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View Structure Prediction Details

Protein: ERG9
Organism: Saccharomyces cerevisiae
Length: 444 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ERG9.

Description E-value Query
Range
Subject
Range
FDFT_YEAST - Squalene synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG9 PE=1 SV=2
ERG9 - Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moie...
0.0 [1..444] [1..444]
gi|9955387 - gi|9955387|dbj|BAB12207.1| squalene synthase [Candida glabrata]
0.0 [1..437] [1..440]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [1..439] [1..405]
gi|1552717 - gi|1552717|gb|AAB08578.1| squalene synthase [Nicotiana tabacum]
0.0 [1..397] [1..391]
FDFT_NICBE - Squalene synthase OS=Nicotiana benthamiana PE=2 SV=1
0.0 [1..397] [1..391]
gi|5360655 - gi|5360655|dbj|BAA82093.1| squalene synthase [Solanum tuberosum]
0.0 [1..397] [1..391]
FDFT_CYBJA - Squalene synthase OS=Cyberlindnera jadinii GN=ERG9 PE=3 SV=1
0.0 [1..437] [1..437]

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Predicted Domain #1
Region A:
Residues: [1-164]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKLLQLALH PVEMKAALKL KFCRTPLFSI YDQSTSPYLL HCFELLNLTS RSFAAVIREL  60
   61 HPELRNCVTL FYLILRALDT IEDDMSIEHD LKIDLLRHFH EKLLLTKWSF DGNAPDVKDR 120
  121 AVLTDFESIL IEFHKLKPEY QEVIKEITEK MGNGMADYIL DENY

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [180-199]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HYVAGLVGDG LTRLIVIAKF 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 917.9897
Match: 1ezfA_
Description: Squalene synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
prenyltransferase activity 5.34003736022396 bayes_pls_golite062009
farnesyl-diphosphate farnesyltransferase activity 5.04441642023356 bayes_pls_golite062009
geranyltranstransferase activity 3.86169009960142 bayes_pls_golite062009
farnesyltranstransferase activity 3.11591733497708 bayes_pls_golite062009
catalytic activity 2.4040324437254 bayes_pls_golite062009
dimethylallyltranstransferase activity 1.91559289231283 bayes_pls_golite062009
transferase activity, transferring alkyl or aryl (other than methyl) groups 1.82540911622956 bayes_pls_golite062009
transferase activity 1.77738506203957 bayes_pls_golite062009
binding 0.0206192709356209 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [165-179]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLNGLQTVHD YDVYC

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [200-444]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ANESLYSNEQ LYESMGLFLQ KTNIIRDYNE DLVDGRSFWP KEIWSQYAPQ LKDFMKPENE  60
   61 QLGLDCINHL VLNALSHVID VLTYLAGIHE QSTFQFCAIP QVMAIATLAL VFNNREVLHG 120
  121 NVKIRKGTTC YLILKSRTLR GCVEIFDYYL RDIKSKLAVQ DPNFLKLNIQ ISKIEQFMEE 180
  181 MYQDKLPPNV KPNETPIFLK VKERSRYDDE LVPTQQEEEY KFNMVLSIIL SVLLGFYYIY 240
  241 TLHRA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 917.9897
Match: 1ezfA_
Description: Squalene synthase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle