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View Structure Prediction Details

Protein: SET2
Organism: Saccharomyces cerevisiae
Length: 733 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SET2.

Description E-value Query
Range
Subject
Range
SET2 - Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of ...
0.0 [1..724] [1..724]
set2 - histone lysine methyltransferase Set2
SET2_SCHPO - Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Schizosaccharomyces pombe (strain 972 /...
0.0 [21..706] [82..774]
gi|50512435, gi|... - gi|50512435|gb|AAT77612.1| HSPC069 isoform a [Homo sapiens], gi|12697196|emb|CAC28349.1| huntingtin ...
3.0E-92 [39..439] [965..1333]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
3.0E-68 [4..336] [916..1268]
gi|13442965 - gi|13442965|gb|AAK26242.1|AF247132_1 putative chromatin remodeling factor [Mus musculus]
5.0E-66 [31..325] [1762..2057]

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Predicted Domain #1
Region A:
Residues: [1-89]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKNQSVSAS EDEKEILNNN AEGHKPQRLF DQEPDLTEEA LTKFENLDDC IYANKRIGTF  60
   61 KNNDFMECDC YEEFSDGVNH ACDEDSDCI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [90-279]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NRLTLIECVN DLCSSCGNDC QNQRFQKKQY APIAIFKTKH KGYGVRAEQD IEANQFIYEY  60
   61 KGEVIEEMEF RDRLIDYDQR HFKHFYFMML QNGEFIDATI KGSLARFCNH SCSPNAYVNK 120
  121 WVVKDKLRMG IFAQRKILKG EEITFDYNVD RYGAQAQKCY CEEPNCIGFL GGKTQTDAAS 180
  181 LLPQNIADAL 

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 64.031517
Match: PF00856
Description: SET domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [280-733]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVTVSMEKKW LKLKKLSGEP IIKNENENIN IEFLQSLEVQ PIDSPVDVTK IMSVLLQQDN  60
   61 KIIASKLLKR LFTIDDDSLR HQAIKLHGYT CFSKMLKLFI TEQPQVDGKG NETEEDDIKF 120
  121 IKGILDFLLE LPKTTRNGIE SSQIDNVVKT LPAKFPFLKP NCDELLEKWS KFETYKRITK 180
  181 KDINVAASKM IDLRRVRLPP GWEIIHENGR PLYYNAEQKT KLHYPPSGSS KVFSSRSNTQ 240
  241 VNSPSSSGIP KTPGALDSKK HKLSDEEYER KKQKRLEYER IALERAKQEE LESLKQKLKL 300
  301 ENERKSVLED IIAEFNKQKE LQKEESKKLV EAKEAKRLKR KTVSQSQRLE HNWNKFFASF 360
  361 VPNLIKKNPQ SKQFDHENIK QCAKDIVKIL TTKELKKDSS RAPPDDLTKG KRHKVKEFIN 420
  421 SYMDKIILKK KQKKALGLSS ASTRMSSPPP STSS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [608-733]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LVEAKEAKRL KRKTVSQSQR LEHNWNKFFA SFVPNLIKKN PQSKQFDHEN IKQCAKDIVK  60
   61 ILTTKELKKD SSRAPPDDLT KGKRHKVKEF INSYMDKIIL KKKQKKALGL SSASTRMSSP 120
  121 PPSTSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.30103
Match: 2c5zA
Description: Structure and CTD binding of the Set2 SRI domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle