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View Structure Prediction Details

Protein: SET2
Organism: Saccharomyces cerevisiae
Length: 733 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SET2.

Description E-value Query
Range
Subject
Range
SET2 - Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of ...
0.0 [1..724] [1..724]
set2 - histone lysine methyltransferase Set2
SET2_SCHPO - Histone-lysine N-methyltransferase, H3 lysine-36 specific OS=Schizosaccharomyces pombe (strain 972 /...
0.0 [21..706] [82..774]
gi|50512435, gi|... - gi|50512435|gb|AAT77612.1| HSPC069 isoform a [Homo sapiens], gi|12697196|emb|CAC28349.1| huntingtin ...
3.0E-92 [39..439] [965..1333]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
3.0E-68 [4..336] [916..1268]
gi|13442965 - gi|13442965|gb|AAK26242.1|AF247132_1 putative chromatin remodeling factor [Mus musculus]
5.0E-66 [31..325] [1762..2057]

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Predicted Domain #1
Region A:
Residues: [1-89]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKNQSVSAS EDEKEILNNN AEGHKPQRLF DQEPDLTEEA LTKFENLDDC IYANKRIGTF  60
   61 KNNDFMECDC YEEFSDGVNH ACDEDSDCI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.475 d.42.1 POZ domain
View Download 0.465 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.456 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.575 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.484 a.12.1 Kix domain of CBP (creb binding protein)
View Download 0.455 a.64.1 Saposin
View Download 0.453 a.46.1 Methionine synthase domain
View Download 0.401 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.395 d.150.1 4'-phosphopantetheinyl transferase
View Download 0.387 a.118.1 ARM repeat
View Download 0.377 a.5.6 Hypothetical protein MTH1615
View Download 0.362 a.2.11 Fe,Mn superoxide dismutase (SOD), N-terminal domain
View Download 0.354 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.352 a.74.1 Cyclin-like
View Download 0.348 a.64.1 Saposin
View Download 0.344 a.2.3 Chaperone J-domain
View Download 0.341 a.4.1 Homeodomain-like
View Download 0.339 a.29.4 RecG, N-terminal domain
View Download 0.332 a.126.1 Serum albumin-like
View Download 0.313 a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.293 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.286 a.24.17 Group V grass pollen allergen
View Download 0.285 d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.282 a.74.1 Cyclin-like
View Download 0.275 d.203.1 DsrC, the gamma subunit of dissimilatory sulfite reductase
View Download 0.271 f.17.1 F1F0 ATP synthase subunit C
View Download 0.254 d.42.1 POZ domain
View Download 0.253 a.64.1 Saposin
View Download 0.246 a.112.1 Description not found.
View Download 0.244 a.4.5 "Winged helix" DNA-binding domain
View Download 0.244 f.28.1 Nonheme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
View Download 0.238 a.7.1 Spectrin repeat
View Download 0.233 a.24.3 Cytochromes
View Download 0.227 a.26.1 4-helical cytokines
View Download 0.225 a.4.12 TrpR-like
View Download 0.216 c.78.2 Aspartate/glutamate racemase
View Download 0.215 f.28.1 Nonheme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
View Download 0.210 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.206 a.142.1 PTS-regulatory domain, PRD

Predicted Domain #2
Region A:
Residues: [90-279]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NRLTLIECVN DLCSSCGNDC QNQRFQKKQY APIAIFKTKH KGYGVRAEQD IEANQFIYEY  60
   61 KGEVIEEMEF RDRLIDYDQR HFKHFYFMML QNGEFIDATI KGSLARFCNH SCSPNAYVNK 120
  121 WVVKDKLRMG IFAQRKILKG EEITFDYNVD RYGAQAQKCY CEEPNCIGFL GGKTQTDAAS 180
  181 LLPQNIADAL 

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 64.031517
Match: PF00856
Description: SET domain

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [280-733]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVTVSMEKKW LKLKKLSGEP IIKNENENIN IEFLQSLEVQ PIDSPVDVTK IMSVLLQQDN  60
   61 KIIASKLLKR LFTIDDDSLR HQAIKLHGYT CFSKMLKLFI TEQPQVDGKG NETEEDDIKF 120
  121 IKGILDFLLE LPKTTRNGIE SSQIDNVVKT LPAKFPFLKP NCDELLEKWS KFETYKRITK 180
  181 KDINVAASKM IDLRRVRLPP GWEIIHENGR PLYYNAEQKT KLHYPPSGSS KVFSSRSNTQ 240
  241 VNSPSSSGIP KTPGALDSKK HKLSDEEYER KKQKRLEYER IALERAKQEE LESLKQKLKL 300
  301 ENERKSVLED IIAEFNKQKE LQKEESKKLV EAKEAKRLKR KTVSQSQRLE HNWNKFFASF 360
  361 VPNLIKKNPQ SKQFDHENIK QCAKDIVKIL TTKELKKDSS RAPPDDLTKG KRHKVKEFIN 420
  421 SYMDKIILKK KQKKALGLSS ASTRMSSPPP STSS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.427 d.188.1 Prokaryotic ribosomal protein L17
View Download 0.424 d.54.1 Enolase N-terminal domain-like
View Download 0.382 a.1.1 Globin-like
View Download 0.378 a.74.1 Cyclin-like
View Download 0.344 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain

Predicted Domain #4
Region A:
Residues: [608-733]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LVEAKEAKRL KRKTVSQSQR LEHNWNKFFA SFVPNLIKKN PQSKQFDHEN IKQCAKDIVK  60
   61 ILTTKELKKD SSRAPPDDLT KGKRHKVKEF INSYMDKIIL KKKQKKALGL SSASTRMSSP 120
  121 PPSTSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 36.30103
Match: 2c5zA
Description: Structure and CTD binding of the Set2 SRI domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle