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View Structure Prediction Details

Protein: ERG25
Organism: Saccharomyces cerevisiae
Length: 309 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ERG25.

Description E-value Query
Range		 Subject
Range
gi|190406917 - gi|190406917|gb|EDV10184.1| C-4 sterol methyl oxidase [Saccharomyces cerevisiae RM11-1a]
gi|207345190 - gi|207345190|gb|EDZ72089.1| YGR060Wp-like protein [Saccharomyces cerevisiae AWRI1631]
MSMO_YEAST - Methylsterol monooxygenase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ERG25 PE=1 SV...
ERG25 - C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl grou...
gi|151943340 - gi|151943340|gb|EDN61653.1| C-4 sterol methyl oxidase [Saccharomyces cerevisiae YJM789]
 9.0E-71 [1..309] [1..309]
gi|238879707 - gi|238879707|gb|EEQ43345.1| C-4 methylsterol oxidase [Candida albicans WO-1]
ER25_CANAL, ERG2... - C-4 methylsterol oxidase OS=Candida albicans GN=ERG25 PE=3 SV=1, (O59933) C-4 methyl sterol oxidase ...
MSMO_CANAL - Methylsterol monooxygenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ERG25 PE=3 SV=1
 1.0E-61 [1..306] [4..306]
MSMO_SCHPO - Methylsterol monooxygenase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=erg25 PE=3 SV=1
erg25 - C-4 methylsterol oxidase
 6.0E-60 [9..306] [3..300]
SMO11_ARATH - Methylsterol monooxygenase 1-1 OS=Arabidopsis thaliana GN=SMO1-1 PE=1 SV=1
 2.0E-57 [18..305] [2..290]
gi|123980314, gi... - gi|123995123|gb|ABM85163.1| sterol-C4-methyl oxidase-like [synthetic construct], gi|123980314|gb|ABM...
ENSPTRT00000030805 - null
SC4MOL - sterol-C4-methyl oxidase-like
MSMO1_PONAB - Methylsterol monooxygenase 1 OS=Pongo abelii GN=MSMO1 PE=2 SV=1
ERG25_PONPY - C-4 methylsterol oxidase - Pongo pygmaeus (Orangutan)
 3.0E-57 [8..301] [2..293]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 1.0E-56 [18..309] [2..294]
MSMO1_MOUSE - Methylsterol monooxygenase 1 OS=Mus musculus GN=Msmo1 PE=1 SV=1
 3.0E-56 [8..301] [2..293]
MSMO1_RAT - Methylsterol monooxygenase 1 OS=Rattus norvegicus GN=Msmo1 PE=2 SV=1
 1.0E-54 [8..301] [2..293]

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Predicted Domain #1
Region A:
Residues: [1-309] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAVFNNATL SGLVQASTYS QTLQNVAHYQ PQLNFMEKYW AAWYSYMNND VLATGLMFFL  60
   61 LHEFMYFFRC LPWFIIDQIP YFRRWKLQPT KIPSAKEQLY CLKSVLLSHF LVEAIPIWTF 120
  121 HPMCEKLGIT VEVPFPSLKT MALEIGLFFV LEDTWHYWAH RLFHYGVFYK YIHKQHHRYA 180
  181 APFGLSAEYA HPAETLSLGF GTVGMPILYV MYTGKLHLFT LCVWITLRLF QAVDSHSGYD 240
  241 FPWSLNKIMP FWAGAEHHDL HHHYFIGNYA SSFRWWDYCL DTESGPEAKA SREERMKKRA 300
  301 ENNAQKKTN

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 107.958607
Match: PF01598
Description: Sterol desaturase

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [87-180] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LQPTKIPSAK EQLYCLKSVL LSHFLVEAIP IWTFHPMCEK LGITVEVPFP SLKTMALEIG  60
   61 LFFVLEDTWH YWAHRLFHYG VFYKYIHKQH HRYA

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [181-309] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APFGLSAEYA HPAETLSLGF GTVGMPILYV MYTGKLHLFT LCVWITLRLF QAVDSHSGYD  60
   61 FPWSLNKIMP FWAGAEHHDL HHHYFIGNYA SSFRWWDYCL DTESGPEAKA SREERMKKRA 120
  121 ENNAQKKTN

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.01
Match: 2f5kA
Description: No description for 2f5kA was found.

Predicted functions:

Term Confidence Notes
binding 2.10787756282836 bayes_pls_golite062009
transcription regulator activity 1.56029029012385 bayes_pls_golite062009
chromatin binding 1.51511928418505 bayes_pls_golite062009
transcription repressor activity 0.991756552156335 bayes_pls_golite062009
protein binding 0.759327550978008 bayes_pls_golite062009
nucleic acid binding 0.57519986764207 bayes_pls_golite062009
DNA binding 0.293109488455755 bayes_pls_golite062009
catalytic activity 0.168308115787289 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle