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View Structure Prediction Details

Protein: YSP1
Organism: Saccharomyces cerevisiae
Length: 1228 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YSP1.

Description E-value Query
Range		 Subject
Range
YSP1 - Mitochondrial protein with a potential role in promoting mitochondrial fragmentation during programm...
LAM1_YEAST - Membrane-anchored lipid-binding protein LAM1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c...
 0.0 [1..1228] [1..1228]
YEE2_SCHPO - Uncharacterized PH domain-containing protein C19A8.02 OS=Schizosaccharomyces pombe (strain 972 / ATC...
SPAC19A8.02 - transcriptional coactivator
 0.0 [10..801] [14..804]
gi|6474062 - gi|6474062|dbj|BAA87211.1| Hypothetical protein [Schizosaccharomyces pombe]
 2.0E-83 [498..743] [1..235]
gi|12697977 - gi|12697977|dbj|BAB21807.1| KIAA1716 protein [Homo sapiens]
 3.0E-70 [25..556] [18..502]
AGD2_ARATH - ADP-ribosylation factor GTPase-activating protein AGD2 OS=Arabidopsis thaliana GN=AGD2 PE=2 SV=1
 6.0E-67 [18..457] [6..457]

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Predicted Domain #1
Region A:
Residues: [1-113] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHEHKAELRL ITVALNEAST DSPSFRASVN YFHTRMESLS SWMHSTVDYV ENTYKPSFQD  60
   61 FQRIKETLFS QLLPSPILLS NGFVSNQPYT PLLVRDFTRD VSDLSNTVMK IIL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.727 0.389 mitochondrion a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.697 0.001 mitochondrion a.47.2 t-snare proteins
View Download 0.680 0.001 mitochondrion a.7.7 BAG domain
View Download 0.723 0.000 mitochondrion f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.681 N/A N/A a.112.1 Description not found.
View Download 0.668 N/A N/A a.24.2 Aspartate receptor, ligand-binding domain
View Download 0.661 N/A N/A a.24.14 FAT domain of focal adhesion kinase
View Download 0.647 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.612 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.595 N/A N/A d.87.2 CO dehydrogenase flavoprotein C-terminal domain-like
View Download 0.591 N/A N/A a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.581 N/A N/A a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.571 N/A N/A a.47.2 t-snare proteins
View Download 0.555 N/A N/A a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.552 N/A N/A a.7.5 Tubulin chaperone cofactor A
View Download 0.544 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.520 N/A N/A a.24.4 Hemerythrin
View Download 0.499 N/A N/A a.7.7 BAG domain
View Download 0.470 N/A N/A a.22.1 Histone-fold
View Download 0.460 N/A N/A a.60.10 Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
View Download 0.453 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.446 N/A N/A a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.439 N/A N/A a.22.1 Histone-fold
View Download 0.438 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.432 N/A N/A a.7.8 GAT domain
View Download 0.415 N/A N/A a.118.7 14-3-3 protein
View Download 0.407 N/A N/A f.25.1 Cytochrome c oxidase subunit III-like
View Download 0.399 N/A N/A d.58.19 Bacterial exopeptidase dimerisation domain
View Download 0.397 N/A N/A a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.396 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.391 N/A N/A a.26.1 4-helical cytokines
View Download 0.389 N/A N/A a.2.1 GreA transcript cleavage protein, N-terminal domain
View Download 0.382 N/A N/A a.7.1 Spectrin repeat
View Download 0.380 N/A N/A a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.378 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.373 N/A N/A a.24.3 Cytochromes
View Download 0.365 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.354 N/A N/A f.1.3 delta-Endotoxin (insectocide), N-terminal domain
View Download 0.352 N/A N/A f.18.1 F1F0 ATP synthase subunit A
View Download 0.351 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.348 N/A N/A a.25.1 Ferritin-like
View Download 0.348 N/A N/A a.26.1 4-helical cytokines
View Download 0.345 N/A N/A a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.345 N/A N/A a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.344 N/A N/A a.24.4 Hemerythrin
View Download 0.340 N/A N/A f.17.2 Cytochrome c oxidase subunit II-like, transmembrane region
View Download 0.340 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.338 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.337 N/A N/A f.14.1 Voltage-gated potassium channels
View Download 0.335 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.334 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.331 N/A N/A a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.327 N/A N/A a.47.2 t-snare proteins
View Download 0.327 N/A N/A d.58.7 RNA-binding domain, RBD
View Download 0.326 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.322 N/A N/A a.26.1 4-helical cytokines
View Download 0.317 N/A N/A a.47.2 t-snare proteins
View Download 0.317 N/A N/A f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.316 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.311 N/A N/A a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.309 N/A N/A a.24.3 Cytochromes
View Download 0.307 N/A N/A a.7.8 GAT domain
View Download 0.302 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.300 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.300 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.296 N/A N/A a.19.1 Fertilization protein
View Download 0.294 N/A N/A a.26.1 4-helical cytokines
View Download 0.293 N/A N/A f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.293 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.292 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.292 N/A N/A a.7.8 GAT domain
View Download 0.292 N/A N/A a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.290 N/A N/A a.112.1 Description not found.
View Download 0.289 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.288 N/A N/A a.29.3 Acyl-CoA dehydrogenase C-terminal domain-like
View Download 0.288 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.286 N/A N/A b.88.1 Mss4-like
View Download 0.284 N/A N/A b.40.4 Nucleic acid-binding proteins
View Download 0.281 N/A N/A a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.279 N/A N/A a.7.5 Tubulin chaperone cofactor A
View Download 0.279 N/A N/A f.1.3 delta-Endotoxin (insectocide), N-terminal domain
View Download 0.278 N/A N/A d.96.1 Tetrahydrobiopterin biosynthesis enzymes-like
View Download 0.277 N/A N/A b.88.1 Mss4-like
View Download 0.277 N/A N/A a.22.1 Histone-fold
View Download 0.277 N/A N/A a.24.1 Apolipoprotein
View Download 0.276 N/A N/A a.7.1 Spectrin repeat
View Download 0.276 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.274 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.274 N/A N/A a.130.1 Chorismate mutase II
View Download 0.270 N/A N/A a.13.1 alpha-2-Macroglobulin receptor associated protein (RAP) domain 1
View Download 0.269 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.267 N/A N/A a.24.14 FAT domain of focal adhesion kinase
View Download 0.263 N/A N/A a.123.1 Nuclear receptor ligand-binding domain
View Download 0.262 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.262 N/A N/A a.2.7 tRNA-binding arm
View Download 0.259 N/A N/A a.41.1 Domain of poly(ADP-ribose) polymerase
View Download 0.252 N/A N/A f.14.1 Voltage-gated potassium channels
View Download 0.250 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.248 N/A N/A b.88.1 Mss4-like
View Download 0.247 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.247 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.247 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.246 N/A N/A a.7.7 BAG domain
View Download 0.246 N/A N/A f.14.1 Voltage-gated potassium channels
View Download 0.243 N/A N/A a.149.1 RNase III endonuclease catalytic domain
View Download 0.242 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.242 N/A N/A f.14.1 Voltage-gated potassium channels
View Download 0.241 N/A N/A a.77.1 DEATH domain
View Download 0.241 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.241 N/A N/A a.2.7 tRNA-binding arm
View Download 0.240 N/A N/A a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.239 N/A N/A a.47.2 t-snare proteins
View Download 0.239 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.238 N/A N/A a.40.1 Calponin-homology domain, CH-domain
View Download 0.237 N/A N/A d.8.1 Urease, gamma-subunit
View Download 0.237 N/A N/A a.47.2 t-snare proteins
View Download 0.235 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.235 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.235 N/A N/A a.112.1 Description not found.
View Download 0.234 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.231 N/A N/A a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.229 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.227 N/A N/A f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.226 N/A N/A a.7.1 Spectrin repeat
View Download 0.225 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.225 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.223 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.222 N/A N/A a.7.8 GAT domain
View Download 0.220 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.220 N/A N/A c.114.1 YchN-like
View Download 0.220 N/A N/A a.22.1 Histone-fold
View Download 0.219 N/A N/A a.7.5 Tubulin chaperone cofactor A
View Download 0.219 N/A N/A f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.217 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.217 N/A N/A a.7.5 Tubulin chaperone cofactor A
View Download 0.217 N/A N/A a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.216 N/A N/A f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.214 N/A N/A a.29.2 Bromodomain
View Download 0.214 N/A N/A a.48.1 N-terminal domain of cbl (N-cbl)
View Download 0.214 N/A N/A a.63.1 Apolipophorin-III
View Download 0.213 N/A N/A a.1.1 Globin-like
View Download 0.211 N/A N/A a.46.1 Methionine synthase domain
View Download 0.211 N/A N/A a.19.1 Fertilization protein
View Download 0.209 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.209 N/A N/A f.14.1 Voltage-gated potassium channels
View Download 0.209 N/A N/A a.19.1 Fertilization protein
View Download 0.209 N/A N/A a.19.1 Fertilization protein
View Download 0.207 N/A N/A a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.207 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.206 N/A N/A a.19.1 Fertilization protein
View Download 0.201 N/A N/A a.7.7 BAG domain

Predicted functions:

Term Confidence Notes
protein binding 3.17213698546013 bayes_pls_golite062009
binding 2.86147407357315 bayes_pls_golite062009
transcription regulator activity 1.50756932992573 bayes_pls_golite062009
nucleic acid binding 1.2749362891779 bayes_pls_golite062009
DNA binding 1.18878662922624 bayes_pls_golite062009
protein domain specific binding 0.236765394237244 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.198922924806251 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [114-189] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDENSQYTAA LSALSSDAIN PYFNKRKTFE YYQRKYDSFL TDFLAATNDG NTLIPQNLQN  60
   61 ETFKLVDIKH KYIEAS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.0
Match: 1pbv__
Description: Exchange factor ARNO
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.95502209146398 bayes_pls_golite062009
DNA binding 4.49877554292304 bayes_pls_golite062009
nucleic acid binding 4.4138116788102 bayes_pls_golite062009
transcription factor activity 3.78905634607011 bayes_pls_golite062009
transcription activator activity 3.19708783401986 bayes_pls_golite062009
binding 3.09940998297931 bayes_pls_golite062009
sequence-specific DNA binding 3.07549097279613 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.10135825467854 bayes_pls_golite062009
protein binding 1.80415286835431 bayes_pls_golite062009
transcription repressor activity 1.72704408652215 bayes_pls_golite062009
transcription factor binding 0.35726633913804 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.18158516638045 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [190-296] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDLTEAISLM KVNLDKFLIE TIDIVRKNNV ITTKDTKDVI DITPELTETL KDWTDWIESN  60
   61 LQTLQALSSK LSEAKYAILK LSLARMKPSR LIQDYDLKSI QNLKFNL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.0
Match: 1pbv__
Description: Exchange factor ARNO
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [297-467] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKSISNGNNS EEKGLSGWLY MKTTVGHDPK RVVWVRRWCF LQNNVFGVFS LSPSKTYVEE  60
   61 TDKFGILWIT VEYLPKEPRN FCFKLRIQNP NCKTEEENTY IDIILQAESI DELKSWINTL 120
  121 TSHKRIALSI KEENDPRYQL ARKKIEPQFF EFASSSSTST DKLLTSFSSK T

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.0
Match: 1eazA_
Description: Tapp1
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [468-571] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTLVEELKKN YMSEDDIYSI IDNKAYHLRV ISTPIATQLT HLALFSTFLS VSNYYPCATQ  60
   61 ANTWGTANWN DLSYLVNPLK GSSVHKPATV SNSSRFSVSY PDYY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2.39794
Match: 1dcqA_
Description: Pyk2-associated protein beta; Pyk2-associated protein beta ARF-GAP domain
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [572-1228] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PYSLKVDDIQ FRSIFFSVNH DFLQVPKELV LLRYSSVWCP NNKQKFASMA FVTLNHIYVY  60
   61 LNISGFSYLR RIDLLDIDSI EYDKSPKHVS SRMLHMQRGD GLRFNMSVFF TDRRAVASKL 120
  121 QFLIENKAMH IPKGEKEVLE IFQELDEEIE NEKKIIKDNL SESEHYSKDY DYLLKSTYDH 180
  181 HFENTNETPM ELMSRKLRLE REAWCYFQDN FKVGSKTLFH VLFGDKSQVF PSSLFLCKKG 240
  241 SNLNNNSYWE RIRRAKEDAS CQFELCRKLQ FQLNRTSNFI KDLLWLKDDN DNFKLVLQQR 300
  301 VTKIKQGYYF EVEEGPIIVK FPLCHPLLLR VRFIIAECIT SQGESLKKCD LAILYDFNYV 360
  361 ESIDKLNTKV EKLWLFERIH LNWALRYCKL EHSEINRKTR EYLKKFNDRE KMSDVIKLCG 420
  421 FLGVLPKERI ENDEKAGDFM QPVYINYDFL SLSKIFTKLT VFYLSSVIIK TMKVLLAMVM 480
  481 VIFKCFSKVN KTLYYCLLIS AVTNLFFVGK SIHSYFSVKS AETLFQNYAN GDQRGLQIMH 540
  541 RSLTVPDLNL LTRKMMDNDQ ENPVFKRFDE DKNAYQYKGT RQEIAIKRNQ VLTELKILQN 600
  601 TEKELVQGSY RKFIITERDK CITTQNEIFD LWINDTKLQD YCMACFAEYN RLSAIPV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle