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View Structure Prediction Details

Protein: MNT2
Organism: Saccharomyces cerevisiae
Length: 558 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MNT2.

Description E-value Query
Range
Subject
Range
MNT2 - Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans
MNT2_YEAST - Alpha-1,3-mannosyltransferase MNT2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MNT2 ...
0.0 [1..558] [1..558]
gi|1658377 - gi|1658377|gb|AAB18320.1| unknown [Pichia pastoris]
9.0E-56 [137..344] [110..305]

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Predicted Domain #1
Region A:
Residues: [1-129]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRRKNRLFIL VVLLGIVLVV YYSQLNSLDL VEPVQSSSSG NGGCWSYYEG LTPGWLNDFY  60
   61 DVNQITPNPA KDVIELVTRI KIFFNCLQQV DGHNIQRLRD IEKKLFPYIN FEKLETDESA 120
  121 FWHTTTRWN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.346 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.399 c.23.1 CheY-like
View Download 0.504 a.22.1 Histone-fold
View Download 0.444 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.504 a.22.1 Histone-fold
View Download 0.470 a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.470 a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.444 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.399 c.23.1 CheY-like
View Download 0.346 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.314 a.26.1 4-helical cytokines
View Download 0.301 a.79.1 Antitermination factor NusB
View Download 0.295 i.11.1 Computational models partly based on NMR data
View Download 0.261 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.257 a.118.13 Arp2/3 complex 16 kDa subunit ARPC5
View Download 0.231 c.84.1 Phosphoglucomutase, first 3 domains
View Download 0.226 a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.216 f.34.1 Mechanosensitive channel protein MscS (YggB), transmembrane region
View Download 0.210 a.29.2 Bromodomain
View Download 0.206 a.121.1 Tetracyclin repressor-like, C-terminal domain

Predicted Domain #2
Region A:
Residues: [130-305]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GEVYHASMLE FDPKNHQFLR SKPINFDTGL SFWENWLHTV TQSGSKGIVI SASDVQLNET  60
   61 IRLLKVLRFI KNDYPIQIVH NADLSQDSMK SIIKYARSLD TAEYPAQELW FLNVHSLLNP 120
  121 KYSKKFTTYS NKWLALTFSS FEIPILMDSD TVPFVSIEKF YELEEFQKTG VLFFKD

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.75
Match: 1ll0A
Description: Glycogenin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
mannosyltransferase activity 2.72970569728159 bayes_pls_golite062009
transferase activity 2.3313878748424 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 2.31282143022166 bayes_pls_golite062009
catalytic activity 1.73979371332125 bayes_pls_golite062009
transferase activity, transferring hexosyl groups 1.64579615957842 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.58983046450767 bayes_pls_golite062009
UDP-glycosyltransferase activity 1.18238034321908 bayes_pls_golite062009
binding 0.809446708810115 bayes_pls_golite062009
alpha-1,2-mannosyltransferase activity 0.373609073759347 bayes_pls_golite062009
nucleotidyltransferase activity 0.355405833568127 bayes_pls_golite062009
acetylgalactosaminyltransferase activity 0.130891646999536 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [306-558]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RVISDDLFES SELKILREIV YGCIGLDLED ESKIHEQVED PVVAQVLENM FIKKYKHHLE  60
   61 SGLVILHKGK HLFSMLTSIA LQFSPIAEYF HGDKDFFWLG ELLSNNRFTF HPVDASNIGQ 120
  121 LGNVVSKEST GEFYQICSVQ LSHTDRDGSL LWLNGGLNIC KKTSWEYDYE HRQRLNDMFQ 180
  181 NADELREYYA SPVKLEGIII PDTSISGWIN SGECFLFNYC TLFKEGEFGK LIKFKEDEKL 240
  241 RLSQIVDIWN KDI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


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