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View Structure Prediction Details

Protein: HUL5
Organism: Saccharomyces cerevisiae
Length: 910 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HUL5.

Description E-value Query
Range
Subject
Range
HUL5_YEAST - Probable E3 ubiquitin-protein ligase HUL5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) G...
gi|207345442 - gi|207345442|gb|EDZ72264.1| YGL141Wp-like protein [Saccharomyces cerevisiae AWRI1631]
HUL5 - Ubiquitin-conjugating enzyme (E4), elongates polyubiquitin chains on substrate proteins; works in op...
0.0 [1..910] [1..910]
oxi-1 - HECT-domain (ubiquitin-transferase). status:Confirmed UniProt:Q9XXE6 protein_id:CAA19508.1
0.0 [288..910] [476..1066]
gi|19718764, gi|... - gi|19718764|ref|NP_570854.1| ubiquitin protein ligase E3A isoform 3 [Homo sapiens], gi|158258465|dbj...
gi|114655961, gi... - gi|114655961|ref|XP_001161311.1| PREDICTED: ubiquitin protein ligase E3A isoform 12 [Pan troglodytes...
0.0 [235..909] [214..871]
UE3A_MOUSE, UBE3... - (O08759) Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein-associated protein E6-AP), Ubi...
0.0 [235..909] [228..884]

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Predicted Domain #1
Region A:
Residues: [1-323]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLNFTGQTRR RNVNLGNRTR NSKKDLLEKA KRERERRAQD KLKEDASKTI QKSIRRHFSN  60
   61 VRLFKNTFTS SQLVHMIPAY GGKLIYYISQ YDLQQLLKLS HNFLSSYPNS LGNRQLLSLL 120
  121 KLYQDDALVA ETLSDLNMDC PTVDEFLDSL SVYLCRASFL SYSSASKLAD VIEAWEVMHS 180
  181 SASISIFSIS IGSYEKRPFA LQFYCILAER NLLPQLINTN PILWDNMAKT YSHCSKGGQK 240
  241 NIAKLLIPNF NNHIAPSVLR SDNDYVLKFY EKAFIDEVIA TTANYVSDED HVKNLMCYIA 300
  301 SSPNQSCKNS VLITLLSNKD FVR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [324-458]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLSWEFFHTK FNASKTEAHP LFSVLAQLID MHLLISTDRE LLDYNSVIPI EELKKFTSTL  60
   61 KDFTFRQYWE LPKSERNPML KEAVPLLSKV YERDSRLHFL STENNPTYWE NSEKQFLNLR 120
  121 FYEELQEYED LYREH

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.872 0.024 protein polyubiquitination a.24.12 Outer surface protein C (OspC)

Predicted Domain #3
Region A:
Residues: [459-549]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LEEESDEDME KEIDLDKERP PLKSLLLNKM KKRLKSSLRF RKLEILLELP FFIPFEERVD  60
   61 LFYMFIALDK KRLSLDDDHN LINMFTPWAS T

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [550-596]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GMRKQSAIIS RDNVLEDAFN AFNSIGERFK ASLDVTFINE FGEEAGI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 504.228787
Match: 1c4zA_
Description: Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [597-695]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGGGITKEFL TTVSDEGFKD PKHELFRTND RYELYPSVVY DATKLKYIWF LGKVVGKCLY  60
   61 EHVLIDVSFA DFFLKKLLNY SNGFLSSFSD LGSYDSVLY

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [752-794]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDYKLNKRCF KPVSAFHGGL SVIIAPHWME MFNSIELQML ISG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 504.228787
Match: 1c4zA_
Description: Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [696-751]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNLIKLLNMT TDEIKSLDLT FEIDEPESSA KVVDLIPNGS KTYVTKDNVL LYVTKV

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [795-910]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ERDNIDLDDL KSNTEYGGYK EEDQTIVDFW EVLNEFKFEE KLNFLKFVTS VPQAPLQGFK  60
   61 ALDPKFGIRN AGTEKYRLPT ASTCVNLLKL PDYRNKTILR EKLLYAINSG ARFDLS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 504.228787
Match: 1c4zA_
Description: Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle