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View Structure Prediction Details

Protein: APL6
Organism: Saccharomyces cerevisiae
Length: 809 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for APL6.

Description E-value Query
Range
Subject
Range
APL6 - Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the ...
gi|207344904 - gi|207344904|gb|EDZ71892.1| YGR261Cp-like protein [Saccharomyces cerevisiae AWRI1631]
AP3B_YEAST - AP-3 complex subunit beta OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=APL6 PE=1 SV=2
gi|190406735 - gi|190406735|gb|EDV10002.1| clathrin assembly complex beta adaptin component [Saccharomyces cerevisi...
0.0 [1..770] [1..770]
gi|25404261, gi|... - gi|4249386|gb|AAD14483.1|AAD14483 Strong similarity to gb|AF061286 gamma-adaptin 1 from Arabidopsis ...
0.0 [6..799] [8..786]
gi|114663571, gi... - gi|114663577|ref|XP_001171453.1| PREDICTED: adaptor-related protein complex 1, gamma 1 subunit isofo...
gi|71773010, gi|... - gi|71773010|ref|NP_001025178.1| adaptor-related protein complex 1, gamma 1 subunit isoform a [Homo s...
0.0 [42..800] [29..743]
AP2B1_MOUSE - AP-2 complex subunit beta OS=Mus musculus GN=Ap2b1 PE=1 SV=1
0.0 [30..780] [1..695]

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Predicted Domain #1
Region A:
Residues: [1-122]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVDSIHRIAS ALDTAKVITR EAAAVATSKL GESSYTYYSQ NINPQQLVTL LNSRNSREVR  60
   61 DAMKRIISIM ASDDDSIDVQ LYFADVVKNI TTNDTKVKRL IHLYLLRFAE NDPNLTLLSI 120
  121 NS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 386.228787
Match: 1gw5B_
Description: Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [123-223]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LQKSLSDSNS ELRCFALSAL SDMKMSSLAP IILHTVKKLV TDPSAMVRGE VALAIIKLYR  60
   61 AGKNDYHEEL LDILKELMAD TDPKVISCAV LAYKECYADH L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 386.228787
Match: 1gw5B_
Description: Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [224-390]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELLHGHFRRY CRIIKQLDSW SQSYLIELLI KYCKQYLPKP TVVDKSSEGS PRSCPLPDKY  60
   61 NEIEYPSYEV VNDPDLDLFL QSLNCLIYSS NPTVILSCCN ALYQLASPLQ MKNTKFIEAL 120
  121 VRTVTMTENQ GNKEMLLQAI HFLSILDQTL FLPYTKKFYV FPKDPIV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 386.228787
Match: 1gw5B_
Description: Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [391-576]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASIWKIQILS TLINESNVKE IFKELKYYVA SAHFPENVVI MAVKSLSRCG QLSTSWESHV  60
   61 MKWLIDHMES HNLSASVLDA YVNVIRMLVQ KNPTKHLRII FKLADLLTVQ TSLADNARAG 120
  121 IVWLFGEIAS IEFKICPDVL RRLIQNFSNE GPETRCQILV LSAKLLSYDI DNFKQAQVTG 180
  181 SEENNQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 386.228787
Match: 1gw5B_
Description: Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [577-722]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPPYYDFSGS RISQMYNAVL YLAKYDDEFD IRDRARMISS LFDSGKYEIV SLLLQAPKPT  60
   61 ARSDDFIVSA RLETHTPEIK EFFRMLPWNT EITEVGETGN DIREGAELKD YNKYKKSFSS 120
  121 QSFITNNSAR SFTSSSNAKL TGINDG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.304 0.089 Golgi to vacuole transport a.118.9 ENTH/VHS domain
View Download 0.286 0.009 Golgi to vacuole transport a.118.11 Cytochrome c oxidase subunit E
View Download 0.274 0.009 Golgi to vacuole transport a.95.1 Influenza virus matrix protein M1

Predicted Domain #6
Region A:
Residues: [723-809]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DSNSISGKGN VNTFTSQNGK KYRLQSLDEF FSDIPERKSK PRKIIKVVEE SSDEDEDESE  60
   61 ESSDDDEYSD SSLGTSSSGT SSSHLEL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.154902
Match: 1iu1A_
Description: Gamma1-adaptin domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle