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View Structure Prediction Details

Protein: SRM1
Organism: Saccharomyces cerevisiae
Length: 482 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SRM1.

Description E-value Query
Range		 Subject
Range
RCC1_YEAST - Guanine nucleotide exchange factor SRM1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...
SRM1 - Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic traff...
 0.0 [1..482] [1..482]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [43..482] [47..490]
gi|12001926 - gi|12001926|gb|AAG43106.1|AF049867_1 Prp20p [Candida albicans]
 0.0 [43..470] [47..478]
pim1 - GDP /GTP exchange factor (RanGEF)
RCC1_SCHPO - Protein pim1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pim1 PE=1 SV=2
 7.0E-94 [41..472] [66..478]
gi|15229409 - gi|15229409|ref|NP_188968.1| regulator of chromosome condensation (RCC1) family protein [Arabidopsis...
 7.0E-93 [33..465] [196..592]
HERC3 - hect domain and RLD 3
gi|7657152 - ref|NP_055421.1| hect domain and RLD 3 [Homo sapiens]
gi|187252515, gi... - gi|187252515|gb|AAI66672.1| Hect domain and RLD 3 [synthetic construct], gi|168274306|dbj|BAG09573.1...
 3.0E-92 [48..470] [1..383]
gi|12856817 - gi|12856817|dbj|BAB30794.1| unnamed protein product [Mus musculus]
 8.0E-92 [48..471] [1..384]

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Predicted Domain #1
Region A:
Residues: [1-482] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKRTVATNG DASGAHRAKK MSKTHASHII NAQEDYKHMY LSVQPLDIFC WGTGSMCELG  60
   61 LGPLAKNKEV KRPRLNPFLP RDEAKIISFA VGGMHTLALD EESNVWSWGC NDVGALGRDT 120
  121 SNAKEQLKDM DADDSSDDED GDLNELESTP AKIPRESFPP LAEGHKVVQL AATDNMSCAL 180
  181 FSNGEVYAWG TFRCNEGILG FYQDKIKIQK TPWKVPTFSK YNIVQLAPGK DHILFLDEEG 240
  241 MVFAWGNGQQ NQLGRKVMER FRLKTLDPRP FGLRHVKYIA SGENHCFALT KDNKLVSWGL 300
  301 NQFGQCGVSE DVEDGALVTK PKRLALPDNV VIRSIAAGEH HSLILSQDGD LYSCGRLDMF 360
  361 EVGIPKDNLP EYTYKDVHGK ARAVPLPTKL NNVPKFKSVA AGSHHSVAVA QNGIAYSWGF 420
  421 GETYAVGLGP FEDDTEVPTR IKNTATQDHN IILVGCGGQF SVSGGVKLSD EDAEKRADEM 480
  481 DD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 448.228787
Match: 1a12A_
Description: Regulator of chromosome condensation RCC1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
Ran guanyl-nucleotide exchange factor activity 1.99390987036621 bayes_pls_golite062009
binding 1.94765972306941 bayes_pls_golite062009
protein binding 0.568399753749593 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.290397858094315 bayes_pls_golite062009
GTPase regulator activity 0.284277561587354 bayes_pls_golite062009
catalytic activity 0.261970921089142 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 0.185600765994903 bayes_pls_golite062009
enzyme regulator activity 0.169745277614311 bayes_pls_golite062009
small GTPase regulator activity 0.0831999559001558 bayes_pls_golite062009
Ras guanyl-nucleotide exchange factor activity 0.0619395994301855 bayes_pls_golite062009
ligase activity 0.0362651353144661 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
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