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View Structure Prediction Details

Protein: RTT107
Organism: Saccharomyces cerevisiae
Length: 1070 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RTT107.

Description E-value Query
Range
Subject
Range
RTT107 - Protein implicated in Mms22-dependent DNA repair during S phase, DNA damage induces phosphorylation ...
RT107_YEAST - Regulator of Ty1 transposition protein 107 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ...
0.0 [1..1070] [1..1070]
BRC1_SCHPO - BRCT-containing protein 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=brc1 PE=1 SV=1
brc1 - BRCT domain protein Brc1
0.0 [69..1060] [59..869]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [69..634] [51..579]
gi|85085755 - gi|85085755|ref|XP_957563.1| hypothetical protein ( (AL356172) conserved hypothetical protein [Neuro...
gi|28918656, gi|... - gi|32405260|ref|XP_323243.1| hypothetical protein ( (AL356172) conserved hypothetical protein [Neuro...
0.0 [69..634] [58..586]
gi|15223895, gi|... - pir||B96802 hypothetical protein F2P24.3 [imported] - Arabidopsis thaliana, gi|15223895|ref|NP_1778...
2.0E-85 [69..494] [137..583]
gi|553596 - gi|553596|gb|AAA59888.1| cellular myosin heavy chain [Homo sapiens]
5.0E-67 [488..926] [921..1337]
mus101-PA - The gene mutagen-sensitive 101 is referred to in FlyBase by the symbol Dmel\mus101 (CG11156, FBgn000...
2.0E-66 [266..928] [611..1298]

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Predicted Domain #1
Region A:
Residues: [1-119]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTSLLFEQL NFLILVAAEA ELPIAHSTRK LLMDNSCNNC QIYELYNENL KDVKTDKDWF  60
   61 MNKFGPQTVH FVISNTINFP FYKIVYFDLL IPVVSHTWVQ DSVKTKRHLR TNMYSPNPF

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.32
Match: 1l0bA
Description: Breast cancer associated protein, BRCA1
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [120-260]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HLLRDCQVYI SKSSFNKCEY ILYSDLLHLL GGTLVNYISN RTTHVIVQSP QDPIIATVSK  60
   61 LTFGSFSSSS TNKHTEKPLR EWKFVYPIWI LYHFKMAKPL KGELATLCEL DMQDTSEEQL 120
  121 FAKWEEVIGD KQTSSSQLTL H

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.32
Match: 1l0bA
Description: Breast cancer associated protein, BRCA1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
damaged DNA binding 2.78264840479873 bayes_pls_golite062009
binding 2.39904249850929 bayes_pls_golite062009
nucleic acid binding 2.01217461524277 bayes_pls_golite062009
DNA binding 1.94626538619156 bayes_pls_golite062009
transcription regulator activity 1.6615655042871 bayes_pls_golite062009
protein binding 1.25126059595954 bayes_pls_golite062009
sequence-specific DNA binding 0.87932139868144 bayes_pls_golite062009
telomeric DNA binding 0.53051501110858 bayes_pls_golite062009
structure-specific DNA binding 0.436014478237905 bayes_pls_golite062009
transcription activator activity 0.355931500039388 bayes_pls_golite062009
ligase activity 0.334005199756535 bayes_pls_golite062009
transcription factor binding 0.27424353108553 bayes_pls_golite062009
transcription repressor activity 0.210876161781476 bayes_pls_golite062009
catalytic activity 0.17721113579921 bayes_pls_golite062009
double-stranded DNA binding 0.163902958036495 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [261-359]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNKTLFKNHH FAISPDLNFF TPLYWFLKGF IEDLDGKVTP LSFSDDLKSV YQAFPDIDCY  60
   61 IGHSANSPIL EKTKSIKPEI HVGNVSWLFY MFALQKFTP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [360-452]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VSQCKLIHQP FHAKLFTSKE LTVAYTNYFG SQRFYIQRLV EILGGLSTPE LTRKNTHLIT  60
   61 KSTIGKKFKV AKKWSLDPQN AIIVTNHMWL EQC

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.91
Match: 1dgsA
Description: NAD+-dependent DNA ligase, domain 3; NAD+-dependent DNA ligase; Adenylation domain of NAD+-dependent DNA ligase
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [453-747]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YMNNSKLNPK DSRFQNFKLD DNMGWNIGQI GMDHSSLPTP KNLSMVTYDT QSISEKPPPT  60
   61 NDQMDQINDN TNVLSKKDGT PISSFENSID EKIDKLQKIS GEVAVTHSGD LERSFVSRPS 120
  121 RASFPVVDSK KSNLQKKDSN SDISMETEVF CEGHEKREEK EFTKPITEYD APKKQEIREQ 180
  181 SRKKNDIDYK KEEEETELQV QLGQRTKREI KTSKKNEKEK ETNECHIEVD QMTNEKQGEE 240
  241 STGKLISTED VTSKKDTDKF SHLFEGLSDN DDHINDEKPA VNSKYTTPKT SQNIT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.39794
Match: 1i84S_
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [748-834]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGVDTPTTAQ TQVFMPSSGN SRLAKTQAAK RLHTDIESLN EFQKNFKRKR IDSEEISLSQ  60
   61 DVERSNNNKE LATKAEKILA RFNELPN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.30103
Match: 2tmaA_
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #7
Region A:
Residues: [835-1070]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YDLKAVCTGC FHDGFNEVDI EILNQLGIKI FDNIKETDKL NCIFAPKILR TEKFLKSLSF  60
   61 EPLKFALKPE FIIDLLKQIH SKKDKLSQIN INLFDYEING INESIISKTK LPTKVFERAN 120
  121 IRCINLVNDI PGGVDTIGSV LKAHGIEKIN VLRSKKCTFE DIIPNDVSKQ ENGGIFKYVL 180
  181 IVTKASQVKK FTKLINDRDK NETILIVEWN WCVESIFHLN VDFTSKKNVL YQKKNN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle