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View Structure Prediction Details

Protein: MGA2
Organism: Saccharomyces cerevisiae
Length: 1113 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MGA2.

Description E-value Query
Range
Subject
Range
MGA2 - ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive...
MGA2_YEAST - Protein MGA2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MGA2 PE=1 SV=1
0.0 [1..1113] [1..1113]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [335..1011] [93..792]
gi|25121952, gi|... - gi|25121952|ref|NP_733924.1| ankyrin 3, epithelial isoform a [Mus musculus], gi|18203774|gb|AAH21657...
0.0 [335..1011] [76..775]
gi|3885972 - gi|3885972|gb|AAC78143.1| 270 kDa ankyrin G isoform [Rattus norvegicus]
0.0 [335..1011] [93..800]

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Predicted Domain #1
Region A:
Residues: [1-346]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQQNSEFLTE TPGSDPHISQ LHANSVMESQ LLDDFLLNGS PMYQDDSMAH INIDEGANFQ  60
   61 NFIKTDEGDS PNLLSFEGIG NNTHVNQNVS TPLEEEMESN RALKEEEEDE HENKVFNEKN 120
  121 IGNPAHDEIV FGRKETIQSV YINPLDYLKV NAAQLPLDVE VSGLPQVSRV ENQLKLKVKI 180
  181 TSETPLNQSM LYLPSDSISR EKFYLKKNIE DFSEDFKKNL LYINAFVLCA VSNRTTNVCT 240
  241 KCVKREQRRA ARRKSGIADN LLWCNNINRR LVVFNNKQVF PIMKTFDNVK EFELTTRLVC 300
  301 YCRHHKANNG FVILFTITDW QNRLLGKFTT TPIMITDRKP ANMDTT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [347-524]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KFNNTTTSSR RQLTEEESTT EYYSTDNNQL SKDENMPFQY TYQHNPYDND SQMNNIPLKD  60
   61 KNVPFPYSIS QQTDLLQNNN LSLNLSLPNQ HIPSPTSMSE EGSESFNYHH RDNDNPVRTI 120
  121 SLTNIEQQSQ LNQRKRARNN LENDIGKPLF KHSFSNSISA TNTMNPALHS MQDFSMKN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [525-682]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNNNLPSINR VIPSQGPING GIEVTLLGCN FKDGLSVKFG SNLALSTQCW SETTIVTYLP  60
   61 PAAYAGQVFV SITDTNNENN NDDLPQEIEI NDNKKAIFTY VDDTDRQLIE LALQIVGLKM 120
  121 NGKLEDARNI AKRIVGNDSP DSGTNGNSCS KSTGPSPN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 77.211549
Match: 1k1aA_
Description: bcl-3
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [683-801]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QHSMNLNTSV LYSDEVLIQK VIKSLNINSN ISICDSLGRT LLHLACLKNY SSLVYTLIKK  60
   61 GARVNDIDSF GLTPLHFACI SGDPKIIKML LNCKVNYSLR SHNGLTAREV FIANHIHSK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 77.211549
Match: 1k1aA_
Description: bcl-3
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [802-869]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EIDKKQDNRD NHKFVHNDTY ISEVLSLFEE FQNGTKFTDS VETDSNYSIS RKYSQSSFNS  60
   61 SLLDNESL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.045757
Match: 1lnnA_
Description: No description for 1lnnA_ was found.

Predicted functions:

Term Confidence Notes
protein binding 2.69918165732603 bayes_pls_golite062009
binding 2.17983095277661 bayes_pls_golite062009
transcription regulator activity 1.77275610412175 bayes_pls_golite062009
nucleic acid binding 1.31270638552607 bayes_pls_golite062009
DNA binding 1.1922382945387 bayes_pls_golite062009
transcription activator activity 1.13308454180419 bayes_pls_golite062009
transcription factor activity 0.72431748142192 bayes_pls_golite062009
transcription factor binding 0.56378250255767 bayes_pls_golite062009
sequence-specific DNA binding 0.443598477652456 bayes_pls_golite062009
signal transducer activity 0.177373330518427 bayes_pls_golite062009
molecular transducer activity 0.177373330518427 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.0844768926216624 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [870-980]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NENLFESQSM INPTSMEIQH PTLQLFENSS YSEYDQSDFE EDGDEDLFVT DEVEKPGVAC  60
   61 REEQSELLDI GSSANEPEED NGSTSLWNRV LHRINDDLPK YEDLFPLSWG K

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.214 a.118.1 ARM repeat

Predicted Domain #7
Region A:
Residues: [981-1059]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDKLKTTNQD SIVEQSASNI ENSENSEEED YEEEEEFLKK QFNRFFQNKQ NFRNDKMLIF  60
   61 FWIPLTLLLL TWFIMYKFG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1060-1113]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NQDSSINHIS ELISEYLRIA LAKFLLGNER MKTAFRSKLS NLQTTRMLND LIVS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.502 f.13.1 Family A G protein-coupled receptor-like
View Download 0.502 a.16.1 S15/NS1 RNA-binding domain
View Download 0.511 a.2.7 tRNA-binding arm
View Download 0.475 a.157.1 Skp1 dimerisation domain-like
View Download 0.471 a.30.1 ROP protein
View Download 0.459 a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.453 a.2.9 C-terminal UvrC-binding domain of UvrB
View Download 0.447 a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.446 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.437 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.415 a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.413 a.4.5 "Winged helix" DNA-binding domain
View Download 0.397 a.4.1 Homeodomain-like
View Download 0.355 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.348 d.58.8 Viral DNA-binding domain
View Download 0.328 d.58.3 Protease propeptides/inhibitors
View Download 0.319 a.4.1 Homeodomain-like
View Download 0.308 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.304 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.297 d.58.49 YajQ-like
View Download 0.294 a.140.2 SAP domain
View Download 0.291 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.254 a.4.1 Homeodomain-like
View Download 0.251 a.32.1 Transcription factor IIA (TFIIA), alpha-helical domain
View Download 0.249 a.4.5 "Winged helix" DNA-binding domain
View Download 0.245 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.238 d.58.38 Urease metallochaperone UreE, C-terminal domain
View Download 0.232 f.17.1 F1F0 ATP synthase subunit C
View Download 0.232 f.15.1 Small-conductance potassium channel
View Download 0.225 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.213 d.59.1 Ribosomal protein L30p/L7e
View Download 0.207 a.2.3 Chaperone J-domain
View Download 0.206 g.1.1 Insulin-like
View Download 0.202 a.32.1 Transcription factor IIA (TFIIA), alpha-helical domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle