YRC Public Data Repository - Protein Structure Prediction

Protein:	DSF1, YNR073C
Organism:	Saccharomyces cerevisiae
Length:	502 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DSF1, YNR073C.

Description	E-value	Query Range	Subject Range
DSF1, YNR073C - Deletion suppressor of mpt5 mutation, Putative mannitol dehydrogenase YN073_YEAST, DSF... - Mannitol dehydrogenase YNR073C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YNR073C P... gi\|190405499 - gi\|190405499\|gb\|EDV08766.1\| hypothetical protein SCRG_04402 [Saccharomyces cerevisiae RM11-1a] gi\|207346139 - gi\|207346139\|gb\|EDZ72727.1\| YEL070Wp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|151944601 - gi\|151944601\|gb\|EDN62879.1\| conserved protein [Saccharomyces cerevisiae YJM789]	0.0	[1..502]	[1..502]
gi\|218771909, gi... - gi\|218891683\|ref\|YP_002440550.1\| mannitol dehydrogenase [Pseudomonas aeruginosa LESB58], gi\|21877190... gi\|11350582 - pir\|\|D83353 mannitol dehydrogenase PA2342 [imported] - Pseudomonas aeruginosa (strain PAO1) gi\|9948378, gi\|1... - gi\|9948378\|gb\|AAG05730.1\|AE004660_6 mannitol dehydrogenase [Pseudomonas aeruginosa PAO1], gi\|1559753... gi\|84320918, gi\|... - gi\|84320918\|ref\|ZP_00969285.1\| COG0246: Mannitol-1-phosphate/altronate dehydrogenases [Pseudomonas a... gi\|107101786 - gi\|107101786\|ref\|ZP_01365704.1\| hypothetical protein PaerPA_01002831 [Pseudomonas aeruginosa PACS2]	0.0	[11..501]	[2..491]
gi\|209399925, gi... - gi\|209399925\|ref\|YP_002270542.1\| mannitol dehydrogenase family protein [Escherichia coli O157:H7 str... gi\|208821912, gi... - gi\|208821912\|ref\|ZP_03262232.1\| mannitol dehydrogenase family protein [Escherichia coli O157:H7 str.... gi\|254793089, gi... - gi\|254793089\|ref\|YP_003077926.1\| predicted mannonate dehydrogenase [Escherichia coli O157:H7 str. TW... gi\|208732951, gi... - gi\|208816303\|ref\|ZP_03257482.1\| mannitol dehydrogenase family protein [Escherichia coli O157:H7 str.... gi\|195937036 - gi\|195937036\|ref\|ZP_03082418.1\| putative oxidoreductase [Escherichia coli O157:H7 str. EC4024] gi\|217329103, gi... - gi\|217329103\|ref\|ZP_03445183.1\| mannitol dehydrogenase family protein [Escherichia coli O157:H7 str.... gi\|189368113, gi... - gi\|189368113\|gb\|EDU86529.1\| mannitol dehydrogenase family protein [Escherichia coli O157:H7 str. EC4... gi\|189354528, gi... - gi\|189354528\|gb\|EDU72947.1\| mannitol dehydrogenase family protein [Escherichia coli O157:H7 str. EC4... gi\|168751795, gi... - gi\|188014226\|gb\|EDU52348.1\| mannitol dehydrogenase family protein [Escherichia coli O157:H7 str. EC4... gi\|15831405, gi\|... - gi\|15831405\|ref\|NP_310178.1\| putative oxidoreductase [Escherichia coli O157:H7 str. Sakai], gi\|13361... gi\|189370073, gi... - gi\|189370073\|gb\|EDU88489.1\| mannitol dehydrogenase family protein [Escherichia coli O157:H7 str. EC8... gi\|189000885, gi... - gi\|189000885\|gb\|EDU69871.1\| mannitol dehydrogenase family protein [Escherichia coli O157:H7 str. EC4... gi\|187770135, gi... - gi\|187770135\|gb\|EDU33979.1\| mannitol dehydrogenase family protein [Escherichia coli O157:H7 str. EC4... gi\|189361881, gi... - gi\|189361881\|gb\|EDU80300.1\| mannitol dehydrogenase family protein [Escherichia coli O157:H7 str. EC4... gi\|15831405, gi\|... - gi\|15831405\|ref\|NP_310178.1\| putative oxidoreductase [Escherichia coli O157:H7], gi\|13361617\|dbj\|BAB... gi\|209770128, gi... - pir\|\|G90897 probable oxidoreductase ECs2151 [imported] - Escherichia coli (strain O157:H7, substrain...	0.0	[20..498]	[6..483]
gi\|189357881, gi... - gi\|189357881\|gb\|EDU76300.1\| fructuronate reductase [Escherichia coli O157:H7 str. EC4401], gi\|168754... gi\|168749520, gi... - gi\|188016196\|gb\|EDU54318.1\| fructuronate reductase [Escherichia coli O157:H7 str. EC4113], gi\|168749... gi\|189364289, gi... - gi\|189364289\|gb\|EDU82708.1\| fructuronate reductase [Escherichia coli O157:H7 str. EC4486], gi\|168766... gi\|189368891, gi... - gi\|189368891\|gb\|EDU87307.1\| fructuronate reductase [Escherichia coli O157:H7 str. EC4501], gi\|168760... gi\|168781607, gi... - gi\|189000792\|gb\|EDU69778.1\| fructuronate reductase [Escherichia coli O157:H7 str. EC4076], gi\|168781... gi\|168773971, gi... - gi\|187770267\|gb\|EDU34111.1\| fructuronate reductase [Escherichia coli O157:H7 str. EC4196], gi\|168773... gi\|254595725, gi... - gi\|254796325\|ref\|YP_003081162.1\| D-mannonate oxidoreductase, NAD-binding [Escherichia coli O157:H7 s... gi\|209749274, gi... - pir\|\|E86130 mannonate oxidoreductase [imported] - Escherichia coli (strain O157:H7, substrain EDL93... gi\|15804898, gi\|... - gi\|15804898\|ref\|NP_290939.1\| mannonate oxidoreductase [Escherichia coli O157:H7 EDL933], gi\|12519333... gi\|13364760, gi\|... - gi\|15834536\|ref\|NP_313309.1\| D-mannonate oxidoreductase [Escherichia coli O157:H7], gi\|13364760\|dbj\|... gi\|194423261, gi... - gi\|83586652\|ref\|ZP_00925284.1\| COG0246: Mannitol-1-phosphate/altronate dehydrogenases [Escherichia c... gi\|168797890, gi... - gi\|189379523\|gb\|EDU97939.1\| fructuronate reductase [Escherichia coli O157:H7 str. EC508], gi\|1687978... gi\|194415383, gi... - gi\|75212115\|ref\|ZP_00712155.1\| COG0246: Mannitol-1-phosphate/altronate dehydrogenases [Escherichia c... gi\|189374780, gi... - gi\|189374780\|gb\|EDU93196.1\| fructuronate reductase [Escherichia coli O157:H7 str. EC869], gi\|1687849... gi\|208806843, gi... - gi\|208806843\|ref\|ZP_03249180.1\| fructuronate reductase [Escherichia coli O157:H7 str. EC4206], gi\|20... gi\|195937332 - gi\|195937332\|ref\|ZP_03082714.1\| D-mannonate oxidoreductase [Escherichia coli O157:H7 str. EC4024] gi\|208820100, gi... - gi\|208820100\|ref\|ZP_03260420.1\| fructuronate reductase [Escherichia coli O157:H7 str. EC4042], gi\|20... gi\|208733743, gi... - gi\|208812466\|ref\|ZP_03253795.1\| fructuronate reductase [Escherichia coli O157:H7 str. EC4045], gi\|20... gi\|75229721, gi\|... - gi\|75229721\|ref\|ZP_00716254.1\| COG0246: Mannitol-1-phosphate/altronate dehydrogenases [Escherichia c... gi\|13364760, gi\|... - gi\|15834536\|ref\|NP_313309.1\| D-mannonate oxidoreductase [Escherichia coli O157:H7 str. Sakai], gi\|13... gi\|217325964, gi... - gi\|217325964\|ref\|ZP_03442048.1\| fructuronate reductase [Escherichia coli O157:H7 str. TW14588], gi\|2... gi\|73858247, gi\|... - gi\|74314770\|ref\|YP_313189.1\| D-mannonate oxidoreductase [Shigella sonnei Ss046], gi\|73858247\|gb\|AAZ9... gi\|209399476, gi... - gi\|209399476\|ref\|YP_002273848.1\| fructuronate reductase [Escherichia coli O157:H7 str. EC4115], gi\|2...	0.0	[24..498]	[11..486]
gi\|89111035, gi\|... - gi\|89111035\|ref\|AP_004815.1\| D-mannonate oxidoreductase, NAD-binding [Escherichia coli str. K-12 sub... EG20248 - D-mannonate oxidoreductase, NAD-dependent / D-mannonate oxidoreductase, NAD-dependent; glucuronate b... UXUB_ECOLI - D-mannonate oxidoreductase (EC 1.1.1.57) (Fructuronate reductase) - Escherichia coli EG20248 - D-mannonate oxidoreductase, NAD-dependent / D-mannonate oxidoreductase, NAD-dependent; glucuronate b... gi\|218707991, gi... - gi\|218707991\|ref\|YP_002415510.1\| D-mannonate oxidoreductase, NAD-binding [Escherichia coli UMN026], ... gi\|238860808, gi... - gi\|238903416\|ref\|YP_002929212.1\| D-mannonate oxidoreductase, NAD-binding [Escherichia coli BW2952], ...	0.0	[24..498]	[11..486]
gi\|205327665, gi... - gi\|205327665\|gb\|EDZ14429.1\| D-mannonate oxidoreductase [Salmonella enterica subsp. enterica serovar ... gi\|16420028, gi\|... - gi\|16764853\|ref\|NP_460468.1\| putative mannitol dehydrogenase [Salmonella typhimurium LT2], gi\|164200... lcl\|NC_016856.1_... - [gene=ydfI] [protein=putative mannitol dehydrogenase] [protein_id=YP_005237390.1] [location=1596047....	0.0	[8..502]	[1..487]

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Predicted Domain #1

Region A:
Residues: [1-296]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKSDETTAT SLNAKTLKSF ESTLPIPTYP REGVKQGIVH LGVGAFHRSH LAVFMHRLMQ  60
   61 EHHLKDWSIC GVGLMKADAL MRDAMKAQDC LYTLVERGIK DTNAYIVGSI TAYMYAPDDP 120
  121 RAVIEKMANP DTHIVSLTVT ENGYYHSEAT NSLMTDAPEI INDLNHPEKP DTLYGYLYEA 180
  181 LLLRYKRGLT PFTIMSCDNM PQNGVTVKTM LVAFAKLKKD EKFAAWIEDK VTSPNSMVDR 240
  241 VTPRCTDKER KYVADTWGIK DQCPVVAEPF IQWVLEDNFS DGRPPWELVG VQVVKD

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	87.443697
Match:	PF01232
Description:	Mannitol dehydrogenase Rossmann domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.79741889688267	bayes_pls_golite062009
oxidoreductase activity	1.69771604880532	bayes_pls_golite062009
phosphogluconate dehydrogenase (decarboxylating) activity	0.882672090231461	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	0.418775403210681	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	0.32207755075663	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	0.138709569969554	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [297-502]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VDSYELMKLR LLNGGHSAMG YLGYLAGYTY IHEVVNDPTI NKYIRVLMRE EVIPLLPKVP  60
   61 GVDFEEYTAS VLERFSNPAI QDTVARICLM GSGKMPKYVL PSIYEQLRKP DGKYKLLAVC 120
  121 VAGWFRYLTG VDMNGKPFEI EDPMAPTLKA AAVKGGKDPH ELLNIEVLFS PEIRDNKEFV 180
  181 AQLTHSLETV YDKGPIAAIK EILDQV

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.92
Match:	1n1bA
Description:	(+)-bornyl diphosphate synthase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: