YRC Public Data Repository - Protein Structure Prediction

Protein:	YGL159W
Organism:	Saccharomyces cerevisiae
Length:	370 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YGL159W.

Description	E-value	Query Range	Subject Range
YGL159W - Putative protein of unknown function; deletion mutant has no detectable phenotype YGP9_YEAST - Uncharacterized protein YGL159W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YGL159W ... gi\|151943654 - gi\|151943654\|gb\|EDN61964.1\| conserved protein [Saccharomyces cerevisiae YJM789]	0.0	[1..370]	[1..370]
gi\|50513267, gi\|... - pir\|\|H69457 ornithine cyclodeaminase (arcB) homolog - Archaeoglobus fulgidus, gi\|50513268\|pdb\|1OMO\|B... ALADH_ARCFU - Alanine dehydrogenase OS=Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / N...	2.0E-76	[1..363]	[1..309]
gi\|7482770 - pir\|\|C69066 ornithine cyclodeaminase - Methanobacterium thermoautotrophicum (strain Delta H) gi\|15679492, gi\|... - gi\|2622612\|gb\|AAB85970.1\| ornithine cyclodeaminase [Methanothermobacter thermautotrophicus str. Delt...	3.0E-70	[2..370]	[12..334]
gi\|1066073, gi\|1... - gi\|1588855\|prf\|\|2209368B arginase, gi\|1066073\|gb\|AAC43978.1\| ornithine cyclodeaminase	1.0E-69	[14..361]	[9..317]
CRYM_MACFL - Ketimine reductase mu-crystallin OS=Macropus fuliginosus GN=CRYM PE=2 SV=1 gi\|283930 - gi\|283930\|pir\|\|S27950 ornithine cyclodeaminase-related protein - eastern gray kangaroo	2.0E-69	[6..360]	[8..308]
gi\|10955008, gi\|... - gi\|6498361\|dbj\|BAA87813.1\| tiorf188 [Agrobacterium tumefaciens], gi\|10955008\|ref\|NP_053428.1\| ornith... OCD_AGRFC - Ornithine cyclodeaminase OS=Agrobacterium fabrum (strain C58 / ATCC 33970) GN=arcB PE=3 SV=2	6.0E-69	[14..361]	[9..317]
OCD_BRUME - Ornithine cyclodeaminase OS=Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) GN=... OCD_BRUME - Ornithine cyclodeaminase OS=Brucella melitensis GN=arcB PE=3 SV=1	2.0E-68	[14..370]	[9..325]
OCD_BRUAB - Ornithine cyclodeaminase OS=Brucella abortus biovar 1 (strain 9-941) GN=arcB PE=3 SV=1 OCD_BRUAB - Ornithine cyclodeaminase OS=Brucella abortus GN=arcB PE=3 SV=1	4.0E-68	[14..370]	[9..325]

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Predicted Domain #1

Region A:
Residues: [1-60]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNSIITDDE VREFYLNCSS QTIIESLLSL HESLRLYSQN HEILLNRMFK KLDETNADSN  60
   61

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.828	a.4.5	"Winged helix" DNA-binding domain

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.03099072397093	bayes_pls_golite062009
oxidoreductase activity	0.442294542097958	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [61-283]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISHIFMPVVS KDFSGIKILV NNNNKNFQGV INVIEPETGK LIGCFEAKQI TAIRTALASC  60
   61 IGLYKQLSCS HDKLFRFENG TCYLTCFGTG LQAFWHIYIA IKLIMSGIVG ESLKLVEINI 120
  121 LYHNNMMSLD RLKSLKNLFG SNIKIELNQY QINDISSEGN GAVSNSDIIF GCLPTLEPNL 180
  181 FLRQLLNSKA SVEQKHTYIS LIGSYKPVMH ECDKELIDKF KSD

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.53
Match:	1gpjA
Description:	Glutamyl tRNA-reductase dimerization domain; Glutamyl tRNA-reductase middle domain; Glutamyl tRNA-reductase catalytic, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [284-370]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NESACILVDS REHTLLESGE LIDSNIAPHN LIEIGELDTL KNTVLNLNEK GCKRTITLCK  60
   61 IVGLAVMDVA LAKEFLSLRT KNTENKE

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: