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View Structure Prediction Details

Protein: MTO1
Organism: Saccharomyces cerevisiae
Length: 679 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MTO1.

Description E-value Query
Range
Subject
Range
MNMG_HAEIN - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Haemophilus influenzae (strain A...
GIDA_HAEIN, MNMG... - tRNA uridine 5-carboxymethylaminomethyl modification enzyme mnmG OS=Haemophilus influenzae GN=mnmG P...
0.0 [34..664] [4..622]
gi|208727143, gi... - gi|208807342|ref|ZP_03249679.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Es...
MNMG_ECO57 - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Escherichia coli O157:H7 GN=mnmG...
gi|12518598, gi|... - gi|15804341|ref|NP_290380.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Esche...
gi|195936368 - gi|195936368|ref|ZP_03081750.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Es...
gi|189373258, gi... - gi|189373258|gb|EDU91674.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Escher...
gi|189358928, gi... - gi|189358928|gb|EDU77347.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Escher...
gi|217326532, gi... - gi|217326532|ref|ZP_03442616.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Es...
gi|15833937, gi|... - gi|15833937|ref|NP_312710.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Esche...
MNMG_ECO5E - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Escherichia coli O157:H7 (strain...
gi|208735700, gi... - gi|208814423|ref|ZP_03255752.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Es...
gi|254595147, gi... - gi|254795747|ref|YP_003080584.1| glucose-inhibited cell-division protein [Escherichia coli O157:H7 s...
gi|209753798, gi... - pir||D86060 glucose-inhibited division protein gidA [similarity] - Escherichia coli (strain O157:H7,...
0.0 [37..664] [7..622]
gi|226838925, gi... - gi|254038960|ref|ZP_04873012.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme mnmG [Es...
MNMG_ECOBW - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Escherichia coli (strain K12 / M...
gi|227883963, gi... - gi|227883963|ref|ZP_04001768.1| glucose inhibited cell division protein A [Escherichia coli 83972], ...
MNMG_ECOLC - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Escherichia coli (strain ATCC 87...
MNMG_ECODH - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Escherichia coli (strain K12 / D...
EG10375 - 5-methylaminomethyl-2-thiouridine modification at tRNA U34 / 5-methylaminomethyl-2-thiouridine modif...
MNMG_ECO24 - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Escherichia coli O139:H28 (strai...
MNMG_ECOSE - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Escherichia coli (strain SE11) G...
MNMG_ECOHS - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Escherichia coli O9:H4 (strain H...
MNMG_ECO8A - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Escherichia coli O8 (strain IAI1...
gi|194428129, gi... - gi|75210649|ref|ZP_00710790.1| COG0445: NAD/FAD-utilizing enzyme apparently involved in cell divisio...
MNMG_ECO81 - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Escherichia coli O81 (strain ED1...
gi|191170517, gi... - gi|75242471|ref|ZP_00726215.1| COG0445: NAD/FAD-utilizing enzyme apparently involved in cell divisio...
MNMG_ECO55 - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Escherichia coli (strain 55989 /...
gi|75258280, gi|... - gi|75258280|ref|ZP_00729728.1| COG0445: NAD/FAD-utilizing enzyme apparently involved in cell divisio...
MNMG_ECO7I - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Escherichia coli O7:K1 (strain I...
gi|188488625, gi... - gi|75514193|ref|ZP_00736501.1| COG0445: NAD/FAD-utilizing enzyme apparently involved in cell divisio...
MNMG_ECOLU - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Escherichia coli O17:K52:H18 (st...
MNMG_SHIBS - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Shigella boydii serotype 4 (stra...
gi|89110266, gi|... - gi|89110266|ref|AP_004046.1| glucose-inhibited cell-division protein [Escherichia coli str. K-12 sub...
GIDA_ECOLI - tRNA uridine 5-carboxymethylaminomethyl modification enzyme gidA (Glucose-inhibited division protein...
EG10375 - 5-methylaminomethyl-2-thiouridine modification at tRNA U34 / 5-methylaminomethyl-2-thiouridine modif...
GIDA_ECOL6, MNMG... - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Escherichia coli O6 GN=mnmG PE=3...
MNMG_ECOL6 - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Escherichia coli O6:H1 (strain C...
gi|124530045, gi... - gi|124530045|ref|ZP_01700828.1| glucose inhibited division protein A [Escherichia coli B], gi|124499...
MNMG_ECOL5 - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Escherichia coli O6:K15:H31 (str...
0.0 [37..664] [7..622]
gi|204322080, gi... - gi|204928647|ref|ZP_03219846.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Sa...
gi|200388594, gi... - gi|200388594|ref|ZP_03215206.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Sa...
gi|238913127 - gi|238913127|ref|ZP_04656964.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Sa...
GIDA_SALTY, MNMG... - tRNA uridine 5-carboxymethylaminomethyl modification enzyme mnmG OS=Salmonella typhimurium GN=mnmG P...
gi|194456753, gi... - gi|194470389|ref|ZP_03076373.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Sa...
MNMG_SALTY - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Salmonella typhimurium (strain L...
MNMG_SALHS - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Salmonella heidelberg (strain SL...
gi|197265255, gi... - gi|197265255|ref|ZP_03165329.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Sa...
MNMG_SALA4 - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Salmonella agona (strain SL483) ...
gi|168464788, gi... - gi|195632101|gb|EDX50585.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Salmon...
gi|168263227, gi... - gi|205348292|gb|EDZ34923.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Salmon...
MNMG_SALNS - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Salmonella newport (strain SL254...
gi|205340555, gi... - gi|205340555|gb|EDZ27319.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Salmon...
gi|167994881, gi... - gi|205327320|gb|EDZ14084.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Salmon...
gi|168245184, gi... - gi|205336051|gb|EDZ22815.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Salmon...
gi|205331678, gi... - gi|205331678|gb|EDZ18442.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Salmon...
MNMG_SALTY - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Salmonella typhimurium GN=mnmG P...
lcl|NC_016856.1_... - [gene=gidA] [protein=tRNA uridine 5-carboxymethylaminomethyl modification protein GidA] [protein_id=...
0.0 [37..664] [7..622]
gi|213649867 - gi|213649867|ref|ZP_03379920.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Sa...
gi|29139576, gi|... - gi|29143940|ref|NP_807282.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Salmo...
gi|16762452 - gi|16762452|ref|NP_458069.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Salmo...
gi|213052661 - gi|213052661|ref|ZP_03345539.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Sa...
gi|213427461 - gi|213427461|ref|ZP_03360211.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Sa...
GIDA_SALTI, MNMG... - tRNA uridine 5-carboxymethylaminomethyl modification enzyme mnmG OS=Salmonella typhi GN=mnmG PE=3 SV...
MNMG_SALTI - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Salmonella typhi GN=mnmG PE=3 SV...
0.0 [37..664] [7..622]
GIDA_PASMU, MNMG... - tRNA uridine 5-carboxymethylaminomethyl modification enzyme mnmG OS=Pasteurella multocida GN=mnmG PE...
MNMG_PASMU - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Pasteurella multocida (strain Pm...
0.0 [34..664] [4..622]
gi|290590, gi|43257 - gi|43257|emb|CAA25773.1| unnamed protein product [Escherichia coli], gi|290590|gb|AAA62093.1| glucos...
0.0 [37..664] [7..621]
gi|229369217, gi... - gi|229606562|ref|YP_002877210.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [V...
gi|229520164, gi... - gi|229520164|ref|ZP_04409591.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Vi...
gi|197751557, gi... - gi|254291137|ref|ZP_04961934.1| glucose inhibited division protein A [Vibrio cholerae AM-19226], gi|...
gi|229346207, gi... - gi|229517144|ref|ZP_04406590.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Vi...
gi|229508288, gi... - gi|229508288|ref|ZP_04397792.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Vi...
MNMG_VIBCH - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Vibrio cholerae serotype O1 (str...
gi|254851566, gi... - gi|75829186|ref|ZP_00758498.1| COG0445: NAD/FAD-utilizing enzyme apparently involved in cell divisio...
MNMG_VIBCM - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Vibrio cholerae serotype O1 (str...
MNMG_VIBC3 - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Vibrio cholerae serotype O1 (str...
gi|153820114, gi... - gi|153820114|ref|ZP_01972781.1| glucose inhibited division protein A [Vibrio cholerae NCTC 8457], gi...
gi|229508640, gi... - gi|229508640|ref|ZP_04398135.1| tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Vi...
MNMG_VIBCH, GIDA... - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Vibrio cholerae GN=mnmG PE=3 SV=...
0.0 [34..664] [4..622]
MNMG_PSEPU - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Pseudomonas putida GN=mnmG PE=3 ...
0.0 [37..664] [7..620]
MNMG_PSEU2 - tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG OS=Pseudomonas syringae pv. syringa...
GIDA_PSESY - (Q9F5X1) Glucose inhibited division protein A
0.0 [37..669] [8..626]

Back

Predicted Domain #1
Region A:
Residues: [1-72]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRVTTLASS CTSFPLQVLR RRLTISSLTS FQPTTKTQVV VIGAGHAGCE AAAASSRTGA  60
   61 HTTLITPSLT DI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
oxidoreductase activity 4.24087829378489 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH 2.84060092432585 bayes_pls_golite062009
catalytic activity 1.56773888754354 bayes_pls_golite062009
antioxidant activity 1.49429830917872 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors 1.39990343076756 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor 1.14701726867934 bayes_pls_golite062009
binding 0.400596507621048 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors 0.36771673037999 bayes_pls_golite062009
dihydrolipoyl dehydrogenase activity 0.187016999137115 bayes_pls_golite062009
protein binding 0.139858531143419 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [73-135]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKCSCNPSIG GVGKGILVKE IDALDGLMGK VTDLAGVQFK MLNRSKGPAV WGPRAQIDRE  60
   61 LYK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [197-270]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSAEIHIGDK RIAAGRIGEQ PTYGISNTLQ NEVGFQLGRL KTGTPARLAK ESIDFSALEV  60
   61 QKGDALPVPM SFLN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.09691
Match: 1ebdA_
Description: Dihydrolipoamide dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [136-196]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KYMQRELSDK KAHPNLSLLQ NKVADLILYD PGCGHKVIKG VVLDDGTQVG ADQVIITTGT  60
   61 F

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.09691
Match: 1ebdA_
Description: Dihydrolipoamide dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [271-331]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ETVSVEPTKQ LDCFGTHTTP QMHDFLRNNL HQSIHIQDTT IKGPRYCPSI EAKILRFPDR  60
   61 S

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [332-437]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SHKIWLEPEG FNSDVIYPNG ISNSMPEDVQ LQMMRLIPGM ANVEILQPAY GVEYDYVDPR  60
   61 QLKPSLETKL VDGLFLAGQI NGTTGYEEAA AQGIIAGINA GLLSRQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.558 0.841 translation c.37.1 P-loop containing nucleoside triphosphate hydrolases

Predicted Domain #6
Region A:
Residues: [438-679]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EREQLVLKRS EAYIGVLIDD LINNGVIEPY RMFTSRSEFR ISVRADNADF RLTPIGAQLG  60
   61 IISPVRLSQY SRDKHLYDET IRALQNFKLS SQKWSSLLQA NIAPQAENRS AWEIFRFKDM 120
  121 DLHKLYECIP DLPINLLDIP MHVVTKINIQ GKYEPYIVKQ NQFVKAFQAD ENMLLPQDYD 180
  181 YRQLPTLSTE CKLLLNRVQP LTIGQARRIQ GITAAALFEL YRVARSQANQ SCKYPLIVSL 240
  241 YM

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle