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View Structure Prediction Details

Protein: APL6
Organism: Saccharomyces cerevisiae
Length: 809 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for APL6.

Description E-value Query
Range
Subject
Range
APL6 - Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the ...
gi|207344904 - gi|207344904|gb|EDZ71892.1| YGR261Cp-like protein [Saccharomyces cerevisiae AWRI1631]
AP3B_YEAST - AP-3 complex subunit beta OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=APL6 PE=1 SV=2
gi|190406735 - gi|190406735|gb|EDV10002.1| clathrin assembly complex beta adaptin component [Saccharomyces cerevisi...
0.0 [1..770] [1..770]
gi|25404261, gi|... - gi|4249386|gb|AAD14483.1|AAD14483 Strong similarity to gb|AF061286 gamma-adaptin 1 from Arabidopsis ...
0.0 [6..799] [8..786]
gi|114663571, gi... - gi|114663577|ref|XP_001171453.1| PREDICTED: adaptor-related protein complex 1, gamma 1 subunit isofo...
gi|71773010, gi|... - gi|71773010|ref|NP_001025178.1| adaptor-related protein complex 1, gamma 1 subunit isoform a [Homo s...
0.0 [42..800] [29..743]
AP2B1_MOUSE - AP-2 complex subunit beta OS=Mus musculus GN=Ap2b1 PE=1 SV=1
0.0 [30..780] [1..695]

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Predicted Domain #1
Region A:
Residues: [1-122]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVDSIHRIAS ALDTAKVITR EAAAVATSKL GESSYTYYSQ NINPQQLVTL LNSRNSREVR  60
   61 DAMKRIISIM ASDDDSIDVQ LYFADVVKNI TTNDTKVKRL IHLYLLRFAE NDPNLTLLSI 120
  121 NS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 386.228787
Match: 1gw5B_
Description: Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [123-223]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LQKSLSDSNS ELRCFALSAL SDMKMSSLAP IILHTVKKLV TDPSAMVRGE VALAIIKLYR  60
   61 AGKNDYHEEL LDILKELMAD TDPKVISCAV LAYKECYADH L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 386.228787
Match: 1gw5B_
Description: Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [224-390]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELLHGHFRRY CRIIKQLDSW SQSYLIELLI KYCKQYLPKP TVVDKSSEGS PRSCPLPDKY  60
   61 NEIEYPSYEV VNDPDLDLFL QSLNCLIYSS NPTVILSCCN ALYQLASPLQ MKNTKFIEAL 120
  121 VRTVTMTENQ GNKEMLLQAI HFLSILDQTL FLPYTKKFYV FPKDPIV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 386.228787
Match: 1gw5B_
Description: Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [391-576]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASIWKIQILS TLINESNVKE IFKELKYYVA SAHFPENVVI MAVKSLSRCG QLSTSWESHV  60
   61 MKWLIDHMES HNLSASVLDA YVNVIRMLVQ KNPTKHLRII FKLADLLTVQ TSLADNARAG 120
  121 IVWLFGEIAS IEFKICPDVL RRLIQNFSNE GPETRCQILV LSAKLLSYDI DNFKQAQVTG 180
  181 SEENNQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 386.228787
Match: 1gw5B_
Description: Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [577-722]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPPYYDFSGS RISQMYNAVL YLAKYDDEFD IRDRARMISS LFDSGKYEIV SLLLQAPKPT  60
   61 ARSDDFIVSA RLETHTPEIK EFFRMLPWNT EITEVGETGN DIREGAELKD YNKYKKSFSS 120
  121 QSFITNNSAR SFTSSSNAKL TGINDG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [723-809]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSNSISGKGN VNTFTSQNGK KYRLQSLDEF FSDIPERKSK PRKIIKVVEE SSDEDEDESE  60
   61 ESSDDDEYSD SSLGTSSSGT SSSHLEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.154902
Match: 1iu1A_
Description: Gamma1-adaptin domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle