YRC Public Data Repository - Protein Structure Prediction

Protein:	GLY1
Organism:	Saccharomyces cerevisiae
Length:	387 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GLY1.

Description	E-value	Query Range	Subject Range
gi\|453570, gi\|585212 - gi\|585212\|sp\|P37303.1\|GLY1_YEAST RecName: Full=Low specificity L-threonine aldolase; Short=Low speci...	2.0E-82	[1..387]	[1..387]
GLYA_AQUAE - Serine hydroxymethyltransferase OS=Aquifex aeolicus (strain VF5) GN=glyA PE=3 SV=1 GLYA_AQUAE - Serine hydroxymethyltransferase OS=Aquifex aeolicus GN=glyA PE=3 SV=1	2.0E-78	[6..383]	[17..414]
gi\|25286203 - pir\|\|H97501 serine hydroxymethyltransferase (serine methylase) (shmt) [imported] - Agrobacterium tum... gi\|15888503, gi\|... - gi\|15888503\|ref\|NP_354184.1\| serine hydroxymethyltransferase [Agrobacterium tumefaciens str. C58], g...	4.0E-77	[5..387]	[86..490]
GLY1_ASHGO - Threonine aldolase OS=Ashbya gossypii GN=GLY1 PE=3 SV=2 GLY1_ASHGO - Low-specificity L-threonine aldolase OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 ...	7.0E-77	[4..387]	[5..382]
GLYA_THEMA - Pyridoxal-phosphate-dependent serine hydroxymethyltransferase OS=Thermotoga maritima GN=glyA PE=3 SV... GLYA_THEMA - Serine hydroxymethyltransferase OS=Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10...	2.0E-76	[7..386]	[19..419]
NFS1_CANAL - Cysteine desulfurase, mitochondrial OS=Candida albicans GN=NFS1 PE=3 SV=1 NFS1_CANAL - Cysteine desulfurase, mitochondrial OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=NFS1 PE=2...	3.0E-76	[12..370]	[86..484]
GLYA1_RHIME - Serine hydroxymethyltransferase 1 OS=Rhizobium meliloti (strain 1021) GN=glyA1 PE=3 SV=1 GLYA1_RHIME, GLA... - Serine hydroxymethyltransferase 1 OS=Rhizobium meliloti GN=glyA1 PE=3 SV=1, (Q92QU6) Serine hydroxym...	1.0E-75	[5..387]	[26..430]

Back

Predicted Domain #1

Region A:
Residues: [1-19]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEFELPPKY ITAANDLRS

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [269-387]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SHSLAHELAE YCEAKGIPLE SPADTNFVFI NLKAARMDPD VLVKKGLKYN VKLMGGRVSF  60
   61 HYQVTRDTLE KVKLAISEAF DYAKEHPFDC NGPTQIYRSE STEVDVDGNA IREIKTYKY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	524.39794
Match:	1jg8A_
Description:	Low-specificity threonine aldolase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
glycine dehydrogenase (decarboxylating) activity	2.63753310919108	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	2.63753310919108	bayes_pls_golite062009
transferase activity	2.59075614411581	bayes_pls_golite062009
threonine aldolase activity	2.36742457876142	bayes_pls_golite062009
catalytic activity	2.29878871754893	bayes_pls_golite062009
L-aspartate:2-oxoglutarate aminotransferase activity	1.87460342369605	bayes_pls_golite062009
transcription regulator activity	1.67701710033155	bayes_pls_golite062009
DNA binding	1.4774443071095	bayes_pls_golite062009
nucleic acid binding	1.39741122443159	bayes_pls_golite062009
transferase activity, transferring nitrogenous groups	1.28316822767388	bayes_pls_golite062009
transaminase activity	1.24990480711889	bayes_pls_golite062009
transcription factor activity	1.15775909410582	bayes_pls_golite062009
binding	1.09053123792737	bayes_pls_golite062009
O-phospho-L-serine:2-oxoglutarate aminotransferase activity	0.994935084630764	bayes_pls_golite062009
methyltransferase activity	0.681623261233707	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	0.60304280865376	bayes_pls_golite062009
glycine C-acetyltransferase activity	0.367632398200112	bayes_pls_golite062009
structural molecule activity	0.347975812448725	bayes_pls_golite062009
glycine hydroxymethyltransferase activity	0.271623203801431	bayes_pls_golite062009
pyridoxal phosphate binding	0.16957228630576	bayes_pls_golite062009
vitamin B6 binding	0.16957228630576	bayes_pls_golite062009
L-allo-threonine aldolase activity	0.140152839681041	bayes_pls_golite062009
carbon-carbon lyase activity	0.11598778799668	bayes_pls_golite062009
4-aminobutyrate transaminase activity	0.0779403509221881	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [20-268]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTFTTPTAEM MEAALEASIG DAVYGEDVDT VRLEQTVARM AGKEAGLFCV SGTLSNQIAI  60
   61 RTHLMQPPYS ILCDYRAHVY THEAAGLAIL SQAMVVPVVP SNGDYLTLED IKSHYVPDDG 120
  121 DIHGAPTRLI SLENTLHGIV YPLEELVRIK AWCMENGLKL HCDGARIWNA AAQSGVPLKQ 180
  181 YGEIFDSISI CLSKSMGAPI GSVLVGNLKF VKKATHFRKQ QGGGIRQSGM MARMALVNIN 240
  241 NDWKSQLLY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	524.39794
Match:	1jg8A_
Description:	Low-specificity threonine aldolase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: