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View Structure Prediction Details

Protein: RPN10
Organism: Saccharomyces cerevisiae
Length: 268 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RPN10.

Description E-value Query
Range
Subject
Range
gi|8918328 - gi|8918328|dbj|BAA97576.1| pUb-R4 [Mus musculus]
3.0E-91 [1..236] [1..224]
gi|8918353, gi|2... - gi|8918353|dbj|BAA97581.1| pUb-R5 [Homo sapiens], gi|25121958|ref|NP_722544.1| proteasome 26S non-AT...
4.0E-90 [1..236] [1..224]
gi|9957071, gi|3... - gi|9957071|gb|AAG09200.1| 26S proteasome subunit S5a [Rattus norvegicus], gi|38051982|gb|AAH60559.1|...
3.0E-86 [1..236] [1..224]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
3.0E-86 [1..236] [1..224]

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Predicted Domain #1
Region A:
Residues: [1-197]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVLEATVLVI DNSEYSRNGD FPRTRFEAQI DSVEFIFQAK RNSNPENTVG LISGAGANPR  60
   61 VLSTFTAEFG KILAGLHDTQ IEGKLHMATA LQIAQLTLKH RQNKVQHQRI VAFVCSPISD 120
  121 SRDELIRLAK TLKKNNVAVD IINFGEIEQN TELLDEFIAA VNNPQEETSH LLTVTPGPRL 180
  181 LYENIASSPI ILEEGSS

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 15.0
Match: 1dgqA
Description: Integrin CD11a/CD18 (Leukocyte function associated antigen-1, LFA-1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 4.02098822555334 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 3.82496592594463 bayes_pls_golite062009
endopeptidase activity 3.72596563304893 bayes_pls_golite062009
binding 3.32950434867692 bayes_pls_golite062009
hydrolase activity 2.72944528058473 bayes_pls_golite062009
protein binding 1.4332924081006 bayes_pls_golite062009
nucleic acid binding 1.41389987484225 bayes_pls_golite062009
DNA binding 1.27751137443334 bayes_pls_golite062009
protein dimerization activity 0.45109468643752 bayes_pls_golite062009
protein complex binding 0.0341925447010603 bayes_pls_golite062009
protein heterodimerization activity 0.0195372592716698 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [198-268]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GMGAFGGSGG DSDANGTFMD FGVDPSMDPE LAMALRLSME EEQQRQERLR QQQQQQDQPE  60
   61 QSEQPEQHQD K

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.330 a.22.1 Histone-fold
View Download 0.326 f.13.1 Family A G protein-coupled receptor-like
View Download 0.314 f.14.1 Voltage-gated potassium channels
View Download 0.390 a.126.1 Serum albumin-like
View Download 0.291 a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.287 a.4.5 "Winged helix" DNA-binding domain
View Download 0.286 d.52.7 Ribosome-binding factor A, RbfA
View Download 0.273 a.64.1 Saposin
View Download 0.256 a.22.1 Histone-fold
View Download 0.239 f.15.1 Small-conductance potassium channel
View Download 0.203 a.105.1 FIS-like


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle