\|ref\|NP_311823.1\| fructose-bisphosphate aldolase [Escherichia coli O157:H7 str. Sakai], g... gi\|56480206, gi\|... - gi\|56480206\|ref\|NP_708685.2\| fructose-bisphosphate aldolase [Shigella flexneri 2a str. 301], gi\|5638... gi\|75239508, gi\|... - gi\|75239508\|ref\|ZP_00723479.1\| COG0191: Fructose/tagatose bisphosphate aldolase [Escherichia coli E1... gi\|75258524, gi\|... - gi\|75258524\|ref\|ZP_00729946.1\| COG0191: Fructose/tagatose bisphosphate aldolase [Escherichia coli E2... gi\|194415568, gi... - gi\|75212462\|ref\|ZP_00712486.1\| COG0191: Fructose/tagatose bisphosphate aldolase [Escherichia coli B1... gi\|191168205, gi... - gi\|75228592\|ref\|ZP_00715221.1\| COG0191: Fructose/tagatose bisphosphate aldolase [Escherichia coli B7... gi\|81242460, gi\|... - gi\|82778312\|ref\|YP_404661.1\| fructose-bisphosphate aldolase [Shigella dysenteriae Sd197], gi\|8124246... gi\|89109703, gi\|... - gi\|89109703\|ref\|AP_003483.1\| fructose-bisphosphate aldolase, class II [Escherichia coli str. K-12 su... gi\|188492662, gi... - gi\|75515291\|ref\|ZP_00737475.1\| COG0191: Fructose/tagatose bisphosphate aldolase [Escherichia coli 53... gi\|74313481, gi\|... - gi\|74313481\|ref\|YP_311900.1\| fructose-bisphosphate aldolase [Shigella sonnei Ss046], gi\|73856958\|gb\|... ALF_SHIFL - Fructose-bisphosphate aldolase class 2 OS=Shigella flexneri GN=fbaA PE=3 SV=2 ALF_ECOLI - Fructose-bisphosphate aldolase class 2 (EC 4.1.2.13) (Fructose-bisphosphate aldolase class II) (FBP ... gi\|30064233, gi\|... - gi\|30064233\|ref\|NP_838404.1\| fructose-bisphosphate aldolase [Shigella flexneri 2a str. 2457T], gi\|30... gi\|157156893, gi... - gi\|75187640\|ref\|ZP_00700907.1\| COG0191: Fructose/tagatose bisphosphate aldolase [Escherichia coli E2... ALF_ECO57 - Fructose-bisphosphate aldolase class 2 OS=Escherichia coli O157:H7 GN=fbaA PE=3 SV=2 gi\|157068064, gi... - gi\|75196876\|ref\|ZP_00706946.1\| COG0191: Fructose/tagatose bisphosphate aldolase [Escherichia coli HS... EG10282 - fructose-bisphosphate aldolase, class II / Fructose 1,6-bisphosphate aldolase, class II; binds Zn(II... gi\|83587680, gi\|... - gi\|83587680\|ref\|ZP_00926307.1\| COG0191: Fructose/tagatose bisphosphate aldolase [Escherichia coli 10...	0.0	[10..359]	[9..359]

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Predicted Domain #1

Region A:
Residues: [1-359]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVEQILKRK TGVIVGEDVH NLFTYAKEHK FAIPAINVTS SSTAVAALEA ARDSKSPIIL  60
   61 QTSNGGAAYF AGKGISNEGQ NASIKGAIAA AHYIRSIAPA YGIPVVLHSD HCAKKLLPWF 120
  121 DGMLEADEAY FKEHGEPLFS SHMLDLSEET DEENISTCVK YFKRMAAMDQ WLEMEIGITG 180
  181 GEEDGVNNEN ADKEDLYTKP EQVYNVYKAL HPISPNFSIA AAFGNCHGLY AGDIALRPEI 240
  241 LAEHQKYTRE QVGCKEEKPL FLVFHGGSGS TVQEFHTGID NGVVKVNLDT DCQYAYLTGI 300
  301 RDYVLNKKDY IMSPVGNPEG PEKPNKKFFD PRVWVREGEK TMGAKITKSL ETFRTTNTL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1114.0
Match:	1dosA_
Description:	Fructose-bisphosphate aldolase (FBP aldolase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	2.67031204377352	bayes_pls_golite062009
fructose-bisphosphate aldolase activity	2.5119145652386	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	2.0240718059985	bayes_pls_golite062009
transaldolase activity	1.66628808988861	bayes_pls_golite062009
binding	1.1388634428163	bayes_pls_golite062009
lyase activity	0.740424046054758	bayes_pls_golite062009
transferase activity	0.464721888799972	bayes_pls_golite062009
aldehyde-lyase activity	0.351872954170322	bayes_pls_golite062009
signal transducer activity	0.348681535897548	bayes_pls_golite062009
molecular transducer activity	0.348681535897548	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	0.25728790872659	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: