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View Structure Prediction Details

Protein: CCH1
Organism: Saccharomyces cerevisiae
Length: 2039 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CCH1.

Description E-value Query
Range
Subject
Range
gi|508195 - gi|508195|emb|CAA84341.1| voltage-dependent L-type Ca channel alpha 1 subunit [Homo sapiens]
0.0 [422..1969] [108..1677]
gi|14718596 - gi|14718596|gb|AAK72959.1|AF370009_1 voltage-gated calcium channel pore forming subunit CaV1.3alpha1...
0.0 [422..1950] [101..1643]
gi|15131669 - gi|15131669|emb|CAC48390.1| voltage-gated calcium channel alpha1 subunit [Mesocricetus auratus]
0.0 [422..1906] [101..1587]
gi|27806135, gi|... - gi|27806135|ref|NP_776883.1| voltage-gated sodium channel type V alpha [Bos taurus], gi|18477465|emb...
0.0 [709..1935] [669..1930]
CAC1S_RABIT - Voltage-dependent L-type calcium channel subunit alpha-1S OS=Oryctolagus cuniculus GN=CACNA1S PE=1 S...
0.0 [422..1969] [35..1582]
gi|691720 - gi|691720|gb|AAA62612.1| murine erythroleukemia cardiac calcium channel
0.0 [554..1969] [1..1407]

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Predicted Domain #1
Region A:
Residues: [1-232]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQGRKRTLTE PFEPNTNPFG DNAAVMTENV EDNSETDGNR LESKPQALVP PALNIVPPES  60
   61 SIHSTEEKKG DEYNGNDKDS SLISNIFRTR VGRSSHENLS RPKLSLKTAS FGAAESSRRN 120
  121 VSPSTKSAKS SSQYIDLNDE RLRRRSFSSY SRSSSRRVSN SPSSTDRPPR SAKVLSLIAA 180
  181 DDMDDFEDLQ KGFKSAIDEE GLTWLPQLKS EKSRPVSDVG EDRGEGEQES IP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [233-365]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVHTPNVGAS ATPGSIHLTP EPAQNGSVSE GLEGSINNSR KKPSPKFFHH LSPQKEDKDQ  60
   61 TEVIEYAEDI LDFETLQRKL ESRPFVLYGH SLGVFSPTNP LRIKIARFLL HRRYSLLYNT 120
  121 LLTFYAILLA IRT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.0
Match: 1exbE_
Description: KV1.1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [366-426]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YNPHNVVFLY RFSNWTDYFI FILSACFTGN DIAKIIAFGF WDDSEMFKAY GREYKSILQR  60
   61 S

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.402 0.816 calcium ion transport a.4.1 Homeodomain-like

Predicted Domain #4
Region A:
Residues: [427-611]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GIMKLYIYLR EKYGRKLIDF IIPFRIISPG EETKYQRSSL STSLTKPYGA KENQRPFGTP  60
   61 RAFARSSWNR IDLVSSVSFW LGMFLSIKSY DTKTGIRIFK PLAILRILRL VNVDTGMPSI 120
  121 LRGLKYGIPQ LVNVSSMLVY FWIFFGILGV QIFQGSFRRQ CVWFNPEDPT DTYQYDMQFC 180
  181 GGYLD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [612-1110]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PVTKRKQNYI YEDGSEGSVS KGFLCPQYSK CVSNANPYNG RISFDNIVNS MELVFVIMSA  60
   61 NTFTDLMYYT MDSDEMAACL FFIVCIFVLT IWLLNLLIAV LVSSFEIANE EYKKKKFIYG 120
  121 SRKTGYVARI VTGYWKYFKL KANQTKFPNW SQKGLAIYSH VEFIFVILII CDIGMRASVK 180
  181 VSTSANCNNI LLKTDRGISI VLFIESLARL VLYLPNMWKF LTKPSYVYDF IISIITLVIS 240
  241 CLAVEGVLGH MYAWLSIFHI SRFYRVIISF NLTKKLWKQI LSNGVMIWNL SSFYFFFTFL 300
  301 VAIIMAVYFE GVIPPEEMAD QPFGMYSLPN SFLSLFIIGS TENWTDILYA LQKHSPNISS 360
  361 TFFCSVFFII WFLLSNSVIL NIFIALISES MEVKEEEKRP QQIKHYLKFV YPQKIQEYTH 420
  421 ASLVARIRKK FFGGHRNEDT RDFKQFLMRG TAIMNIAQNM GELADEFKEP PSENLFKKGL 480
  481 SKLTIGVPSL KRLRMFANN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1111-1197]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PFYKNSDVVF TETNDINGRT YILELNEYED EKLDYLKKYP LFNYSYYFFS PQHRFRRFCQ  60
   61 RLVPPSTGKR TDGSRFFEDS TDLYNKR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
metal ion transmembrane transporter activity 4.7372448658795 bayes_pls_golite062009
voltage-gated cation channel activity 4.63984862452408 bayes_pls_golite062009
cation transmembrane transporter activity 4.6123766644348 bayes_pls_golite062009
voltage-gated potassium channel activity 4.56176308768245 bayes_pls_golite062009
ion transmembrane transporter activity 4.53708718755887 bayes_pls_golite062009
potassium channel activity 4.51985608289081 bayes_pls_golite062009
voltage-gated ion channel activity 4.5171803357978 bayes_pls_golite062009
voltage-gated channel activity 4.51256290813453 bayes_pls_golite062009
cation channel activity 4.45938408950249 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 4.18703661144599 bayes_pls_golite062009
gated channel activity 3.79587174965364 bayes_pls_golite062009
substrate-specific channel activity 3.72917222310854 bayes_pls_golite062009
ion channel activity 3.48521592747971 bayes_pls_golite062009
passive transmembrane transporter activity 3.39410147300457 bayes_pls_golite062009
channel activity 3.39410147300457 bayes_pls_golite062009
transporter activity 2.77619896060397 bayes_pls_golite062009
transmembrane transporter activity 2.65613366364107 bayes_pls_golite062009
substrate-specific transporter activity 2.3511225030312 bayes_pls_golite062009
inward rectifier potassium channel activity 2.22500563098935 bayes_pls_golite062009
ligand-gated channel activity 1.95018194128504 bayes_pls_golite062009
ligand-gated ion channel activity 1.95018194128504 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [1198-1330]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SYFHHIERDV FVFIFALATI LLIVCSCYVT PLYRMHHKMG TWNWSSALDC AFIGAFSIEF  60
   61 IVKTVADGFI YSPNAYLRNP WNFIDFCVLI SMWINLIAYL KNNGNLSRIF KGLTALRALR 120
  121 CLTISNTARQ TFN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1331-1437]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LVMFDGLNKI FEAGLISLSL LFPFTVWGLS IFKGRLGTCN DGSLGRADCY NEYSNSVFQW  60
   61 DIMSPRVYQQ PYLHLDSFAS AFSSLYQIIS LEGWVDLLEN MMNSSGI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9
Region A:
Residues: [1438-1528]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTPATVMGSA GNALFLVLFN FLSMVFILNL FVSFIVNNQA RTTGSAYFTI EEKAWLESQK  60
   61 LLSQAKPKAI PNLIELSRVR QFFYQLAVEK K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.522879
Match: 1byyA_
Description: Sodium channel IIA
Matching Structure (courtesy of the PDB):

Predicted Domain #10
Region A:
Residues: [1529-1761]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFYYASFLQV VLYLHIIMLL SRSYNPGNLI GYQGVYFMFS TSVFLIQEAL HMCGEGPRLY  60
   61 FRQKWNSIRL SIIIIAFIMN AVAFHVPASH YWFHNIKGFF LLVIFLFIIP QNDTLTELLE 120
  121 TAMASLPPIL SLTYTWGVLF LVYAIALNQI FGLTRLGSNT TDNINFRTVI KSMIVLFRCS 180
  181 FGEGWNYIMA DLTVSEPYCS SDDNSTYTDC GSETYAYLLL MSWNIISMYI FVN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #11
Region A:
Residues: [1762-1891]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFVSLIIGNF SYVYRSGGSR SGINRSEIKK YIEAWSKFDT DGTGELELSY LPRIMHSFDG  60
   61 PLSFKIWEGR LTIKSLVENY MEVNPDDPYD VKIDLIGLNK ELNTIDKAKI IQRKLQYRRF 120
  121 VQSIHYTNAY 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #12
Region A:
Residues: [1892-2039]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NGCIRFSDLL LQIPLYTAYS ARECLGIDQY VHHLYILGKV DKYLENQRNF DVLEMVVTRW  60
   61 KFHCRMKRTI EPEWDVKDPT VSSHISNINV NLEPAPGILE REPIATPRMD YGVNNFMWSP 120
  121 RMNQDSTMEP PEEPIDNNDD SANDLIDR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle