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View Structure Prediction Details

Protein: SPT15
Organism: Saccharomyces cerevisiae
Length: 240 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPT15.

Description E-value Query
Range
Subject
Range
gi|172899 - gi|172899|gb|AAA35146.1| tata-box factor protein
1.0E-89 [1..240] [1..240]
gi|17298078 - gi|17298078|dbj|BAB78513.1| TATA-box binding protein [Lethenteron reissneri]
9.0E-82 [58..239] [118..299]
gi|220942262, gi... - gi|220952470|gb|ACL88778.1| Tbp-PA [synthetic construct], gi|220942262|gb|ACL83674.1| Tbp-PA [synthe...
Tbp-PA - The gene TATA binding protein is referred to in FlyBase by the symbol Dmel\Tbp (CG9874, FBgn0003687)...
3.0E-81 [60..239] [172..351]
TBP_ARTSF - TATA-box-binding protein OS=Artemia franciscana PE=2 SV=1
1.0E-80 [33..239] [73..275]
TBP_SPOFR - TATA-box-binding protein OS=Spodoptera frugiperda GN=Tbp PE=2 SV=1
2.0E-80 [17..239] [85..306]
TBP_BOMMO - TATA-box-binding protein OS=Bombyx mori GN=Tbp PE=2 SV=1
2.0E-79 [17..239] [85..306]
gi|17298076 - gi|17298076|dbj|BAB78512.1| TATA-box binding protein [Oryzias latipes]
2.0E-79 [58..239] [137..318]
gi|447739 - gi|447739|prf||1915304A nylB upstream ORF
3.0E-79 [58..239] [155..336]

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Predicted Domain #1
Region A:
Residues: [1-69]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADEERLKEF KEANKIVFDP NTRQVWENQN RDGTKPATTF QSEEDIKRAA PESEKDTSAT  60
   61 SGIVPTLQN

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [159-240]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIVGSCDVKF PIRLEGLAFS HGTFSSYEPE LFPGLIYRMV KPKIVLLIFV SGKIVLTGAK  60
   61 QREEIYQAFE AIYPVLSEFR KM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1037.616428
Match: 1tbaB_
Description: TATA-box binding protein (TBP), C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 10.1927670598446 bayes_pls_golite062009
RNA polymerase III transcription factor activity 8.4318102330583 bayes_pls_golite062009
transcription regulator activity 4.66773099672992 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.97397050058114 bayes_pls_golite062009
DNA binding 3.68758425895596 bayes_pls_golite062009
nucleic acid binding 3.4119217152884 bayes_pls_golite062009
binding 3.25203283623613 bayes_pls_golite062009
RNA polymerase I transcription factor activity 3.24777019705869 bayes_pls_golite062009
transcription factor activity 2.17821704710246 bayes_pls_golite062009
transcription factor binding 1.86204668268867 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.59579825271822 bayes_pls_golite062009
protein binding 0.938536348073543 bayes_pls_golite062009
transcription coactivator activity 0.312991469396539 bayes_pls_golite062009
transcription activator activity 0.199341831249925 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [70-158]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IVATVTLGCR LDLKTVALHA RNAEYNPKRF AAVIMRIREP KTTALIFASG KMVVTGAKSE  60
   61 DDSKLASRKY ARIIQKIGFA AKFTDFKIQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1037.616428
Match: 1tbaB_
Description: TATA-box binding protein (TBP), C-terminal domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle