YRC Public Data Repository - Protein Structure Prediction

Protein:	PTC2
Organism:	Saccharomyces cerevisiae
Length:	464 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PTC2.

Description	E-value	Query Range	Subject Range
PTC2 - Type 2C protein phosphatase; dephosphorylates Hog1p to limit maximal osmostress induced kinase activ... gi\|151944806 - gi\|151944806\|gb\|EDN63065.1\| protein phosphatase type 2C [Saccharomyces cerevisiae YJM789] gi\|190405653 - gi\|190405653\|gb\|EDV08920.1\| protein phosphatase type 2C [Saccharomyces cerevisiae RM11-1a] PP2C2_YEAST - Protein phosphatase 2C homolog 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PTC2 PE...	0.0	[1..464]	[1..464]
PPM1A_RABIT - Protein phosphatase 1A OS=Oryctolagus cuniculus GN=PPM1A PE=2 SV=1	1.0E-91	[1..342]	[1..330]
CCDS9744.1_1 - null PPM1A - protein phosphatase, Mg2+/Mn2+ dependent, 1A gi\|114653343, gi... - gi\|114653347\|ref\|XP_509986.2\| PREDICTED: hypothetical protein LOC452950 isoform 9 [Pan troglodytes],... gi\|109083826, gi... - gi\|109083828\|ref\|XP_001096358.1\| PREDICTED: similar to protein phosphatase 1A isoform 1 isoform 5 [M... gi\|123996549, gi... - gi\|168279063\|dbj\|BAG11411.1\| protein phosphatase 1A [synthetic construct], gi\|123996549\|gb\|ABM85876....	3.0E-91	[1..342]	[1..330]
PPM1A_RAT - Protein phosphatase 1A OS=Rattus norvegicus GN=Ppm1a PE=1 SV=1	3.0E-91	[1..342]	[1..330]
PPM1A_BOVIN - Protein phosphatase 1A OS=Bos taurus GN=PPM1A PE=2 SV=1	5.0E-91	[1..342]	[1..330]
PP2C2_SCHPO - Protein phosphatase 2C homolog 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ptc2 PE=3... ptc2 - protein phosphatase 2C Ptc2	5.0E-91	[1..322]	[1..324]
PPM1A_MOUSE - Protein phosphatase 1A OS=Mus musculus GN=Ppm1a PE=1 SV=1	3.0E-90	[1..342]	[1..330]

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Predicted Domain #1

Region A:
Residues: [1-376]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGQILSNPVI DKESHSGADS LTAFGLCAMQ GWRMSMEDSH ILEPNVLTKS DKDHIAFYGI  60
   61 FDGHGGAKVA EYCGNKIVEI LQEQKSFHEG NLPRALIDTF INTDVKLLQD PVMKEDHSGC 120
  121 TATSILVSKS QNLLVCGNAG DSRTVLATDG NAKALSYDHK PTLASEKSRI VAADGFVEMD 180
  181 RVNGNLALSR AIGDFEFKSN PKLGPEEQIV TCVPDILEHS LDYDRDEFVI LACDGIWDCL 240
  241 TSQDCVDLVH LGLREGKTLN EISSRIIDVC CAPTTEGTGI GCDNMSIVVV ALLKEGEDVA 300
  301 QWSDRMKSKA HRTSVRSFAD KRRRVFSYYD FSKCNDEQVF AITTKKPQDK FTRDHEAAVA 360
  361 SVTAADNDDP MDIDDT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	517.383689
Match:	1a6q__
Description:	Protein serine/threonine phosphatase 2C, C-terminal domain; Protein serine/threonine phosphatase 2C, catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoprotein phosphatase activity	7.29765002420868	bayes_pls_golite062009
phosphatase activity	6.84540130415879	bayes_pls_golite062009
phosphoric ester hydrolase activity	6.63839066304808	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	5.76293366458633	bayes_pls_golite062009
protein serine/threonine phosphatase activity	5.66354576593165	bayes_pls_golite062009
hydrolase activity	2.5631136269171	bayes_pls_golite062009
binding	1.74689317666387	bayes_pls_golite062009
catalytic activity	1.53401212718168	bayes_pls_golite062009
protein binding	1.47578617076714	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [377-464]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DADTDAENLD PSSQSKSKTS GPIDLASLEA LLGATGGVKT DSNGNKVTYT LPQSALAQLL  60
   61 QTMGHDPASS HPENDSNTDH KAGRSHLQ

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: