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View Structure Prediction Details

Protein: THG1
Organism: Saccharomyces cerevisiae
Length: 237 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for THG1.

Description E-value Query
Range
Subject
Range
gi|151943308 - gi|151943308|gb|EDN61621.1| tRNA-His guanylyltransferase [Saccharomyces cerevisiae YJM789]
THG1 - tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription a...
THG1_YEAST - tRNA(His) guanylyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=THG1 PE=1 ...
gi|207345214 - gi|207345214|gb|EDZ72105.1| YGR024Cp-like protein [Saccharomyces cerevisiae AWRI1631]
gi|190406949 - gi|190406949|gb|EDV10216.1| hypothetical protein SCRG_00987 [Saccharomyces cerevisiae RM11-1a]
0.0 [1..237] [1..237]
THG1_MOUSE - Probable tRNA(His) guanylyltransferase OS=Mus musculus GN=Thg1l PE=1 SV=1
0.0 [1..220] [30..246]
gi|8923514, gi|2... - gi|8923514|ref|NP_060342.1| interphase cyctoplasmic foci protein 45 [Homo sapiens], gi|7020726|dbj|B...
0.0 [1..220] [30..246]
SPCC63.07 - tRNA guanylyltransferase
THG1_SCHPO - tRNA(His) guanylyltransferase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=thg1 PE=3 SV...
2.0E-91 [1..218] [1..214]
gi|7482281 - pir||B69230 conserved hypothetical protein MTH972 - Methanobacterium thermoautotrophicum (strain Del...
gi|15678990, gi|... - gi|2622071|gb|AAB85468.1| conserved protein [Methanothermobacter thermautotrophicus str. Delta H], g...
8.0E-61 [20..217] [19..204]

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Predicted Domain #1
Region A:
Residues: [1-85]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANSKFGYVR QFETHDVILP QCYIVVRIDG KKFHEFSKFY EFAKPNDENA LKLMNACAKN  60
   61 LVLKYKNDII LAFGESDEYS FILKS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.427 d.58.7 RNA-binding domain, RBD
View Download 0.593 a.4.5 "Winged helix" DNA-binding domain
View Download 0.542 a.4.5 "Winged helix" DNA-binding domain
View Download 0.473 d.68.7 R3H domain
View Download 0.500 a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.454 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.675 d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.627 d.58.49 YajQ-like
View Download 0.461 d.58.2 Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain
View Download 0.479 a.4.5 "Winged helix" DNA-binding domain
View Download 0.445 d.68.3 SirA-like
View Download 0.439 d.58.2 Aspartate carbamoyltransferase, Regulatory-chain, N-terminal domain
View Download 0.431 d.58.5 GlnB-like
View Download 0.410 d.58.49 YajQ-like
View Download 0.403 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.397 d.129.1 TATA-box binding protein-like
View Download 0.376 d.67.2 Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
View Download 0.370 c.78.2 Aspartate/glutamate racemase
View Download 0.368 d.109.1 Actin depolymerizing proteins
View Download 0.367 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.365 a.4.9 Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3
View Download 0.361 d.58.11 EF-G/eEF-2 domains III and V
View Download 0.360 a.2.3 Chaperone J-domain
View Download 0.359 d.95.2 Homing endonucleases
View Download 0.357 a.37.1 A DNA-binding domain in eukaryotic transcription factors
View Download 0.354 c.78.2 Aspartate/glutamate racemase
View Download 0.344 d.74.5 Hypothetical protein Yml108w
View Download 0.343 d.206.1 YggU-like
View Download 0.343 a.61.1 Retroviral matrix proteins
View Download 0.338 a.4.5 "Winged helix" DNA-binding domain
View Download 0.334 d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.334 d.68.4 YhbY-like
View Download 0.333 d.58.14 Ribosomal protein S6
View Download 0.327 d.141.1 Ribosomal protein L6
View Download 0.318 d.13.1 HIT-like
View Download 0.315 d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.307 d.74.1 Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)
View Download 0.290 d.15.7 Immunoglobulin-binding domains
View Download 0.288 a.3.1 Cytochrome c
View Download 0.285 a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.284 a.2.3 Chaperone J-domain
View Download 0.283 a.2.3 Chaperone J-domain
View Download 0.282 a.4.1 Homeodomain-like
View Download 0.282 d.74.1 Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)
View Download 0.277 d.141.1 Ribosomal protein L6
View Download 0.277 a.4.1 Homeodomain-like
View Download 0.269 a.39.1 EF-hand
View Download 0.265 d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.264 d.58.13 Anticodon-binding domain of PheRS
View Download 0.262 d.67.2 Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain
View Download 0.259 a.76.1 Iron-dependent represor protein, dimerization domain
View Download 0.258 a.2.3 Chaperone J-domain
View Download 0.256 a.60.9 lambda integrase-like, N-terminal domain
View Download 0.256 d.74.2 C-terminal domain of arginine repressor
View Download 0.254 a.24.15 FAD-dependent thiol oxidase
View Download 0.254 d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.253 c.95.1 Thiolase-like
View Download 0.253 d.15.7 Immunoglobulin-binding domains
View Download 0.249 d.58.23 Probable ACP-binding domain of malonyl-CoA ACP transacylase
View Download 0.247 d.58.7 RNA-binding domain, RBD
View Download 0.243 d.74.5 Hypothetical protein Yml108w
View Download 0.243 a.181.1 Antibiotic binding domain of TipA-like multidrug resistance regulators
View Download 0.235 a.126.1 Serum albumin-like
View Download 0.235 a.126.1 Serum albumin-like
View Download 0.234 d.206.1 YggU-like
View Download 0.233 c.30.1 PreATP-grasp domain
View Download 0.232 d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.230 a.2.3 Chaperone J-domain
View Download 0.229 a.4.1 Homeodomain-like
View Download 0.224 a.7.6 Ribosomal protein S20
View Download 0.224 d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.221 c.110.1 D-Tyr tRNAtyr deacylase, DTD
View Download 0.219 d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.218 a.24.15 FAD-dependent thiol oxidase
View Download 0.217 a.29.2 Bromodomain
View Download 0.216 a.74.1 Cyclin-like
View Download 0.214 a.151.1 Glutamyl tRNA-reductase dimerization domain
View Download 0.210 a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.209 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.208 c.55.4 Translational machinery components
View Download 0.206 c.78.2 Aspartate/glutamate racemase
View Download 0.206 a.40.1 Calponin-homology domain, CH-domain
View Download 0.204 d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.204 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.203 a.22.1 Histone-fold
View Download 0.202 d.13.1 HIT-like

Predicted Domain #2
Region A:
Residues: [86-237]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 STTLFNRRKD KLATLFGSFF TSNYVALWAK FFPEKPLNIK HLPYFDSRCV AYPNLQTIKD  60
   61 YLSWRYVDTH INNLYNTTFW QLIIKCGLTP QESEKKLCGT FSNEKQEILF SECGINYNNE 120
  121 PEMFKKGSLV TRKGEILHIN VIAQIDELFE GY

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.297 0.984 tRNA modification b.40.4 Nucleic acid-binding proteins
View Download 0.265 0.003 cytoplasm a.1.1 Globin-like
View Download 0.247 0.000 nucleus d.107.1 Ran-binding protein mog1p
View Download 0.266 0.000 tRNA modification a.47.2 t-snare proteins
View Download 0.228 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.217 N/A N/A a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle