YRC Public Data Repository - Protein Structure Prediction

Protein:	THG1
Organism:	Saccharomyces cerevisiae
Length:	237 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for THG1.

Description	E-value	Query Range	Subject Range
gi\|151943308 - gi\|151943308\|gb\|EDN61621.1\| tRNA-His guanylyltransferase [Saccharomyces cerevisiae YJM789] THG1 - tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription a... THG1_YEAST - tRNA(His) guanylyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=THG1 PE=1 ... gi\|207345214 - gi\|207345214\|gb\|EDZ72105.1\| YGR024Cp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190406949 - gi\|190406949\|gb\|EDV10216.1\| hypothetical protein SCRG_00987 [Saccharomyces cerevisiae RM11-1a]	0.0	[1..237]	[1..237]
THG1_MOUSE - Probable tRNA(His) guanylyltransferase OS=Mus musculus GN=Thg1l PE=1 SV=1	0.0	[1..220]	[30..246]
gi\|8923514, gi\|2... - gi\|8923514\|ref\|NP_060342.1\| interphase cyctoplasmic foci protein 45 [Homo sapiens], gi\|7020726\|dbj\|B...	0.0	[1..220]	[30..246]
SPCC63.07 - tRNA guanylyltransferase THG1_SCHPO - tRNA(His) guanylyltransferase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=thg1 PE=3 SV...	2.0E-91	[1..218]	[1..214]
gi\|7482281 - pir\|\|B69230 conserved hypothetical protein MTH972 - Methanobacterium thermoautotrophicum (strain Del... gi\|15678990, gi\|... - gi\|2622071\|gb\|AAB85468.1\| conserved protein [Methanothermobacter thermautotrophicus str. Delta H], g...	8.0E-61	[20..217]	[19..204]

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Predicted Domain #1

Region A:
Residues: [1-85]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANSKFGYVR QFETHDVILP QCYIVVRIDG KKFHEFSKFY EFAKPNDENA LKLMNACAKN  60
   61 LVLKYKNDII LAFGESDEYS FILKS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [86-237]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STTLFNRRKD KLATLFGSFF TSNYVALWAK FFPEKPLNIK HLPYFDSRCV AYPNLQTIKD  60
   61 YLSWRYVDTH INNLYNTTFW QLIIKCGLTP QESEKKLCGT FSNEKQEILF SECGINYNNE 120
  121 PEMFKKGSLV TRKGEILHIN VIAQIDELFE GY

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.297	0.984	tRNA modification	b.40.4	Nucleic acid-binding proteins

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits