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View Structure Prediction Details

Protein: VAS1
Organism: Saccharomyces cerevisiae
Length: 1104 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VAS1.

Description E-value Query
Range		 Subject
Range
gi|173164 - gi|173164|gb|AAA35207.1| valyl-tRNA synthetase
 0.0 [1..1104] [1..1104]
gi|4590330, gi|4... - gi|4590330|gb|AAD26532.1|AF087680_1 valyl-tRNA synthetase [Mus musculus], gi|4590328|gb|AAD26531.1|A...
 0.0 [54..1102] [211..1262]
gi|15215421, gi|... - gi|168985920|emb|CAQ07253.1| valyl-tRNA synthetase [Homo sapiens], gi|168985661|emb|CAQ10126.1| valy...
 0.0 [54..1102] [211..1263]
SYVM1_ARATH - Valine--tRNA ligase, mitochondrial 1 OS=Arabidopsis thaliana GN=TWN2 PE=2 SV=2
 0.0 [33..1101] [27..1100]
SYVC_TAKRU - Valine--tRNA ligase OS=Takifugu rubripes GN=vars PE=3 SV=1
 0.0 [46..1102] [145..1216]

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Predicted Domain #1
Region A:
Residues: [1-121] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNKWLNTLSK TFTFRLLNCH YRRSLPLCQN FSLKKSLTHN QVRFFKMSDL DNLPPVDPKT  60
   61 GEVIINPLKE DGSPKTPKEI EKEKKKAEKL LKFAAKQAKK NAAATTGASQ KKPKKKKEVE 120
  121 P

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [122-169] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPEFIDKTVP GEKKILVSLD DPALKAYNPA NVESSWYDWW IKTGVFEP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [196-218] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LHIGHALTIA IQDSLIRYNR MKG

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [693-945] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HSLVRDAQGR KMSKSLGNVI DPLDVITGIK LDDLHAKLLQ GNLDPREVEK AKIGQKESYP  60
   61 NGIPQCGTDA MRFALCAYTT GGRDINLDIL RVEGYRKFCN KIYQATKFAL MRLGDDYQPP 120
  121 ATEGLSGNES LVEKWILHKL TETSKIVNEA LDKRDFLTST SSIYEFWYLI CDVYIENSKY 180
  181 LIQEGSAIEK KSAKDTLYIL LDNALKLIHP FMPFISEEMW QRLPKRSTEK AASIVKASYP 240
  241 VYVSEYDDVK SAN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2610.0
Match: 1gaxA_
Description: Valyl-tRNA synthetase (ValRS) C-terminal domain; Valyl-tRNA synthetase (ValRS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ligase activity, forming aminoacyl-tRNA and related compounds 8.24066297904343 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 8.24066297904343 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 8.23006189348918 bayes_pls_golite062009
valine-tRNA ligase activity 7.13767629265822 bayes_pls_golite062009
leucine-tRNA ligase activity 7.03538514482698 bayes_pls_golite062009
ligase activity 6.98979325804867 bayes_pls_golite062009
isoleucine-tRNA ligase activity 6.38633897147986 bayes_pls_golite062009
methionine-tRNA ligase activity 2.56893064485672 bayes_pls_golite062009
catalytic activity 2.26766689929461 bayes_pls_golite062009
tyrosine-tRNA ligase activity 1.88984817882585 bayes_pls_golite062009
arginine-tRNA ligase activity 1.51931993626103 bayes_pls_golite062009
tryptophan-tRNA ligase activity 1.14187887833901 bayes_pls_golite062009
binding 0.987705174689351 bayes_pls_golite062009
cysteine-tRNA ligase activity 0.844943947059557 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.625793556381714 bayes_pls_golite062009
nucleic acid binding 0.514662028202085 bayes_pls_golite062009
nucleotidyltransferase activity 0.2293846471193 bayes_pls_golite062009
protein binding 0.143518788844143 bayes_pls_golite062009
glutamine-tRNA ligase activity 0.118292082006187 bayes_pls_golite062009
RNA binding 0.0208852714448815 bayes_pls_golite062009
mRNA binding 2.82524485163416E-5 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [170-195] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EFTADGKVKP EGVFCIPAPP PNVTGA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [219-357] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KTVLFLPGFD HAGIATQSVV EKQIWAKDRK TRHDYGREAF VGKVWEWKEE YHSRIKNQIQ  60
   61 KLGASYDWSR EAFTLSPELT KSVEEAFVRL HDEGVIYRAS RLVNWSVKLN TAISNLEVEN 120
  121 KDVKSRTLLS VPGYDEKVE

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [505-692] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TIPTCSRSGD IIEPLLKPQW WVSQSEMAKD AIKVVRDGQI TITPKSSEAE YFHWLGNIQD  60
   61 WCISRQLWWG HRCPVYFINI EGEEHDRIDG DYWVAGRSME EAEKKAAAKY PNSKFTLEQD 120
  121 EDVLDTWFSS GLWPFSTLGW PEKTKDMETF YPFSMLETGW DILFFWVTRM ILLGLKLTGS 180
  181 VPFKEVFC

[Run NCBI BLAST on this sequence.]

Region D:
Residues: [946-1104] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AYDLVLNITK EARSLLSEYN ILKNGKVFVE SNHEEYFKTA EDQKDSIVSL IKAIDEVTVV  60
   61 RDASEIPEGC VLQSVNPEVN VHLLVKGHVD IDAEIAKVQK KLEKAKKSKN GIEQTINSKD 120
  121 YETKANTQAK EANKSKLDNT VAEIEGLEAT IENLKRLKL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2610.0
Match: 1gaxA_
Description: Valyl-tRNA synthetase (ValRS) C-terminal domain; Valyl-tRNA synthetase (ValRS)
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [358-504] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FGVLTSFAYP VIGSDEKLII ATTRPETIFG DTAVAVHPDD DRYKHLHGKF IQHPFLPRKI  60
   61 PIITDKEAVD MEFGTGAVKI TPAHDQNDYN TGKRHNLEFI NILTDDGLLN EECGPEWQGM 120
  121 KRFDARKKVI EQLKEKNLYV GQEDNEM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2610.0
Match: 1gaxA_
Description: Valyl-tRNA synthetase (ValRS) C-terminal domain; Valyl-tRNA synthetase (ValRS)
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle