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View Structure Prediction Details

Protein: TMA108
Organism: Saccharomyces cerevisiae
Length: 946 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TMA108.

Description E-value Query
Range
Subject
Range
ANPEP - alanyl (membrane) aminopeptidase
0.0 [4..943] [72..963]
gi|4100305 - gi|4100305|gb|AAD09272.1| aminopeptidase N [Felis catus]
0.0 [4..943] [70..963]
AMPN_RABIT - Aminopeptidase N OS=Oryctolagus cuniculus GN=ANPEP PE=1 SV=4
0.0 [4..943] [69..962]
gi|627700 - pir||A53984 membrane alanyl aminopeptidase (EC 3.4.11.2) - pig
AMPN_PIG - Aminopeptidase N OS=Sus scrofa GN=ANPEP PE=1 SV=3
0.0 [4..942] [68..959]
AMPN_RAT - Aminopeptidase N OS=Rattus norvegicus GN=Anpep PE=1 SV=2
0.0 [4..943] [72..962]
gi|26252164, gi|... - gi|26252164|gb|AAH40792.1| Anpep protein [Mus musculus], gi|16877511|gb|AAH17011.1| Anpep protein [M...
0.0 [4..943] [80..970]

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Predicted Domain #1
Region A:
Residues: [1-227]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDNLLSLEN PVVPSHYELR LEIDPKQSSP NFKGSAIIHL KFNPNSTTLA SIEDSFTQFK  60
   61 LHSKDLIVLS AHATIGSTKF DLKISQDTGK HLSIFNSESP IQLSNDCPLI LSVQYVGKIR 120
  121 DIKTHHDKTF GIFKTNFMDR KTGTANNHVV ATHCQPFSAS NIFPCIDEPS NKSTFQLNIA 180
  181 TDAQYKAVSN TPVEMVEALD SSQKHLVKFA KTPLMTTSVF GFSIGDL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 169.9691
Match: 1hs6A_
Description: Leukotriene A4 hydrolase C-terminal domain; Leukotriene A4 hydrolase N-terminal domain; Leukotriene A4 hydrolase catalytic domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [228-328]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EFLKTEIKLE GDRTIPVSIY APWDIANAAF TLDTVQKYLP LLESYFKCPY PLPKLDFVLL  60
   61 PYLSDMAMEN FGMITIQLNH LLIPPNALAN ETVREQAQQL I

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 169.9691
Match: 1hs6A_
Description: Leukotriene A4 hydrolase C-terminal domain; Leukotriene A4 hydrolase N-terminal domain; Leukotriene A4 hydrolase catalytic domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [329-522]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VHELVHQWMG NYISFDSWES LWFNESFATW LACHILEQNG DLSHYWTSEP YLLQQVEPTM  60
   61 CRDAADVNGR SIFQIAQRNT GIDSQTSDIF DPEAYTKGII MLRSLQLATG ESHLQKGLES 120
  121 VFEDTKTFHA RSVKPMDIWN HIGKFLKSQN ITNFVSSWTR TPGLPVVKVE VEEKDGKTQT 180
  181 KLTQHRFINQ LSTE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 169.9691
Match: 1hs6A_
Description: Leukotriene A4 hydrolase C-terminal domain; Leukotriene A4 hydrolase N-terminal domain; Leukotriene A4 hydrolase catalytic domain
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [523-581]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EKDQLEDVPY QVPLFGVLPD GKMDTKNVLL TDRTLKFDYP ILVINHLAQG YYRVSYESE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.644 a.60.2 RuvA domain 2-like
View Download 0.641 d.58.3 Protease propeptides/inhibitors
View Download 0.749 d.68.3 SirA-like
View Download 0.661 d.68.7 R3H domain
View Download 0.821 d.58.23 Probable ACP-binding domain of malonyl-CoA ACP transacylase
View Download 0.636 a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.610 d.58.1 4Fe-4S ferredoxins
View Download 0.601 a.60.12 DNA polymerase beta-like, second domain
View Download 0.596 d.58.36 Sulfite reductase, domains 1 and 3
View Download 0.550 d.58.17 Metal-binding domain
View Download 0.550 a.60.1 SAM/Pointed domain
View Download 0.472 a.4.1 Homeodomain-like
View Download 0.460 d.58.7 RNA-binding domain, RBD
View Download 0.458 a.50.1 Anaphylotoxins (complement system)
View Download 0.449 d.15.7 Immunoglobulin-binding domains
View Download 0.444 c.23.1 CheY-like
View Download 0.439 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.438 a.4.1 Homeodomain-like
View Download 0.410 d.58.38 Urease metallochaperone UreE, C-terminal domain
View Download 0.400 d.58.38 Urease metallochaperone UreE, C-terminal domain
View Download 0.382 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.382 a.4.1 Homeodomain-like
View Download 0.355 d.58.24 CheY-binding domain of CheA
View Download 0.335 d.58.17 Metal-binding domain
View Download 0.330 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.326 a.4.13 Sigma3 and sigma4 domains of RNA polymerase sigma factors
View Download 0.302 a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.289 g.7.1 Snake toxin-like
View Download 0.276 d.79.3 L30e-like
View Download 0.264 a.4.5 "Winged helix" DNA-binding domain
View Download 0.257 g.18.1 Complement control module/SCR domain
View Download 0.254 d.58.25 Killer toxin KP6 alpha-subunit
View Download 0.243 d.95.2 Homing endonucleases
View Download 0.231 a.48.3 Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
View Download 0.229 a.4.5 "Winged helix" DNA-binding domain
View Download 0.225 a.139.1 Type I dockerin domain
View Download 0.209 a.4.5 "Winged helix" DNA-binding domain

Predicted Domain #5
Region A:
Residues: [582-839]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ECYALINDKI TEETLSEIDL RKIFLDLSQF IGDEGFQNSI HLHGLFKILN HIASPSTKIA  60
   61 SKYWDPLSKG LEVLQTIDRA SLTSSKLQSF LKKKIVIPLF NKIDWPHGEF DKSTNPHELK 120
  121 VMSQVLFLNK NSAKCAELCQ IYFKHLLQGP RSSVPLELVN SILVVVSQHC ANIKQWKKIF 180
  181 DLVKRSSCTG ITNHVINMYD QNSSETAMLI QNGAIESLGF CLDSDIVKKT LNFITSNIES 240
  241 EGMELALFGF NYNFKKRL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [840-946]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKNEKPQDQV VRETIWEWYM GNFDQWARKA TRKGTTTGDH LHKALRSISL IIFQMFVADE  60
   61 PQKIEKFINL EKEKLGQSLL SLDDIWASVQ QDEESRKTIR RDLASLV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.806 0.044 cytoplasm a.1.1 Globin-like
View Download 0.782 0.044 cytoplasm a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.899 0.044 cytoplasm a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.741 0.044 cytoplasm a.63.1 Apolipophorin-III
View Download 0.740 0.044 cytoplasm a.112.1 Description not found.
View Download 0.700 0.044 cytoplasm a.19.1 Fertilization protein
View Download 0.665 0.044 cytoplasm f.13.1 Family A G protein-coupled receptor-like
View Download 0.656 0.044 cytoplasm a.46.1 Methionine synthase domain
View Download 0.580 0.044 cytoplasm a.47.2 t-snare proteins
View Download 0.576 0.044 cytoplasm a.118.1 ARM repeat
View Download 0.561 0.044 cytoplasm a.1.1 Globin-like
View Download 0.509 0.044 cytoplasm a.47.2 t-snare proteins
View Download 0.505 0.044 cytoplasm a.24.9 alpha-catenin/vinculin
View Download 0.502 0.044 cytoplasm a.25.1 Ferritin-like
View Download 0.498 0.044 cytoplasm a.24.17 Group V grass pollen allergen
View Download 0.497 0.044 cytoplasm a.1.1 Globin-like
View Download 0.488 0.044 cytoplasm a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.471 0.044 cytoplasm a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.465 0.044 cytoplasm f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.454 0.044 cytoplasm a.25.1 Ferritin-like
View Download 0.452 0.044 cytoplasm a.24.9 alpha-catenin/vinculin
View Download 0.443 0.044 cytoplasm a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.442 0.044 cytoplasm a.24.2 Aspartate receptor, ligand-binding domain
View Download 0.439 0.044 cytoplasm a.60.6 DNA polymerase beta, N-terminal domain-like
View Download 0.434 0.044 cytoplasm a.24.3 Cytochromes
View Download 0.429 0.044 cytoplasm a.7.6 Ribosomal protein S20
View Download 0.414 0.044 cytoplasm d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.413 0.044 cytoplasm a.64.1 Saposin
View Download 0.412 0.044 cytoplasm a.4.12 TrpR-like
View Download 0.405 0.044 cytoplasm f.14.1 Voltage-gated potassium channels
View Download 0.393 0.044 cytoplasm a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.379 0.044 cytoplasm a.1.1 Globin-like
View Download 0.376 0.044 cytoplasm a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.367 0.044 cytoplasm a.85.1 Hemocyanin, N-terminal domain
View Download 0.355 0.044 cytoplasm a.133.1 Phospholipase A2, PLA2
View Download 0.351 0.044 cytoplasm a.60.9 lambda integrase-like, N-terminal domain
View Download 0.346 0.044 cytoplasm a.1.1 Globin-like
View Download 0.344 0.044 cytoplasm a.69.1 C-terminal domain of alpha and beta subunits of F1 ATP synthase
View Download 0.339 0.044 cytoplasm a.118.8 TPR-like
View Download 0.337 0.044 cytoplasm a.59.1 PAH2 domain
View Download 0.333 0.044 cytoplasm a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.319 0.044 cytoplasm a.4.12 TrpR-like
View Download 0.318 0.044 cytoplasm a.118.11 Cytochrome c oxidase subunit E
View Download 0.315 0.044 cytoplasm a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.308 0.044 cytoplasm a.24.3 Cytochromes
View Download 0.304 0.044 cytoplasm c.23.12 Formate/glycerate dehydrogenase catalytic domain-like
View Download 0.301 0.044 cytoplasm a.69.2 Ypt/Rab-GAP domain of gyp1p
View Download 0.300 0.044 cytoplasm a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.298 0.044 cytoplasm a.24.9 alpha-catenin/vinculin
View Download 0.296 0.044 cytoplasm a.71.2 Helical domain of Sec23/24
View Download 0.294 0.044 cytoplasm a.24.4 Hemerythrin
View Download 0.289 0.044 cytoplasm a.26.1 4-helical cytokines
View Download 0.288 0.044 cytoplasm a.11.2 Second domain of FERM
View Download 0.287 0.044 cytoplasm a.126.1 Serum albumin-like
View Download 0.280 0.044 cytoplasm d.216.1 Rotavirus NSP2 fragment, N-terminal domain
View Download 0.279 0.044 cytoplasm d.150.1 4'-phosphopantetheinyl transferase
View Download 0.278 0.044 cytoplasm a.5.4 Elongation factor TFIIS domain 2
View Download 0.273 0.044 cytoplasm d.203.1 DsrC, the gamma subunit of dissimilatory sulfite reductase
View Download 0.269 0.044 cytoplasm a.8.2 Plasmid maintenance system epsilon/zeta, antidote epsilon subunit
View Download 0.265 0.044 cytoplasm a.62.1 Hepatitis B viral capsid (hbcag)
View Download 0.263 0.044 cytoplasm a.4.1 Homeodomain-like
View Download 0.255 0.044 cytoplasm d.188.1 Prokaryotic ribosomal protein L17
View Download 0.254 0.044 cytoplasm a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.253 0.044 cytoplasm d.96.1 Tetrahydrobiopterin biosynthesis enzymes-like
View Download 0.251 0.044 cytoplasm a.118.14 FliG
View Download 0.251 0.044 cytoplasm a.74.1 Cyclin-like
View Download 0.249 0.044 cytoplasm a.118.1 ARM repeat
View Download 0.249 0.044 cytoplasm a.22.1 Histone-fold
View Download 0.249 0.044 cytoplasm c.55.7 Methylated DNA-protein cysteine methyltransferase domain
View Download 0.247 0.044 cytoplasm d.150.1 4'-phosphopantetheinyl transferase
View Download 0.246 0.044 cytoplasm f.14.1 Voltage-gated potassium channels
View Download 0.246 0.044 cytoplasm a.60.10 Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
View Download 0.245 0.044 cytoplasm a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.244 0.044 cytoplasm a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.243 0.044 cytoplasm a.65.1 Annexin
View Download 0.243 0.044 cytoplasm a.61.1 Retroviral matrix proteins
View Download 0.240 0.044 cytoplasm f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.239 0.044 cytoplasm a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.234 0.044 cytoplasm a.4.5 "Winged helix" DNA-binding domain
View Download 0.233 0.044 cytoplasm a.1.1 Globin-like
View Download 0.232 0.044 cytoplasm f.15.1 Small-conductance potassium channel
View Download 0.229 0.044 cytoplasm a.72.1 Functional domain of the splicing factor Prp18
View Download 0.229 0.044 cytoplasm a.7.1 Spectrin repeat
View Download 0.227 0.044 cytoplasm a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.226 0.044 cytoplasm a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.225 0.044 cytoplasm a.7.7 BAG domain
View Download 0.220 0.044 cytoplasm a.4.1 Homeodomain-like
View Download 0.216 0.044 cytoplasm d.79.1 YjgF-like
View Download 0.209 0.044 cytoplasm a.71.2 Helical domain of Sec23/24
View Download 0.207 0.044 cytoplasm c.47.1 Thioredoxin-like
View Download 0.207 0.044 cytoplasm a.182.1 GatB/YqeY domain
View Download 0.204 0.044 cytoplasm a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.203 0.044 cytoplasm a.165.1 Myosin phosphatase inhibitor 17kDa protein, CPI-17
View Download 0.201 0.044 cytoplasm a.24.10 Histidine-containing phosphotransfer domain, HPT domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle