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View Structure Prediction Details

Protein: TAH11
Organism: Saccharomyces cerevisiae
Length: 604 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TAH11.

Description E-value Query
Range
Subject
Range
TAH11 - DNA replication licensing factor, required for pre-replication complex assembly
CDT1_YEAST - Cell division cycle protein CDT1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TAH11 P...
0.0 [1..604] [1..604]

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Predicted Domain #1
Region A:
Residues: [1-604]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGTANSRRK EVLRVPVIDL NRVSDEEQLL PVVRAILLQH DTFLLKNYAN KAVLDALLAG  60
   61 LTTKDLPDTS QGFDANFTGT LPLEDDVWLE QYIFDTDPQL RFDRKCRNES LCSIYSRLFK 120
  121 LGLFFAQLCV KSVVSSAELQ DCISTSHYAT KLTRYFNDNG STHDGADAGA TVLPTGDDFQ 180
  181 YLFERDYVTF LPTGVLTIFP CAKAIRYKPS TMATTDNSWV SIDEPDCLLF HTGTLLARWS 240
  241 QGMHTTSPLQ IDPRANIVSL TIWPPLTTPI SSKGEGTIAN HLLEQQIKAF PKVAQQYYPR 300
  301 ELSILRLQDA MKFVKELFTV CETVLSLNAL SRSTGVPPEL HVLLPQISSM MKRKIVQDDI 360
  361 LKLLTIWSDA YVVELNSRGE LTMNLPKRDN LTTLTNKSRT LAFVERAESW YQQVIASKDE 420
  421 IMTDVPAFKI NKRRSSSNSK TVLSSKVQTK SSNANALNNS RYLANSKENF MYKEKMPDSQ 480
  481 ANLMDRLRER ERRSAALLSQ RQKRYQQFLA MKMTQVFDIL FSLTRGQPYT ETYLSSLIVD 540
  541 SLQDSNNPIG TKEASEILAG LQGILPMDIS VHQVDGGLKV YRWNSLDKNR FSKLLQIHKS 600
  601 KQQD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
DNA binding 2.33472544234344 bayes_pls_golite062009
damaged DNA binding 2.29845214826196 bayes_pls_golite062009
nucleic acid binding 2.22897758853097 bayes_pls_golite062009
binding 1.98369242373199 bayes_pls_golite062009
catalytic activity 0.870891682911347 bayes_pls_golite062009
exonuclease activity 0.690474252448043 bayes_pls_golite062009
protein binding 0.318595689949854 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [332-457]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RSTGVPPELH VLLPQISSMM KRKIVQDDIL KLLTIWSDAY VVELNSRGEL TMNLPKRDNL  60
   61 TTLTNKSRTL AFVERAESWY QQVIASKDEI MTDVPAFKIN KRRSSSNSKT VLSSKVQTKS 120
  121 SNANAL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.44
Match: 1wlqC
Description: Strucure of Geminin-Cdt1 complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.98098149944065 bayes_pls_golite062009
DNA binding 4.60314587965928 bayes_pls_golite062009
nucleic acid binding 4.41560500044233 bayes_pls_golite062009
transcription factor activity 3.83751005834021 bayes_pls_golite062009
binding 3.37660003833383 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.84400558797599 bayes_pls_golite062009
sequence-specific DNA binding 2.21432668306508 bayes_pls_golite062009
transcription activator activity 2.05647866476552 bayes_pls_golite062009
transcription repressor activity 1.93634276716466 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.28362954833504 bayes_pls_golite062009
structure-specific DNA binding 0.815066484495067 bayes_pls_golite062009
transcription factor binding 0.732240481554495 bayes_pls_golite062009
protein binding 0.726445167461826 bayes_pls_golite062009
nucleotidyltransferase activity 0.437617796040738 bayes_pls_golite062009
ligase activity 0.11359254431153 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [458-604]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNSRYLANSK ENFMYKEKMP DSQANLMDRL RERERRSAAL LSQRQKRYQQ FLAMKMTQVF  60
   61 DILFSLTRGQ PYTETYLSSL IVDSLQDSNN PIGTKEASEI LAGLQGILPM DISVHQVDGG 120
  121 LKVYRWNSLD KNRFSKLLQI HKSKQQD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle