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View Structure Prediction Details

Protein: YER064C
Organism: Saccharomyces cerevisiae
Length: 505 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YER064C.

Description E-value Query
Range
Subject
Range
VHR2_YEAST - Transcription factor VHR2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VHR2 PE=1 SV=1
YER064C - Non-essential nuclear protein; null mutation has global effects on transcription
gi|151944779 - gi|151944779|gb|EDN63038.1| conserved protein [Saccharomyces cerevisiae YJM789]
0.0 [1..505] [1..505]
gi|11120027 - gi|11120027|gb|AAG30815.1| unknown [Saccharomyces pastorianus]
gi|11120027|gb|A... - unknown [Saccharomyces pastorianus]
0.0 [80..505] [1..421]

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Predicted Domain #1
Region A:
Residues: [1-211]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIDDTENSKI HLEGSHKTGK YTGYGTTHKI RAQLNFNDEK KWKKFSSRRL ELIDSFGLSQ  60
   61 HKASEQDDNI RQIATILRSE FEYPDTFSAE FEKLVTAAVQ SVRRNRKRSK KKLLDSKKKI 120
  121 ARGKVQKIPL SPPSSSNMGS CSASNASSSD EEASVKEEPA EHALPSLNTI TSQKLLPYPN 180
  181 GRTLPPVPTQ VRSLLKKNAS LLRDPSAPYA H

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [212-444]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGDEKLQKFD IEDQPLESEQ EYDFIAKSII VEIVNNAIPL PEQIQRDKFI RPNLTKKKGC  60
   61 QSKVVISNNL RKLILSKIHN SRTCLEMSKD ERNLDSFANL ETLGKNSLMA SISLVVENSF 120
  121 SHLPSSTKQY LTERLSSIEF LTILSQRLFM PATRQLFADL SQEKIQVRVL NLILGSLVKD 180
  181 YGFDASLAPI NEIIYHMTLH QYPLVCSNKQ SNPMRPHSTS EVLSAHSSTK DAS

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 7.57
Match: 1jfzA
Description: RNase III endonuclease catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 3.56857846292068 bayes_pls_golite062009
binding 3.16671084167938 bayes_pls_golite062009
DNA binding 2.46976707655498 bayes_pls_golite062009
transcription regulator activity 2.36798074064997 bayes_pls_golite062009
RNA binding 1.64815102811033 bayes_pls_golite062009
protein binding 1.33798788677218 bayes_pls_golite062009
structural constituent of ribosome 1.28842676742386 bayes_pls_golite062009
transcription factor activity 1.27008996745235 bayes_pls_golite062009
structural molecule activity 1.15978347169403 bayes_pls_golite062009
double-stranded RNA binding 0.402046758389082 bayes_pls_golite062009
transcription activator activity 0.389298959802427 bayes_pls_golite062009
transcription repressor activity 0.134687687018266 bayes_pls_golite062009
catalytic activity 0.00430305721638241 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [445-505]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPGKEEPRVT RSSTSADSTI ITLPSIEVPN TYDDDRLKML SAISLQIENS TFSKPFSTIS  60
   61 K

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle