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View Structure Prediction Details

Protein: NUP85
Organism: Saccharomyces cerevisiae
Length: 744 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NUP85.

Description E-value Query
Range
Subject
Range
NUP85_YEAST - Nucleoporin NUP85 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NUP85 PE=1 SV=1
NUP85 - Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC), required for assembly of the sub...
0.0 [1..744] [1..744]
NUP85_SCHPO - Nucleoporin nup85 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=nup85 PE=1 SV=1
nup85 - nucleoporin Nup85
0.0 [69..696] [36..643]
gi|50556854, gi|... - gi|50556854|ref|XP_505835.1| YALI0F24563p [Yarrowia lipolytica], gi|49651705|emb|CAG78646.1| YALI0F2...
gi|18076820, gi|... - gi|49651705|emb|CAG78646.1| YALI0F24563p [Yarrowia lipolytica], gi|18076820|emb|CAC86054.1| Nup85 pr...
0.0 [175..700] [163..647]
gi|17944889 - gi|17944889|gb|AAL48509.1| LD29726p [Drosophila melanogaster]
0.0 [137..691] [100..605]
npp-2 - status:Confirmed UniProt:Q22078 protein_id:CAB00054.1
0.0 [99..697] [3..559]
NUP85_ARATH - Nuclear pore complex protein NUP85 OS=Arabidopsis thaliana GN=NUP85 PE=1 SV=1
0.0 [180..674] [166..655]
gi|51036629, gi|... - gi|51036629|ref|NP_001002929.2| pericentrin 1 [Mus musculus], gi|12856972|dbj|BAB30848.1| unnamed pr...
0.0 [139..696] [100..605]
NUP85 - nucleoporin 85kDa
0.0 [135..696] [96..605]

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Predicted Domain #1
Region A:
Residues: [1-134]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTIDDSNRLL MDVDQFDFLD DGTAQLSNNK TDEEEQLYKR DPVSGAILVP MTVNDQPIEK  60
   61 NGDKMPLKFK LGPLSYQNMA FITAKDKYKL YPVRIPRLDT SKEFSAYVSG LFEIYRDLGD 120
  121 DRVFNVPTIG VVNS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.562 d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.586 b.1.10 Clathrin adaptor appendage domain
View Download 0.628 c.23.12 Formate/glycerate dehydrogenase catalytic domain-like
View Download 0.628 c.23.12 Formate/glycerate dehydrogenase catalytic domain-like
View Download 0.589 c.23.12 Formate/glycerate dehydrogenase catalytic domain-like
View Download 0.586 b.1.10 Clathrin adaptor appendage domain
View Download 0.563 d.58.47 Hypothetical protein VC0424
View Download 0.563 d.58.47 Hypothetical protein VC0424
View Download 0.562 d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.539 c.23.12 Formate/glycerate dehydrogenase catalytic domain-like
View Download 0.529 b.55.1 PH domain-like
View Download 0.511 d.198.1 Type III secretory system chaperone
View Download 0.451 a.4.5 "Winged helix" DNA-binding domain
View Download 0.448 d.130.1 S-adenosylmethionine synthetase
View Download 0.441 b.60.1 Lipocalins
View Download 0.433 a.24.11 Bacterial GAP domain
View Download 0.428 d.109.1 Actin depolymerizing proteins
View Download 0.425 d.109.1 Actin depolymerizing proteins
View Download 0.415 d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.412 d.155.1 Pyruvoyl-dependent histidine and arginine decarboxylases
View Download 0.394 c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.392 c.23.5 Flavoproteins
View Download 0.380 d.110.4 SNARE-like
View Download 0.380 d.58.33 Formylmethanofuran:tetrahydromethanopterin formyltransferase
View Download 0.376 d.233.1 Inhibitor of vertebrate lysozyme, Ivy
View Download 0.363 c.23.1 CheY-like
View Download 0.362 d.109.1 Actin depolymerizing proteins
View Download 0.357 c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.354 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.353 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.330 d.109.1 Actin depolymerizing proteins
View Download 0.323 a.29.2 Bromodomain
View Download 0.319 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.318 d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.317 b.63.1 Oncogene products
View Download 0.304 d.146.1 Uridine diphospho-N-Acetylenolpyruvylglucosamine reductase, MurB, C-terminal domain
View Download 0.304 d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.303 c.47.1 Thioredoxin-like
View Download 0.298 d.65.1 Hedgehog/DD-pepidase
View Download 0.284 a.4.12 TrpR-like
View Download 0.278 d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.272 c.49.1 Pyruvate kinase, C-terminal domain
View Download 0.269 c.97.1 Cytidine deaminase-like
View Download 0.263 b.60.1 Lipocalins
View Download 0.253 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.233 d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.232 a.1.1 Globin-like
View Download 0.225 c.50.1 Macro domain-like
View Download 0.222 c.52.1 Restriction endonuclease-like
View Download 0.218 d.58.12 eEF-1beta-like
View Download 0.216 a.24.15 FAD-dependent thiol oxidase
View Download 0.214 d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.204 d.95.2 Homing endonucleases

Predicted Domain #2
Region A:
Residues: [135-678]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFAKEHNATV NLAMEAILNE LEVFIGRVKD QDGRVNRFYE LEESLTVLNC LRTMYFILDG  60
   61 QDVEENRSEF IESLLNWINR SDGEPDEEYI EQVFSVKDST AGKKVFETQY FWKLLNQLVL 120
  121 RGLLSQAIGC IERSDLLPYL SDTCAVSFDA VSDSIELLKQ YPKDSSSTFR EWKNLVLKLS 180
  181 QAFGSSATDI SGELRDYIED FLLVIGGNQR KILQYSRTWY ESFCGFLLYY IPSLELSAEY 240
  241 LQMSLEANVV DITNDWEQPC VDIISGKIHS ILPVMESLDS CTAAFTAMIC EAKGLIENIF 300
  301 EGEKNSDDYS NEDNEMLEDL FSYRNGMASY MLNSFAFELC SLGDKELWPV AIGLIALSAT 360
  361 GTRSAKKMVI AELLPHYPFV TNDDIEWMLS ICVEWRLPEI AKEIYTTLGN QMLSAHNIIE 420
  421 SIANFSRAGK YELVKSYSWL LFEASCMEGQ KLDDPVLNAI VSKNSPAEDD VIIPQDILDC 480
  481 VVTNSMRQTL APYAVLSQFY ELRDREDWGQ ALRLLLLLIE FPYLPKHYLV LLVAKFLYPI 540
  541 FLLD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [679-744]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKKLMDEDSV ATVIEVIETK WDDADEKSSN LYETIIEADK SLPSSMATLL KNLRKKLNFK  60
   61 LCQAFM

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.747 a.4.5 "Winged helix" DNA-binding domain
View Download 0.746 a.4.1 Homeodomain-like
View Download 0.750 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.725 a.118.11 Cytochrome c oxidase subunit E
View Download 0.707 a.159.2 FF domain
View Download 0.693 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.656 a.65.1 Annexin
View Download 0.631 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.627 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.604 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.586 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.573 a.4.1 Homeodomain-like
View Download 0.556 a.64.1 Saposin
View Download 0.551 a.4.5 "Winged helix" DNA-binding domain
View Download 0.551 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.519 a.4.5 "Winged helix" DNA-binding domain
View Download 0.518 a.118.8 TPR-like
View Download 0.507 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.499 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.498 a.4.1 Homeodomain-like
View Download 0.490 a.4.5 "Winged helix" DNA-binding domain
View Download 0.489 a.4.5 "Winged helix" DNA-binding domain
View Download 0.479 a.46.1 Methionine synthase domain
View Download 0.469 a.153.1 Nuclear receptor coactivator interlocking domain
View Download 0.463 a.17.1 p8-MTCP1
View Download 0.458 a.60.2 RuvA domain 2-like
View Download 0.454 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.453 a.4.1 Homeodomain-like
View Download 0.451 a.51.1 Cytochrome c oxidase subunit h
View Download 0.444 a.64.1 Saposin
View Download 0.440 a.39.1 EF-hand
View Download 0.438 a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.434 a.21.1 HMG-box
View Download 0.428 a.85.1 Hemocyanin, N-terminal domain
View Download 0.416 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.397 a.4.1 Homeodomain-like
View Download 0.396 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.378 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.369 a.64.1 Saposin
View Download 0.360 a.140.2 SAP domain
View Download 0.356 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.351 a.4.8 Ribosomal protein S18
View Download 0.337 a.77.1 DEATH domain
View Download 0.336 a.150.1 Anti-sigma factor AsiA
View Download 0.331 a.4.1 Homeodomain-like
View Download 0.326 a.4.5 "Winged helix" DNA-binding domain
View Download 0.318 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.315 a.4.1 Homeodomain-like
View Download 0.313 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.313 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.308 a.16.1 S15/NS1 RNA-binding domain
View Download 0.307 a.4.1 Homeodomain-like
View Download 0.306 a.157.1 Skp1 dimerisation domain-like
View Download 0.298 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.296 a.23.4 Mitochondrial import receptor subunit Tom20
View Download 0.293 a.4.5 "Winged helix" DNA-binding domain
View Download 0.292 a.61.1 Retroviral matrix proteins
View Download 0.291 a.61.1 Retroviral matrix proteins
View Download 0.291 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.290 a.24.17 Group V grass pollen allergen
View Download 0.287 a.7.7 BAG domain
View Download 0.287 a.144.2 Ribosomal protein L20
View Download 0.286 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.286 a.60.1 SAM/Pointed domain
View Download 0.285 a.23.5 Hemolysin expression modulating protein HHA
View Download 0.284 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.275 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.273 a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.268 d.54.1 Enolase N-terminal domain-like
View Download 0.267 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.267 d.50.3 PI-Pfui intein middle domain
View Download 0.262 a.28.1 ACP-like
View Download 0.258 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.254 a.118.1 ARM repeat
View Download 0.251 a.47.2 t-snare proteins
View Download 0.248 a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.247 a.28.3 Retrovirus capsid protein C-terminal domain
View Download 0.244 a.118.9 ENTH/VHS domain
View Download 0.241 c.102.1 Cell-division inhibitor MinC, N-terminal domain
View Download 0.239 f.15.1 Small-conductance potassium channel
View Download 0.237 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.235 a.4.5 "Winged helix" DNA-binding domain
View Download 0.229 a.164.1 C-terminal domain of DFF45/ICAD (DFF-C domain)
View Download 0.229 a.8.3 Families 57/38 glycoside transferase middle domain
View Download 0.227 d.57.1 DNA damage-inducible protein DinI
View Download 0.223 a.161.1 beta-catenin-interacting protein ICAT
View Download 0.221 a.4.5 "Winged helix" DNA-binding domain
View Download 0.219 d.58.11 EF-G/eEF-2 domains III and V
View Download 0.218 a.70.1 N-terminal domain of the delta subunit of the F1F0-ATP synthase
View Download 0.209 d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.209 d.39.1 Dynein light chain 8 (DLC8)
View Download 0.209 d.45.1 ClpS-like
View Download 0.202 a.2.3 Chaperone J-domain
View Download 0.200 a.60.9 lambda integrase-like, N-terminal domain


YRC Informatics Platform - Version 3.0
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