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View Structure Prediction Details

Protein: TMA22
Organism: Saccharomyces cerevisiae
Length: 198 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TMA22.

Description E-value Query
Range
Subject
Range
TMA22 - Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; intera...
DENR_YEAST - Translation machinery-associated protein 22 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)...
gi|207343896 - gi|207343896|gb|EDZ71214.1| YJR014Wp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190409501 - gi|190409501|gb|EDV12766.1| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]
DENR_YEAS7 - Translation machinery-associated protein 22 OS=Saccharomyces cerevisiae (strain YJM789) GN=TMA22 PE=...
4.0E-51 [1..184] [1..184]
gi|30793919, gi|... - gi|62319631|dbj|BAD95123.1| hypothetical protein [Arabidopsis thaliana], gi|51971214|dbj|BAD44299.1|...
9.0E-48 [4..186] [9..194]
gi|4755083 - gi|4755083|gb|AAC02985.2| density regulated protein drp1 [Homo sapiens]
2.0E-47 [5..188] [76..243]
DENR_SCHPO - Translation machinery-associated protein 22 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) G...
SPBC16C6.05 - translation initiation factor
1.0E-44 [2..190] [9..189]
DENR_MOUSE - Density-regulated protein OS=Mus musculus GN=Denr PE=1 SV=1
1.0E-43 [5..188] [31..198]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
3.0E-43 [3..183] [7..178]
gi|12831046, gi|... - gi|13095857|ref|NP_076747.1| Orf52 [Lactococcus phage bIL309], gi|12831046|gb|AAK08400.1|AF323670_52...
gi|15672462, gi|... - gi|15672462|ref|NP_266636.1| prophage pi1 protein 45 [Lactococcus lactis subsp. lactis Il1403], gi|1...
gi|25401036 - pir||H86684 prophage pi1 protein 45, tail component [imported] - Lactococcus lactis subsp. lactis (s...
7.0E-31 [19..156] [325..465]

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Predicted Domain #1
Region A:
Residues: [1-62]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLREVIYCGI CSYPPEYCEF SGKLKRCKVW LSENHADLYA KLYGTDDNTQ EVEAVTNKLA  60
   61 ES

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.506 a.3.1 Cytochrome c
View Download 0.524 a.77.1 DEATH domain
View Download 0.459 a.4.1 Homeodomain-like
View Download 0.430 d.74.2 C-terminal domain of arginine repressor
View Download 0.434 a.60.11 Hypothetical protein YjbJ
View Download 0.426 d.120.1 Cytochrome b5
View Download 0.402 a.60.1 SAM/Pointed domain
View Download 0.389 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.371 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.369 d.58.1 4Fe-4S ferredoxins
View Download 0.353 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.337 a.3.1 Cytochrome c
View Download 0.282 d.120.1 Cytochrome b5
View Download 0.280 a.77.1 DEATH domain
View Download 0.256 a.64.1 Saposin
View Download 0.240 a.156.1 S13-like H2TH domain
View Download 0.236 a.39.1 EF-hand
View Download 0.220 a.60.1 SAM/Pointed domain
View Download 0.219 a.4.1 Homeodomain-like
View Download 0.219 a.64.2 Bacteriocin AS-48
View Download 0.201 a.139.1 Type I dockerin domain

Predicted functions:

Term Confidence Notes
binding 1.36535619829821 bayes_pls_golite062009
translation initiation factor activity 0.221356879029422 bayes_pls_golite062009
nucleic acid binding 0.213614307171087 bayes_pls_golite062009
protein binding 0.189517592830504 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [63-198]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SIGEAREEKL EKDLLKIQKK QENREQRELA KKLSSKVIIK REARTKRKFI VAISGLEVFD  60
   61 IDMKKLAKTF ASRFATGCSV SKNAEKKEEV VIQGDVMDEV ETYIHSLLEE KGLKDVKVET 120
  121 IDAKKKKKPA AEGAAK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.221849
Match: 1d1rA_
Description: YciH
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle