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View Structure Prediction Details

Protein: MNI1
Organism: Saccharomyces cerevisiae
Length: 377 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MNI1.

Description E-value Query
Range
Subject
Range
MNI1 - Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; deletion ...
gi|190406321 - gi|190406321|gb|EDV09588.1| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]
gi|207344383 - gi|207344383|gb|EDZ71545.1| YIL110Wp-like protein [Saccharomyces cerevisiae AWRI1631]
HPM1_YEAST - Histidine protein methyltransferase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HP...
0.0 [1..377] [1..377]
gi|12850313 - gi|12850313|dbj|BAB28672.1| unnamed protein product [Mus musculus]
9.0E-76 [93..368] [108..354]
HPM1_SCHPO - Histidine protein methyltransferase 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC...
SPAC1071.05 - S-adenosylmethionine-dependent methyltransferase
2.0E-71 [86..346] [61..296]
C1orf156 - chromosome 1 open reading frame 156
8.0E-71 [93..368] [118..364]
gi|16226903 - gi|16226903|gb|AAL16294.1|AF428364_1 At2g43320/T1O24.6 [Arabidopsis thaliana]
2.0E-60 [110..350] [67..331]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
3.0E-51 [110..346] [67..248]
gi|17945860 - gi|17945860|gb|AAL48976.1| RE38979p [Drosophila melanogaster]
1.0E-35 [92..220] [75..197]

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Predicted Domain #1
Region A:
Residues: [1-120]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFSFGFTSN DFDDDELVAQ PETFVESSKE NENTTAYINP LDSDFLSQAG VVQPNVEDLG  60
   61 TILESLKDVR LTFEEFQSPI YRKPLIKREL FDVKHQLMLE TDAQSNNNST ELDILLGDTS 120
  121 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.811 0.087 S-adenosylmethionine-dependent methyltransferase activity a.133.1 Phospholipase A2, PLA2
View Download 0.216 0.087 S-adenosylmethionine-dependent methyltransferase activity f.32.1 a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
View Download 0.305 0.087 S-adenosylmethionine-dependent methyltransferase activity a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.247 0.087 S-adenosylmethionine-dependent methyltransferase activity a.24.4 Hemerythrin
View Download 0.269 0.087 S-adenosylmethionine-dependent methyltransferase activity a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.201 0.087 S-adenosylmethionine-dependent methyltransferase activity a.24.3 Cytochromes

Predicted functions:

Term Confidence Notes
binding 0.525304726030675 bayes_pls_golite062009
catalytic activity 0.403277401956396 bayes_pls_golite062009
transferase activity 0.318650776741261 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [121-232]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDLRKNIYEG GLKSWECSYD LVDLLSENVD RISNDIDAVV EIGCGTALPS EFLFRSALLR  60
   61 NDRSKGLKFV LTDYNASVLR LVTIPNLVIT WAKTVLTKEQ WYALQKDECE DI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2.221849
Match: 1f3lA_
Description: Arginine methyltransferase, HMT1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [233-377]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PINNEELLLT SKLLAAFYDD VQSRNISVTL ISGSWGRKFS NLIHEVLSGS QKVLSLSSET  60
   61 IYQPDNLPVI AETILDIHNL PQTDVKTYVA AKDIYFGVGG SITEFEAYLD DKINSEHLPI 120
  121 HSERFKVNSG LKRSIICIET NKAIR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.799 c.26.2 Adenine nucleotide alpha hydrolases-like
View Download 0.767 c.23.6 Cobalamin (vitamin B12)-binding domain
View Download 0.661 c.1.11 Enolase C-terminal domain-like
View Download 0.673 c.115.1 Hypothetical protein MTH777 (MT0777)
View Download 0.644 c.49.1 Pyruvate kinase, C-terminal domain
View Download 0.638 c.61.1 PRTase-like
View Download 0.582 d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.555 c.26.1 Nucleotidylyl transferase
View Download 0.542 c.23.5 Flavoproteins
View Download 0.539 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.527 c.84.1 Phosphoglucomutase, first 3 domains
View Download 0.524 c.78.1 Aspartate/ornithine carbamoyltransferase
View Download 0.519 c.1.10 Aldolase
View Download 0.501 c.23.1 CheY-like
View Download 0.488 c.26.2 Adenine nucleotide alpha hydrolases-like
View Download 0.487 c.95.1 Thiolase-like
View Download 0.481 d.169.1 C-type lectin-like
View Download 0.469 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.440 c.59.1 MurD-like peptide ligases, peptide-binding domain
View Download 0.440 c.45.1 (Phosphotyrosine protein) phosphatases II
View Download 0.423 c.25.1 Ferredoxin reductase-like, C-terminal NADP-linked domain
View Download 0.422 c.8.5 GroEL apical domain-like
View Download 0.417 c.8.4 Transferrin receptor ectodomain, apical domain
View Download 0.416 c.36.1 Thiamin diphosphate-binding fold (THDP-binding)
View Download 0.416 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.413 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.412 c.1.1 Triosephosphate isomerase (TIM)
View Download 0.411 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.407 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.401 c.65.1 Formyltransferase
View Download 0.396 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.396 c.61.1 PRTase-like
View Download 0.395 d.118.1 N-acetylmuramoyl-L-alanine amidase-like
View Download 0.393 c.10.1 RNI-like
View Download 0.383 c.3.1 FAD/NAD(P)-binding domain
View Download 0.382 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.380 c.1.11 Enolase C-terminal domain-like
View Download 0.380 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.372 c.116.1 alpha/beta knot
View Download 0.367 c.40.1 Methylesterase CheB, C-terminal domain
View Download 0.364 d.110.4 SNARE-like
View Download 0.360 c.25.1 Ferredoxin reductase-like, C-terminal NADP-linked domain
View Download 0.360 c.25.1 Ferredoxin reductase-like, C-terminal NADP-linked domain
View Download 0.359 c.95.1 Thiolase-like
View Download 0.354 d.58.33 Formylmethanofuran:tetrahydromethanopterin formyltransferase
View Download 0.350 c.55.4 Translational machinery components
View Download 0.348 c.59.1 MurD-like peptide ligases, peptide-binding domain
View Download 0.346 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.345 c.52.3 Eukaryotic RPB5 N-terminal domain
View Download 0.341 c.3.1 FAD/NAD(P)-binding domain
View Download 0.341 d.104.1 Class II aaRS and biotin synthetases
View Download 0.339 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.336 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.332 c.48.1 TK C-terminal domain-like
View Download 0.326 c.108.1 HAD-like
View Download 0.325 c.25.1 Ferredoxin reductase-like, C-terminal NADP-linked domain
View Download 0.321 c.25.1 Ferredoxin reductase-like, C-terminal NADP-linked domain
View Download 0.310 c.1.17 Quinolinic acid phosphoribosyltransferase (Nicotinate-nucleotide pyrophosphorylase, NadC), C-terminal domain
View Download 0.305 c.31.1 DHS-like NAD/FAD-binding domain
View Download 0.291 c.26.1 Nucleotidylyl transferase
View Download 0.290 c.47.1 Thioredoxin-like
View Download 0.285 d.109.1 Actin depolymerizing proteins
View Download 0.284 d.140.1 Ribosomal protein S8
View Download 0.283 d.111.1 PR-1-like
View Download 0.280 c.66.1 S-adenosyl-L-methionine-dependent methyltransferases
View Download 0.280 b.97.1 Anemone pore-forming cytolysin
View Download 0.276 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.266 c.8.6 Swiveling domain of the glycerol dehydratase reactivase alpha subunit
View Download 0.265 c.30.1 PreATP-grasp domain
View Download 0.265 c.51.3 B12-dependend dehydatases associated subunit
View Download 0.262 c.69.1 alpha/beta-Hydrolases
View Download 0.261 c.47.1 Thioredoxin-like
View Download 0.258 c.68.1 Nucleotide-diphospho-sugar transferases
View Download 0.258 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.247 d.110.2 GAF domain-like
View Download 0.242 c.8.1 Phosphohistidine domain
View Download 0.230 c.95.1 Thiolase-like
View Download 0.229 c.52.2 tRNA splicing endonuclease, C-terminal domain
View Download 0.226 c.26.2 Adenine nucleotide alpha hydrolases-like
View Download 0.220 c.16.1 Lumazine synthase
View Download 0.216 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.214 c.45.1 (Phosphotyrosine protein) phosphatases II
View Download 0.208 c.1.2 Ribulose-phoshate binding barrel
View Download 0.207 c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.204 c.1.12 Phosphoenolpyruvate/pyruvate domain
View Download 0.203 c.26.2 Adenine nucleotide alpha hydrolases-like
View Download 0.201 c.52.1 Restriction endonuclease-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle