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View Structure Prediction Details

Protein: HOM3
Organism: Saccharomyces cerevisiae
Length: 527 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HOM3.

Description E-value Query
Range
Subject
Range
HOM3 - Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in ...
AK_YEAST - Aspartokinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HOM3 PE=1 SV=2
0.0 [1..527] [1..527]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [7..523] [82..577]
AKH1_MAIZE - Bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic OS=Zea mays GN=AKHSDH1 PE=2 SV=...
0.0 [7..523] [89..581]
AKH_DAUCA - Bifunctional aspartokinase/homoserine dehydrogenase, chloroplastic (Fragment) OS=Daucus carota PE=1 ...
0.0 [7..523] [87..582]
AKH1_ARATH - Bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic OS=Arabidopsis thaliana GN=AKHS...
0.0 [7..523] [79..572]

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Predicted Domain #1
Region A:
Residues: [1-339]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPMDFQPTSS HSNWVVQKFG GTSVGKFPVQ IVDDIVKHYS KPDGPNNNVA VVCSARSSYT  60
   61 KAEGTTSRLL KCCDLASQES EFQDIIEVIR QDHIDNADRF ILNPALQAKL VDDTNKELEL 120
  121 VKKYLNASKV LGEVSSRTVD LVMSCGEKLS CLFMTALCND RGCKAKYVDL SHIVPSDFSA 180
  181 SALDNSFYTF LVQALKEKLA PFVSAKERIV PVFTGFFGLV PTGLLNGVGR GYTDLCAALI 240
  241 AVAVNADELQ VWKEVDGIFT ADPRKVPEAR LLDSVTPEEA SELTYYGSEV IHPFTMEQVI 300
  301 RAKIPIRIKN VQNPLGNGTI IYPDNVAKKG ESTPPHPPE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.39794
Match: 1gs5A_
Description: N-acetyl-l-glutamate kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
acetolactate synthase activity 3.48670706716817 bayes_pls_golite062009
aspartate kinase activity 3.23731032633773 bayes_pls_golite062009
transferase activity 3.047646907595 bayes_pls_golite062009
catalytic activity 2.83338756483354 bayes_pls_golite062009
kinase activity 2.6815187488202 bayes_pls_golite062009
phosphotransferase activity, carboxyl group as acceptor 2.65970393362911 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.63366715780289 bayes_pls_golite062009
amino acid kinase activity 2.38310367076654 bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups 2.27460110663386 bayes_pls_golite062009
acetylglutamate kinase activity 1.28891782911186 bayes_pls_golite062009
glutamate 5-kinase activity 0.416864856459166 bayes_pls_golite062009
binding 0.416787048641206 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [340-527]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLSSSFYEKR KRGATAITTK NDIFVINIHS NKKTLSHGFL AQIFTILDKY KLVVDLISTS  60
   61 EVHVSMALPI PDADSLKSLR QAEEKLRILG SVDITKKLSI VSLVGKHMKQ YIGIAGTMFT 120
  121 TLAEEGINIE MISQGANEIN ISCVINESDS IKALQCIHAK LLSERTNTSN QFEHAIDERL 180
  181 EQLKRLGI

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle