| Protein: | MET6 |
| Organism: | Saccharomyces cerevisiae |
| Length: | 767 amino acids |
| Reference: | Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MET6.
| Description | E-value | Query Range |
Subject Range |
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0.0 | [2..767] | [1..763] |
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0.0 | [2..767] | [1..763] |
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0.0 | [2..767] | [1..763] |
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0.0 | [1..767] | [1..767] |
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0.0 | [2..767] | [1..763] |
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0.0 | [2..767] | [21..782] |
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Region A: Residues: [1-104] |
1 11 21 31 41 51
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1 MVQSAVLGFP RIGPNRELKK ATEGYWNGKI TVDELFKVGK DLRTQNWKLQ KEAGVDIIPS 60
61 NDFSFYDQVL DLSLLFNVIP DRYTKYDLSP IDTLFAMGRG LQRK
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| Detection Method: |  |
Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.
| MCM Score |
GO Score |
GO Term |
SCOP Match |
SCOP Description | ||
| View | Download | 0.658 | 0.071 | methionine biosynthetic process | a.133.1 | Phospholipase A2, PLA2 |
| View | Download | 0.550 | 0.021 | methionine biosynthetic process | a.100.1 | 6-phosphogluconate dehydrogenase C-terminal domain-like |
| View | Download | 0.563 | 0.008 | methionine biosynthetic process | a.24.9 | alpha-catenin/vinculin |
| View | Download | 0.528 | 0.006 | methionine biosynthetic process | a.24.4 | Hemerythrin |
| View | Download | 0.492 | 0.003 | methionine biosynthetic process | a.59.1 | PAH2 domain |
| View | Download | 0.488 | N/A | N/A | a.24.3 | Cytochromes |
| View | Download | 0.477 | N/A | N/A | a.47.2 | t-snare proteins |
| View | Download | 0.464 | N/A | N/A | a.52.1 | Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin |
| View | Download | 0.459 | N/A | N/A | a.3.1 | Cytochrome c |
| View | Download | 0.398 | N/A | N/A | f.34.1 | Mechanosensitive channel protein MscS (YggB), transmembrane region |
| View | Download | 0.389 | N/A | N/A | a.71.2 | Helical domain of Sec23/24 |
| View | Download | 0.386 | N/A | N/A | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.377 | N/A | N/A | a.24.9 | alpha-catenin/vinculin |
| View | Download | 0.367 | N/A | N/A | f.1.4 | Bcl-2 inhibitors of programmed cell death |
| View | Download | 0.365 | N/A | N/A | a.121.1 | Tetracyclin repressor-like, C-terminal domain |
| View | Download | 0.355 | N/A | N/A | a.24.17 | Group V grass pollen allergen |
| View | Download | 0.347 | N/A | N/A | a.71.2 | Helical domain of Sec23/24 |
| View | Download | 0.346 | N/A | N/A | a.4.9 | Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 |
| View | Download | 0.341 | N/A | N/A | f.18.1 | F1F0 ATP synthase subunit A |
| View | Download | 0.341 | N/A | N/A | a.64.1 | Saposin |
| View | Download | 0.328 | N/A | N/A | a.4.5 | "Winged helix" DNA-binding domain |
| View | Download | 0.323 | N/A | N/A | a.24.16 | Nucleotidyltransferase substrate binding subunit/domain |
| View | Download | 0.320 | N/A | N/A | a.54.1 | Domain of early E2A DNA-binding protein, ADDBP |
| View | Download | 0.316 | N/A | N/A | a.7.3 | Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain |
| View | Download | 0.310 | N/A | N/A | a.151.1 | Glutamyl tRNA-reductase dimerization domain |
| View | Download | 0.298 | N/A | N/A | a.90.1 | Transcription factor STAT-4 N-domain |
| View | Download | 0.298 | N/A | N/A | a.29.2 | Bromodomain |
| View | Download | 0.296 | N/A | N/A | a.7.6 | Ribosomal protein S20 |
| View | Download | 0.290 | N/A | N/A | a.29.2 | Bromodomain |
| View | Download | 0.280 | N/A | N/A | a.118.1 | ARM repeat |
| View | Download | 0.277 | N/A | N/A | a.80.1 | DNA polymerase III clamp loader subunits, C-terminal domain |
| View | Download | 0.271 | N/A | N/A | a.63.1 | Apolipophorin-III |
| View | Download | 0.268 | N/A | N/A | a.24.7 | FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP) |
| View | Download | 0.265 | N/A | N/A | a.100.1 | 6-phosphogluconate dehydrogenase C-terminal domain-like |
| View | Download | 0.264 | N/A | N/A | a.25.1 | Ferritin-like |
| View | Download | 0.263 | N/A | N/A | a.29.3 | Acyl-CoA dehydrogenase C-terminal domain-like |
| View | Download | 0.262 | N/A | N/A | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.261 | N/A | N/A | a.3.1 | Cytochrome c |
| View | Download | 0.257 | N/A | N/A | f.36.1 | Neurotransmitter-gated ion-channel pransmembrane pore |
| View | Download | 0.255 | N/A | N/A | a.24.13 | Domain of the SRP/SRP receptor G-proteins |
| View | Download | 0.254 | N/A | N/A | a.24.3 | Cytochromes |
| View | Download | 0.251 | N/A | N/A | d.14.1 | Ribosomal protein S5 domain 2-like |
| View | Download | 0.250 | N/A | N/A | d.192.1 | YlxR-like |
| View | Download | 0.249 | N/A | N/A | a.118.8 | TPR-like |
| View | Download | 0.246 | N/A | N/A | d.163.1 | DNA breaking-rejoining enzymes |
| View | Download | 0.244 | N/A | N/A | a.45.1 | Glutathione S-transferase (GST), C-terminal domain |
| View | Download | 0.243 | N/A | N/A | a.39.1 | EF-hand |
| View | Download | 0.242 | N/A | N/A | a.24.17 | Group V grass pollen allergen |
| View | Download | 0.239 | N/A | N/A | d.58.21 | Molybdenum cofactor biosynthesis protein C, MoaC |
| View | Download | 0.234 | N/A | N/A | a.2.7 | tRNA-binding arm |
| View | Download | 0.233 | N/A | N/A | d.6.1 | Prion-like |
| View | Download | 0.226 | N/A | N/A | a.46.1 | Methionine synthase domain |
| View | Download | 0.224 | N/A | N/A | i.1.1 | Ribosome and ribosomal fragments |
| View | Download | 0.216 | N/A | N/A | a.39.1 | EF-hand |
| View | Download | 0.214 | N/A | N/A | a.2.3 | Chaperone J-domain |
| View | Download | 0.207 | N/A | N/A | a.26.1 | 4-helical cytokines |
| View | Download | 0.205 | N/A | N/A | a.27.1 | Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases |
| View | Download | 0.203 | N/A | N/A | a.7.2 | Enzyme IIa from lactose specific PTS, IIa-lac |
| View | Download | 0.202 | N/A | N/A | a.39.1 | EF-hand |
| View | Download | 0.201 | N/A | N/A | a.28.3 | Retrovirus capsid protein C-terminal domain |
| Term | Confidence | Notes |
| 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity | 6.40786073037099 | bayes_pls_golite062009 |
| 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity | 6.40786073037099 | bayes_pls_golite062009 |
| uroporphyrinogen decarboxylase activity | 3.13638443707338 | bayes_pls_golite062009 |
| S-methyltransferase activity | 3.0142199413027 | bayes_pls_golite062009 |
| catalytic activity | 2.37862248560593 | bayes_pls_golite062009 |
| binding | 1.590130518929 | bayes_pls_golite062009 |
| carbon-carbon lyase activity | 1.54242506764415 | bayes_pls_golite062009 |
| carboxy-lyase activity | 1.52150758949987 | bayes_pls_golite062009 |
| lyase activity | 0.825209465219608 | bayes_pls_golite062009 |
| protein binding | 0.21865699924356 | bayes_pls_golite062009 |
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Region A: Residues: [105-401] |
1 11 21 31 41 51
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1 ATETEKAVDV TALEMVKWFD SNYHYVRPTF SKTTQFKLNG QKPVDEFLEA KELGIHTRPV 60
61 LLGPVSYLFL GKADKDSLDL EPLSLLEQLL PLYTEILSKL ASAGATEVQI DEPVLVLDLP 120
121 ANAQAAIKKA YTYFGEQSNL PKITLATYFG TVVPNLDAIK GLPVAALHVD FVRAPEQFDE 180
181 VVAAIGNKQT LSVGIVDGRN IWKNDFKKSS AIVNKAIEKL GADRVVVATS SSLLHTPVDL 240
241 NNETKLDAEI KGFFSFATQK LDEVVVITKN VSGQDVAAAL EANAKSVESR GKSKFIH
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| Detection Method: | |
Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.
Found no structure predictions for this domain.
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Region A: Residues: [402-440] |
1 11 21 31 41 51
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1 DAAVKARVAS IDEKMSTRAA PFEQRLPEQQ KVFNLPLFP
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Region B: Residues: [674-767] |
1 11 21 31 41 51
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1 VSIEFSKKDD ANYIAEFKNY PNHIGLGLFD IHSPRIPSKD EFIAKISTIL KSYPAEKFWV 60
61 NPDCGLKTRG WEETRLSLTH MVEAAKYFRE QYKN
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| Detection Method: | |
| Confidence: | 11.96 |
| Match: | 1j93A |
| Description: | Uroporphyrinogen decarboxylase, UROD |
Matching Structure (courtesy of the PDB): |
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Region A: Residues: [441-673] |
1 11 21 31 41 51
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1 TTTIGSFPQT KDIRINRNKF NKGTISAEEY EKFINSEIEK VIRFQEEIGL DVLVHGEPER 60
61 NDMVQYFGEQ INGYAFTVNG WVQSYGSRYV RPPIIVGDLS RPKAMSVKES VYAQSITSKP 120
121 VKGMLTGPIT CLRWSFPRDD VDQKTQAMQL ALALRDEVND LEAAGIKVIQ VDEPALREGL 180
181 PLREGTERSA YYTWAAEAFR VATSGVANKT QIHSHFCYSD LDPNHIKALD ADV
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| Detection Method: | |
| Confidence: | 11.96 |
| Match: | 1j93A |
| Description: | Uroporphyrinogen decarboxylase, UROD |
| Matching Structure (courtesy of the PDB): |
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