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View Structure Prediction Details

Protein: ZAP1
Organism: Saccharomyces cerevisiae
Length: 880 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ZAP1.

Description E-value Query
Range
Subject
Range
ZNF91 - zinc finger protein 91
0.0 [7..879] [283..1134]
ZO71_XENLA - Oocyte zinc finger protein XlCOF7.1 (Fragment) OS=Xenopus laevis PE=2 SV=1
0.0 [231..850] [265..876]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [6..879] [96..1016]

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Predicted Domain #1
Region A:
Residues: [1-118]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDALTPRDSP KRDDSMATSA ATAASAKPDA LTIGKEGIVH GHIHNYNNLT YIHGHLHHSA  60
   61 PVNDSSASAT PAAAAVADAA TSAFASGASH DMGGDCHVNE KCKEYTDCQH FEFLNYHN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [119-286]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPSLTKYNDT ATYNSNNHSF ANNFHSVASD PTSPQQNSKS DLPRRKDSWF NDDLILLPSS  60
   61 KKNKPNPPPG SDDCYCTPKI LEICCDETHP KSEANIKQGE SDQPTKKDIS ENGNDVAIFT 120
  121 DVKNDHLMPN FNLHDQYCNS TNHDSHNHNN TVPDSFSQLM SHLSEIDC

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [287-408]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLTCDTPCTA STSATSGHKF VQDHQSSNND DVFHKYCKFC EESTDNQPCS KHMHLESKPP  60
   61 QLPPKCSSLR KPTNTLQGTN HAYHEHILNT DMDLKILEDL CNISSLYEVP FGKHINHHDH 120
  121 NN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [409-559]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AGNGCDGSST GNNENGNQTM NLLLSSINRC NPKNNLNGSN NNTAGATSTD HQHHHHRIQF  60
   61 HSHKPNRNNI VNNSGISAAN TTADLTNNDL NDLISREYSY ERFRNQSEPP SLPKVTHQNQ 120
  121 KNRRSWPTKD LESTDFSSLE DSLPSSISPP I

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.70988788192472 bayes_pls_golite062009
nucleic acid binding 4.58713908116892 bayes_pls_golite062009
DNA binding 4.56219307357342 bayes_pls_golite062009
transcription factor activity 3.50954949535763 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22082323675675 bayes_pls_golite062009
binding 3.10743787485868 bayes_pls_golite062009
transcription activator activity 2.19952417915035 bayes_pls_golite062009
chromatin binding 2.18464662431232 bayes_pls_golite062009
transcription repressor activity 1.64349785387632 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.63161912031789 bayes_pls_golite062009
sequence-specific DNA binding 1.42975942698743 bayes_pls_golite062009
transcription factor binding 1.39608963544799 bayes_pls_golite062009
protein binding 1.00484935878505 bayes_pls_golite062009
transcription cofactor activity 0.77874411480713 bayes_pls_golite062009
cation binding 0.528413183335504 bayes_pls_golite062009
metal ion binding 0.528413183335504 bayes_pls_golite062009
ion binding 0.521964257640017 bayes_pls_golite062009
transition metal ion binding 0.495045338513967 bayes_pls_golite062009
catalytic activity 0.245893663605433 bayes_pls_golite062009
transcription corepressor activity 0.10558148421807 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [560-690]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QTTSTINFNW CFKEEKNNDL KCKWKECPES CSSLFDLQRH LLKDHVSQDF KHPMEPLACN  60
   61 WEDCDFLGDD TCSIVNHINC QHGINFDIQF ANPDSFLPGS ISKEKHHLLH CPNPQTHEVS 120
  121 KADGAPDMTS A

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [691-787]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDVSNIPPIK QPEQVICQWD GCNKSFSSAQ ELNDHLEAVH LTRGKSEYQC LWHDCHRTFP  60
   61 QRQKLIRHLK VHSKYKPYKC KTCKRCFSSE ETLVQHT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 227.68867
Match: 2gliA_
Description: Five-finger GLI1
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [788-880]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RTHSGEKPYK CHICNKKFAI SSSLKIHIRT HTGEKPLQCK ICGKRFNESS NLSKHIKTHQ  60
   61 KKYKCSDCSK SFDDLGKLNS QKVKCALERK PYL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 227.68867
Match: 2gliA_
Description: Five-finger GLI1
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle