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View Structure Prediction Details

Protein: SPT16
Organism: Saccharomyces cerevisiae
Length: 1035 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPT16.

Description E-value Query
Range
Subject
Range
SPT16 - Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via intera...
SPT16_YEAST - FACT complex subunit SPT16 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SPT16 PE=1 SV...
0.0 [1..1035] [1..1035]
SUPT16H - suppressor of Ty 16 homolog (S. cerevisiae)
gi|114651875 - gi|114651875|ref|XP_528703.2| PREDICTED: similar to chromatin-specific transcription elongation fact...
gi|208967510 - gi|208967510|dbj|BAG73769.1| suppressor of Ty 16 homolog [synthetic construct]
0.0 [4..1028] [3..1001]
gi|15637171, gi|... - gi|15809048|ref|NP_291096.1| suppressor of Ty 16 homolog [Mus musculus], gi|15637171|gb|AAL04452.1|A...
0.0 [4..1028] [3..1001]
CC68_KLULA, CDC6... - FACT complex subunit SPT16 OS=Kluyveromyces lactis GN=SPT16 PE=3 SV=2, (Q00976) Cell division contro...
SPT16_KLULA - FACT complex subunit SPT16 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1...
0.0 [1..1035] [1..1033]
gi|147903310, gi... - gi|4586287|dbj|BAA76334.1| DUF140 [Xenopus laevis], gi|147903310|ref|NP_001084166.1| DUF140 [Xenopus...
0.0 [4..1035] [3..1010]
spt16 - FACT complex component Spt16
SPT16_SCHPO - FACT complex subunit spt16 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=spt16 PE=1 SV=1
0.0 [1..1035] [1..1011]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [40..975] [7..910]
gi|12082670 - gi|12082670|gb|AAG48574.1|AF253047_2 large subunit Cp complex Cdc68p [Candida albicans]
0.0 [1..1033] [1..1051]
SPT16_ARATH - FACT complex subunit SPT16 OS=Arabidopsis thaliana GN=SPT16 PE=1 SV=1
0.0 [4..1034] [24..1032]

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Predicted Domain #1
Region A:
Residues: [1-171]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEELNIDFDV FKKRIELLYS KYNEFEGSPN SLLFVLGSSN AENPYQKTTI LHNWLLSYEF  60
   61 PATLIALVPG KVIIITSSAK AKHLQKAIDL FKDPESKITL ELWQRNNKEP ELNKKLFDDV 120
  121 IALINSAGKT VGIPEKDSYQ GKFMTEWNPV WEAAVKENEF NVIDISLGLS K

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 80.045757
Match: 1az9__
Description: Aminopeptidase P; Aminopeptidase P, C-terminal domain

Predicted functions:

Term Confidence Notes
transcription regulator activity 2.3228898238998 bayes_pls_golite062009
DNA binding 1.6830709273154 bayes_pls_golite062009
nucleic acid binding 1.67660713848062 bayes_pls_golite062009
binding 1.4562583231987 bayes_pls_golite062009
transcription factor activity 1.02226978078776 bayes_pls_golite062009
protein binding 0.170797254754318 bayes_pls_golite062009
catalytic activity 0.148551873544128 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [172-468]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VWEVKDVNEQ AFLSVSSKGS DKFMDLLSNE MVRAVDEELK ITNAKLSDKI ENKIDDVKFL  60
   61 KQLSPDLSAL CPPNYKFNFD LLDWTYSPII QSGKKFDLRV SARSTNDQLY GNGCILASCG 120
  121 IRYNNYCSNI TRTFLIDPSE EMANNYDFLL TLQKEIVTNI LKPGRTPKEV YESVIEYIEK 180
  181 TKPELVPNFT KNIGSLIGLE FRDSNFILNV KNDYRKIQRG DCFNISFGFN NLKDSQSANN 240
  241 YALQLADTVQ IPLDETEPPR FLTNYTKAKS QISFYFNNEE EDNNKKKSSP ATKVPSK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 80.045757
Match: 1az9__
Description: Aminopeptidase P; Aminopeptidase P, C-terminal domain

Predicted Domain #3
Region A:
Residues: [469-523]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDRNSKILRT KLRGEARGGA EDAQKEQIRK ENQKKLHEKL EKNGLLRFSA ADANG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.651 a.16.1 S15/NS1 RNA-binding domain
View Download 0.589 a.16.1 S15/NS1 RNA-binding domain
View Download 0.554 a.16.1 S15/NS1 RNA-binding domain
View Download 0.477 a.16.1 S15/NS1 RNA-binding domain
View Download 0.445 a.4.1 Homeodomain-like
View Download 0.420 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.418 a.16.1 S15/NS1 RNA-binding domain
View Download 0.417 a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.405 a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.405 a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.369 a.2.10 Epsilon subunit of F1F0-ATP synthase C-terminal domain
View Download 0.367 a.23.5 Hemolysin expression modulating protein HHA
View Download 0.350 a.30.1 ROP protein
View Download 0.322 a.140.1 LEM domain
View Download 0.317 a.112.1 Description not found.
View Download 0.308 a.2.7 tRNA-binding arm
View Download 0.289 f.13.1 Family A G protein-coupled receptor-like
View Download 0.282 a.16.1 S15/NS1 RNA-binding domain
View Download 0.264 a.22.1 Histone-fold
View Download 0.258 a.161.1 beta-catenin-interacting protein ICAT
View Download 0.253 d.50.3 PI-Pfui intein middle domain
View Download 0.236 f.13.1 Family A G protein-coupled receptor-like
View Download 0.234 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.234 a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.221 a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.216 d.96.1 Tetrahydrobiopterin biosynthesis enzymes-like
View Download 0.216 a.2.7 tRNA-binding arm
View Download 0.211 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.209 a.2.2 Ribosomal protein L29 (L29p)
View Download 0.209 a.30.1 ROP protein
View Download 0.205 a.4.1 Homeodomain-like
View Download 0.202 a.2.7 tRNA-binding arm

Predicted Domain #4
Region A:
Residues: [524-773]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PDSEPRQYFK KYESYVRDSQ LPTNIRDLRI HVDWKSQTII LPIYGRPVPF HINSYKNGSK  60
   61 NEEGEYTYLR LNFNSPGSSG GISKKVEELP YEESADNQFV RSITLRSKDG DRMSETFKQI 120
  121 ADLKKEATKR EQERKALADV VQQDKLIENK TGRTKRLDQI FVRPNPDTKR VPSTVFIHEN 180
  181 GIRFQSPLRT DSRIDILFSN IKNLIFQSCK GELIVVIHIH LKNPILMGKK KIQDVQFYRE 240
  241 ASDMSVDETG 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [774-918]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGRRGQSRFR RYGDEDELEQ EQEERRKRAA LDKEFKYFAD AIAEASNGLL TVENTFRDLG  60
   61 FQGVPNRSAV FCMPTTDCLV QLIEPPFLVI NLEEVEICIL ERVQFGLKNF DMVFVYKDFN 120
  121 KPVTHINTVP IESLDFLKQW LTDMD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.600 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.403 a.26.1 4-helical cytokines
View Download 0.460 d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.558 d.110.1 Profilin (actin-binding protein)
View Download 0.429 a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.390 d.218.1 Nucleotidyltransferase
View Download 0.368 d.110.2 GAF domain-like
View Download 0.368 a.39.1 EF-hand
View Download 0.362 a.1.1 Globin-like
View Download 0.362 d.60.1 Probable bacterial effector-binding domain
View Download 0.349 a.60.10 Enzyme I of the PEP:sugar phosphotransferase system HPr-binding (sub)domain
View Download 0.337 a.63.1 Apolipophorin-III
View Download 0.326 b.55.1 PH domain-like
View Download 0.316 a.19.1 Fertilization protein
View Download 0.316 d.80.1 Tautomerase/MIF
View Download 0.307 d.19.1 MHC antigen-recognition domain
View Download 0.302 c.3.1 FAD/NAD(P)-binding domain
View Download 0.287 d.105.1 Clathrin adaptor appendage, alpha and beta chain-specific domain
View Download 0.278 b.1.1 Immunoglobulin
View Download 0.273 f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.242 c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.227 d.105.1 Clathrin adaptor appendage, alpha and beta chain-specific domain
View Download 0.223 d.79.3 L30e-like
View Download 0.222 d.19.1 MHC antigen-recognition domain
View Download 0.206 a.1.1 Globin-like

Predicted Domain #6
Region A:
Residues: [919-1035]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPYTVSTINL NWATIMKSLQ DDPYQFFLDG GWNFLATGSD DEASDESEEE VSEYEASEDD  60
   61 VSDESAFSED EEGSEVDDDI SGDESEDYTG DESEEGEDWD ELEKKAARAD RGANFRD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle