YRC Public Data Repository - Protein Structure Prediction

Protein:	PPX1
Organism:	Saccharomyces cerevisiae
Length:	397 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PPX1.

Description	E-value	Query Range	Subject Range
PPX1 - Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cyt... PPX1_YEAST - Exopolyphosphatase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PPX1 PE=1 SV=1	0.0	[1..397]	[1..397]
pn-PA - The gene prune is referred to in FlyBase by the symbol Dmel\pn (CG3461, FBgn0003116). It is a protei... gi\|220945388, gi... - gi\|220955250\|gb\|ACL90168.1\| pn-PA [synthetic construct], gi\|220945388\|gb\|ACL85237.1\| pn-PA [syntheti...	8.0E-65	[1..396]	[7..383]
gi\|6175243 - gi\|6175243\|gb\|AAF04914.1\|U67085_1 TcD37 homolog [Homo sapiens]	1.0E-59	[34..393]	[5..342]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	1.0E-59	[1..396]	[7..382]
PPAC_STRMU - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus mutans serotype c (strain AT... PPAC_STRMU - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus mutans GN=ppaC PE=1 SV=1	2.0E-56	[28..392]	[2..308]
gi\|147925781, gi... - gi\|148988580\|ref\|ZP_01820013.1\| manganese-dependent inorganic pyrophosphatase, putative [Streptococc... gi\|148984882, gi... - gi\|148984882\|ref\|ZP_01818135.1\| manganese-dependent inorganic pyrophosphatase, putative [Streptococc... gi\|168575270, gi... - gi\|183578813\|gb\|EDT99341.1\| manganese-dependent inorganic pyrophosphatase (Pyrophosphate phospho-hyd... gi\|168493435, gi... - gi\|183576254\|gb\|EDT96782.1\| manganese-dependent inorganic pyrophosphatase (Pyrophosphate phospho-hyd... PPAC_STRPS - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pneumoniae (strain CGSP14) G... gi\|147930044, gi... - gi\|149021808\|ref\|ZP_01835815.1\| manganese-dependent inorganic pyrophosphatase, putative [Streptococc... PPAC_STRPI - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pneumoniae (strain Hungary19... gi\|147764203, gi... - gi\|149011772\|ref\|ZP_01832968.1\| manganese-dependent inorganic pyrophosphatase, putative [Streptococc... PPAC_STRPJ - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pneumoniae (strain ATCC 7006... PPAC_STRP2 - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pneumoniae serotype 2 (strai... gi\|149007553, gi... - gi\|149007553\|ref\|ZP_01831188.1\| manganese-dependent inorganic pyrophosphatase, putative [Streptococc... PPAC_STRP4 - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pneumoniae serotype 19F (str... gi\|148997403, gi... - gi\|148997403\|ref\|ZP_01825008.1\| manganese-dependent inorganic pyrophosphatase, putative [Streptococc... gi\|148992576, gi... - gi\|148992576\|ref\|ZP_01822244.1\| manganese-dependent inorganic pyrophosphatase, putative [Streptococc... PPAC_STRPN - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pneumoniae serotype 4 (strai... PPAC_STRPN - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pneumoniae GN=ppaC PE=3 SV=1 PPAC_STRR6 - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pneumoniae (strain ATCC BAA-... PPAC_STRZJ - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pneumoniae (strain JJA) GN=p... PPAC_STRZP - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pneumoniae (strain P1031) GN... PPAC_STRP7 - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pneumoniae (strain 70585) GN... gi\|168487504, gi... - gi\|183569687\|gb\|EDT90215.1\| manganese-dependent inorganic pyrophosphatase (Pyrophosphate phospho-hyd... PPAC_STRZT - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus pneumoniae (strain Taiwan19F... gi\|168484977, gi... - gi\|172041894\|gb\|EDT49940.1\| manganese-dependent inorganic pyrophosphatase (Pyrophosphate phospho-hyd... gi\|242244748, gi... - gi\|242244748\|ref\|ZP_04799185.1\| manganese-dependent inorganic pyrophosphatase [Streptococcus pneumon... gi\|168491574, gi... - gi\|183574197\|gb\|EDT94725.1\| manganese-dependent inorganic pyrophosphatase (Pyrophosphate phospho-hyd... gi\|183572833, gi... - gi\|183572833\|gb\|EDT93361.1\| manganese-dependent inorganic pyrophosphatase (Pyrophosphate phospho-hyd...	2.0E-56	[28..392]	[2..309]
PPX1_SCHPO - Putative exopolyphosphatase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC2F3.11 PE=... SPAC2F3.11 - exopolyphosphatase	6.0E-56	[8..391]	[3..377]
PPAC_STRGC - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus gordonii (strain Challis / A... gi\|1743856 - gi\|1743856\|gb\|AAB39104.1\| intrageneric coaggregation-relevant adhesin [Streptococcus gordonii] PPAC_STRGC - Probable manganese-dependent inorganic pyrophosphatase OS=Streptococcus gordonii (strain Challis / A...	7.0E-56	[28..392]	[2..309]
gi\|16974962, gi\|... - gi\|16974963\|pdb\|1K20\|B Chain B, Inorganic Pyrophosphatase (Family Ii) From Streptococcus Gordonii At...	9.0E-56	[28..392]	[1..308]

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Predicted Domain #1

Region A:
Residues: [1-251]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPLRKTVPE FLAHLKSLPI SKIASNDVLT ICVGNESADM DSIASAITYS YCQYIYNEGT  60
   61 YSEEKKKGSF IVPIIDIPRE DLSLRRDVMY VLEKLKIKEE ELFFIEDLKS LKQNVSQGTE 120
  121 LNSYLVDNND TPKNLKNYID NVVGIIDHHF DLQKHLDAEP RIVKVSGSCS SLVFNYWYEK 180
  181 LQGDREVVMN IAPLLMGAIL IDTSNMRRKV EESDKLAIER CQAVLSGAVN EVSAQGLEDS 240
  241 SEFYKEIKSR K

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	56.522879
Match:	1k20A_
Description:	Manganese-dependent inorganic pyrophosphatase (family II)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nuclease activity	2.22762374984422	bayes_pls_golite062009
hydrolase activity	2.11996205929773	bayes_pls_golite062009
catalytic activity	1.78154379547895	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	1.7679956422453	bayes_pls_golite062009
deoxyribonuclease activity	1.7238398802096	bayes_pls_golite062009
binding	1.52735252886759	bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1.48438369225803	bayes_pls_golite062009
exonuclease activity	1.4791620684568	bayes_pls_golite062009
single-stranded DNA specific exodeoxyribonuclease activity	1.10404503151762	bayes_pls_golite062009
exodeoxyribonuclease activity	0.808006273031307	bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters	0.792120683260194	bayes_pls_golite062009
protein binding	0.332901114484316	bayes_pls_golite062009
inorganic diphosphatase activity	0.158887418739632	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [252-397]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDIKGFSVSD ILKKDYKQFN FQGKGHKGLE IGLSSIVKRM SWLFNEHGGE ADFVNQCRRF  60
   61 QAERGLDVLV LLTSWRKAGD SHRELVILGD SNVVRELIER VSDKLQLQLF GGNLDGGVAM 120
  121 FKQLNVEATR KQVVPYLEEA YSNLEE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	56.522879
Match:	1k20A_
Description:	Manganese-dependent inorganic pyrophosphatase (family II)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: