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View Structure Prediction Details

Protein: PMI40
Organism: Saccharomyces cerevisiae
Length: 429 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PMI40.

Description E-value Query
Range		 Subject
Range
PMI40 - Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; requir...
gi|190405563 - gi|190405563|gb|EDV08830.1| mannose-6-phosphate isomerase [Saccharomyces cerevisiae RM11-1a]
MPI_YEAST - Mannose-6-phosphate isomerase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PMI40 PE=1...
 0.0 [1..429] [1..429]
MANA_CANAL, MPI_... - Mannose-6-phosphate isomerase OS=Candida albicans GN=PMI1 PE=1 SV=2, Mannose-6-phosphate isomerase -...
MPI_CANAL - Mannose-6-phosphate isomerase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PMI1 PE=1 SV=2
gi|238883822 - gi|238883822|gb|EEQ47460.1| mannose-6-phosphate isomerase [Candida albicans WO-1]
 0.0 [2..427] [3..440]
MPI - mannose phosphate isomerase
 0.0 [3..426] [4..421]
MPI_MOUSE - Mannose-6-phosphate isomerase OS=Mus musculus GN=Mpi PE=1 SV=1
 0.0 [2..426] [3..421]
MPI2_ARATH - Mannose-6-phosphate isomerase 2 OS=Arabidopsis thaliana GN=PMI2 PE=1 SV=1
 0.0 [3..426] [20..433]
gi|11275529, gi|... - gi|34895502|ref|NP_909094.1| putative mannose-6-phosphate isomerase [Oryza sativa (japonica cultivar...
 0.0 [2..426] [14..422]
MANA_EMENI - Mannose-6-phosphate isomerase (EC 5.3.1.8) (Phosphomannose isomerase) (PMI) (Phosphohexomutase) - Em...
 0.0 [1..427] [1..450]

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Predicted Domain #1
Region A:
Residues: [1-429] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNKLFRLDA GYQQYDWGKI GSSSAVAQFA AHSDPSVQIE QDKPYAELWM GTHSKMPSYN  60
   61 HESKESLRDI ISKNPSAMLG KDIIDKFHAT NELPFLFKVL SIEKVLSIQA HPDKALGKIL 120
  121 HAQDPKNYPD DNHKPEMAIA VTDFEGFCGF KPLQEIADEL KRIPELRNIV GEETSRNFIE 180
  181 NIQPSAQKGS PEDEQNKKLL QAVFSRVMNA SDDKIKIQAR SLVERSKNSP SDFNKPDLPE 240
  241 LIQRLNKQFP DDVGLFCGCL LLNHCRLNAG EAIFLRAKDP HAYISGDIME CMAASDNVVR 300
  301 AGFTPKFKDV KNLVSMLTYT YDPVEKQKMQ PLKFDRSSGN GKSVLYNPPI EEFAVLETTF 360
  361 DEKLGQRHFE GVDGPSILIT TKGNGYIKAD GQKLKAEPGF VFFIAPHLPV DLEAEDEAFT 420
  421 TYRAFVEPN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1682.0
Match: 1pmi__
Description: Phosphomannose isomerase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 1.86690435826277 bayes_pls_golite062009
nucleic acid binding 1.64913898350018 bayes_pls_golite062009
DNA binding 1.57178406956273 bayes_pls_golite062009
binding 1.54596514444405 bayes_pls_golite062009
transcription factor activity 0.937392765385803 bayes_pls_golite062009
intramolecular oxidoreductase activity 0.8581504516071 bayes_pls_golite062009
catalytic activity 0.401988496917198 bayes_pls_golite062009
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 0.353173877157675 bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting aldoses and ketoses 0.348782780143283 bayes_pls_golite062009
protein binding 0.110960530780648 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
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