YRC Public Data Repository - Protein Structure Prediction

Protein:	PTH1
Organism:	Saccharomyces cerevisiae
Length:	190 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PTH1.

Description	E-value	Query Range	Subject Range
gi\|224500336 - gi\|224500336\|ref\|ZP_03668685.1\| peptidyl-tRNA hydrolase [Listeria monocytogenes Finland 1988] gi\|224503467 - gi\|224503467\|ref\|ZP_03671774.1\| peptidyl-tRNA hydrolase [Listeria monocytogenes FSL R2-561] PTH_LISMO - Peptidyl-tRNA hydrolase OS=Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) GN=pth ... gi\|255028170 - gi\|255028170\|ref\|ZP_05300121.1\| peptidyl-tRNA hydrolase [Listeria monocytogenes LO28] gi\|47096206, gi\|... - gi\|47096206\|ref\|ZP_00233805.1\| peptidyl-tRNA hydrolase [Listeria monocytogenes str. 1/2a F6854], gi\|... PTH_LISMO - Peptidyl-tRNA hydrolase OS=Listeria monocytogenes GN=pth PE=3 SV=1 gi\|254901002, gi... - gi\|254901002\|ref\|ZP_05260926.1\| peptidyl-tRNA hydrolase [Listeria monocytogenes J0161], gi\|153186165... gi\|153189380, gi... - gi\|254913930\|ref\|ZP_05263942.1\| peptidyl-tRNA hydrolase [Listeria monocytogenes J2818], gi\|153189380... gi\|153177868, gi... - gi\|254938279\|ref\|ZP_05269976.1\| peptidyl-tRNA hydrolase [Listeria monocytogenes F6900], gi\|153177868...	2.0E-61	[8..188]	[3..171]
gi\|25319122 - pir\|\|AB1912 peptidyl-tRNA hydrolase [imported] - Nostoc sp. (strain PCC 7120) PTH_NOSS1 - Peptidyl-tRNA hydrolase OS=Nostoc sp. (strain PCC 7120 / UTEX 2576) GN=pth PE=3 SV=1	5.0E-61	[6..186]	[3..179]
PTH_BACSU - Peptidyl-tRNA hydrolase OS=Bacillus subtilis GN=spoVC PE=3 SV=1 gi\|221317118 - gi\|221317118\|ref\|ZP_03598412.1\| peptidyl-tRNA hydrolase [Bacillus subtilis subsp. subtilis str. JH64... gi\|221321381 - gi\|221321381\|ref\|ZP_03602675.1\| peptidyl-tRNA hydrolase [Bacillus subtilis subsp. subtilis str. SMY] PTH_BACSU - Peptidyl-tRNA hydrolase OS=Bacillus subtilis (strain 168) GN=spoVC PE=3 SV=1 gi\|221312185 - gi\|221312185\|ref\|ZP_03593990.1\| peptidyl-tRNA hydrolase [Bacillus subtilis subsp. subtilis str. NCIB...	8.0E-61	[7..190]	[2..174]
PTH_LISIN - Peptidyl-tRNA hydrolase OS=Listeria innocua GN=pth PE=3 SV=1 PTH_LISIN - Peptidyl-tRNA hydrolase OS=Listeria innocua serovar 6a (strain CLIP 11262) GN=pth PE=3 SV=1	4.0E-60	[8..188]	[3..171]
PTH1 - One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respi... gi\|151944133 - gi\|151944133\|gb\|EDN62426.1\| peptidyl-tRNA hydrolase [Saccharomyces cerevisiae YJM789] PTH_YEAST - Peptidyl-tRNA hydrolase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PTH1 PE=1 SV=1 gi\|190405964 - gi\|190405964\|gb\|EDV09231.1\| peptidyl-tRNA hydrolase [Saccharomyces cerevisiae RM11-1a]	8.0E-60	[1..190]	[1..190]
CRS2B_ARATH - Chloroplastic group IIB intron splicing facilitator CRS2-B, chloroplastic OS=Arabidopsis thaliana GN...	3.0E-59	[5..186]	[44..215]
gi\|7448589 - pir\|\|S75738 aminoacyl-tRNA hydrolase (EC 3.1.1.29) - Synechocystis sp. (strain PCC 6803) PTH_SYNY3 - Peptidyl-tRNA hydrolase OS=Synechocystis sp. (strain ATCC 27184 / PCC 6803 / N-1) GN=pth PE=3 SV=1 PTH_SYNY3 - Peptidyl-tRNA hydrolase OS=Synechocystis sp. (strain PCC 6803 / Kazusa) GN=pth PE=3 SV=1	6.0E-59	[6..185]	[3..172]
CRS2_MAIZE - Chloroplastic group IIB intron splicing facilitator CRS2, chloroplastic OS=Zea mays GN=CRS2 PE=1 SV=...	7.0E-59	[5..185]	[60..233]
PTH_BACHD - Peptidyl-tRNA hydrolase OS=Bacillus halodurans GN=pth PE=3 SV=1 PTH_BACHD - Peptidyl-tRNA hydrolase OS=Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 91...	9.0E-59	[8..188]	[3..172]

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Predicted Domain #1

Region A:
Residues: [1-99]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGKWRLVLT GIGNPEPQYA GTRHNVGLYM LELLRKRLGL QGRTYSPVPN TGGKVHYIED  60
   61 EHCTILRSDG QYMNLSGEQV CKVWARYAKY QARHVVIHD

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [111-140]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RAPSTSIRGH NGLRSLLKCS GGRVPFAKLA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	130.502279
Match:	2pth__
Description:	Peptidyl-tRNA hydrolase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
aminoacyl-tRNA hydrolase activity	2.30458185525664	bayes_pls_golite062009
catalytic activity	1.41033217274476	bayes_pls_golite062009
binding	1.31642757964381	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	0.904773408466145	bayes_pls_golite062009
protein binding	0.606551407946731	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [100-110]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELSVACGKVQ L

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [141-190]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IGIGREPGSR SRDPASVSRW VLGALTPQEL QTLLTQSEPA AWRALTQYIS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	130.502279
Match:	2pth__
Description:	Peptidyl-tRNA hydrolase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: