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View Structure Prediction Details

Protein: GVP36
Organism: Saccharomyces cerevisiae
Length: 326 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GVP36.

Description E-value Query
Range		 Subject
Range
gi|151943118 - gi|151943118|gb|EDN61453.1| Golgi vesicle protein [Saccharomyces cerevisiae YJM789]
GVP36 - BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for ada...
gi|207344298 - gi|207344298|gb|EDZ71488.1| YIL041Wp-like protein [Saccharomyces cerevisiae AWRI1631]
GVP36_YEAST - Protein GVP36 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GVP36 PE=1 SV=1
gi|190406261 - gi|190406261|gb|EDV09528.1| peripheral membrane protein [Saccharomyces cerevisiae RM11-1a]
 3.0E-72 [1..326] [1..326]
gi|60822960, gi|... - gi|60822960|gb|AAX36627.1| SH3-domain GRB2-like 1 [synthetic construct], gi|123980710|gb|ABM82184.1|...
SH3GL1 - SH3-domain GRB2-like 1
 1.0E-65 [32..317] [10..260]
SH3G1_MOUSE - Endophilin-A2 OS=Mus musculus GN=Sh3gl1 PE=1 SV=1
gi|55250502 - gb|AAH86079.1| Unknown (protein for MGC:98448) [Xenopus laevis]
 5.0E-65 [32..317] [10..260]
SH3G1_RAT - Endophilin-A2 OS=Rattus norvegicus GN=Sh3gl1 PE=1 SV=1
 2.0E-64 [32..317] [10..260]
gi|11761988 - gi|11761988|gb|AAG40277.1|AF304353_1 endophilin SH3p4 [Lampetra fluviatilis]
 7.0E-61 [32..322] [10..267]

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Predicted Domain #1
Region A:
Residues: [1-113] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFNAFASSL SKKLQEISTS VSEKTQELPS LAQSTQRMVQ ERLGQVTDIS QLPREYTELE  60
   61 DKVDTIKLIY NHFLGVTAIY ENGSYDYPKY INESVNEFSR SVASKLTELT HAT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 2.2879693624429 bayes_pls_golite062009
protein binding 2.08046860800611 bayes_pls_golite062009
cytoskeletal protein binding 1.02414077739262 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.067852352497379 bayes_pls_golite062009
pyrophosphatase activity 0.0314833132263769 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.0230779033512197 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.0199119414909105 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [114-326] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SASEAQNILV APGPIKEPKT LNYALSKVAL NSSECLNKMF PTEEQPLASA LLQFSDVQAK  60
   61 IAQARIQQDT LIQTKFNKNL RERLSFEIGK ADKCRKDVHS MRLRYDVART NLANNKKPEK 120
  121 EASLRVQMET LEDQFAQVTE DATVCLQEVI SHANFSEDLK ELAKAQAEYF ETSAGLMKEF 180
  181 LSNSFAEEPE AKPEVAEEEK PQTAISMNDE DDA

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.91
Match: 1i49A
Description: Arfaptin, Rac-binding fragment
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle