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View Structure Prediction Details

Protein: DOT5
Organism: Saccharomyces cerevisiae
Length: 215 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DOT5.

Description E-value Query
Range
Subject
Range
PRDX3_BOVIN - Thioredoxin-dependent peroxide reductase, mitochondrial OS=Bos taurus GN=PRDX3 PE=1 SV=2
1.0E-54 [7..213] [10..221]
gi|3328221 - gi|3328221|gb|AAC78473.1| thioredoxin peroxidase [Secale cereale]
9.0E-53 [1..213] [1..223]
gi|11968132, gi|... - gi|4336877|gb|AAD17992.1| PRx III [Rattus norvegicus], gi|11968132|ref|NP_071985.1| peroxiredoxin 3 ...
1.0E-52 [4..213] [2..221]
gi|14250063 - gi|14250063|gb|AAH08435.1| Peroxiredoxin 3 [Homo sapiens]
2.0E-52 [1..213] [1..220]
PRDX3_MOUSE - Thioredoxin-dependent peroxide reductase, mitochondrial OS=Mus musculus GN=Prdx3 PE=1 SV=1
5.0E-51 [1..213] [1..221]

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Predicted Domain #1
Region A:
Residues: [1-215]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGEALRRSTR IAISKRMLEE EESKLAPIST PEVPKKKIKT GPKHNANQAV VQEANRSSDV  60
   61 NELEIGDPIP DLSLLNEDND SISLKKITEN NRVVVFFVYP RASTPGCTRQ ACGFRDNYQE 120
  121 LKKYAAVFGL SADSVTSQKK FQSKQNLPYH LLSDPKREFI GLLGAKKTPL SGSIRSHFIF 180
  181 VDGKLKFKRV KISPEVSVND AKKEVLEVAE KFKEE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 96.28043
Match: 1qq2A_
Description: Thioredoxin peroxidase 2 (thioredoxin peroxidase B, 2-cys peroxiredoxin)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
antioxidant activity 3.66884588063322 bayes_pls_golite062009
peroxidase activity 3.43831566988273 bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor 3.43831566988273 bayes_pls_golite062009
glutathione peroxidase activity 2.56524997297011 bayes_pls_golite062009
peroxiredoxin activity 2.12777217096121 bayes_pls_golite062009
thioredoxin peroxidase activity 1.96134566495756 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors 1.8187537496904 bayes_pls_golite062009
protein disulfide oxidoreductase activity 1.47769936616412 bayes_pls_golite062009
disulfide oxidoreductase activity 1.32811008894503 bayes_pls_golite062009
binding 1.25802922431343 bayes_pls_golite062009
selenium binding 1.1082524159827 bayes_pls_golite062009
catalytic activity 0.672192331361968 bayes_pls_golite062009
transcription regulator activity 0.52671047749426 bayes_pls_golite062009
protein binding 0.134341907247724 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle