YRC Public Data Repository - Protein Structure Prediction

Protein:	URA3
Organism:	Saccharomyces cerevisiae
Length:	267 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for URA3.

Description	E-value	Query Range	Subject Range
PYRF_CANMA - Orotidine 5'-phosphate decarboxylase OS=Candida maltosa GN=URA3 PE=3 SV=1	0.0	[1..265]	[2..266]
PYRF_CANTR - Orotidine 5'-phosphate decarboxylase OS=Candida tropicalis GN=URA3 PE=3 SV=1	0.0	[1..265]	[2..266]
PYRF_CYBJA - Orotidine 5'-phosphate decarboxylase OS=Cyberlindnera jadinii GN=URA3 PE=3 SV=1	5.0E-99	[1..266]	[2..266]
PYRF_CANDC - Orotidine 5'-phosphate decarboxylase OS=Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 ... PYRF_CANDU - Orotidine 5'-phosphate decarboxylase OS=Candida dubliniensis GN=URA3 PE=3 SV=1	2.0E-98	[1..265]	[3..269]
PYRF_CANGA - Orotidine 5'-phosphate decarboxylase OS=Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NB... PYRF_CANGA - Orotidine 5'-phosphate decarboxylase OS=Candida glabrata GN=URA3 PE=3 SV=1	2.0E-98	[1..264]	[1..264]
gi\|223364524 - gi\|223364524\|gb\|ACM86779.1\| orotidine-5'-phosphate decarboxylase [Cloning vector pEG(KT)] gi\|223364529 - gi\|223364529\|gb\|ACM86783.1\| orotidine-5'-phosphate decarboxylase [Cloning vector pEG(KG)] PYRF_YEAST - Orotidine 5'-phosphate decarboxylase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=URA... gi\|193246600 - gi\|193246600\|gb\|ACF17168.1\| URA3 [Yeast selection vector pIS419] URA3 - Orotidine-5'-phosphate (OMP) decarboxylase, catalyzes the sixth enzymatic step in the de novo biosyn... gi\|193246603 - gi\|193246603\|gb\|ACF17170.1\| URA3 [Yeast selection vector pIS420] gi\|193246606 - gi\|193246606\|gb\|ACF17172.1\| URA3 [Yeast selection vector pIS421] gi\|193246609 - gi\|193246609\|gb\|ACF17174.1\| URA3 [Yeast selection vector pIS438] gi\|193246597 - gi\|193246597\|gb\|ACF17166.1\| URA3 [Yeast selection vector pIS418] gi\|1335934, gi\|1... - gi\|1335939\|gb\|AAB01174.1\| OMP decarboxylase [synthetic construct], gi\|1335934\|gb\|AAB01170.1\| OMP dec... gi\|23506936 - gi\|23506936\|gb\|AAN31952.1\| orotidine-5'-phosphate decarboxylase; Ura3p [Cloning vector YDp-U] gi\|94963138 - gi\|94963138\|gb\|ABF48727.1\| URA3 [HIS3/URA3 reporter vector pH3U3] gi\|151944688 - gi\|151944688\|gb\|EDN62947.1\| orotidine-5'-phosphate decarboxylase [Saccharomyces cerevisiae YJM789]	3.0E-98	[1..267]	[1..267]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	3.0E-98	[1..267]	[1..267]
gi\|156254840 - gi\|156254840\|gb\|ABU62832.1\| orotidine-5'-monophosphate decarboxylase [Expression vector pPZ3TA] PYRF_CANAL - Orotidine 5'-phosphate decarboxylase OS=Candida albicans GN=URA3 PE=3 SV=3 PYRF_CANAL - Orotidine 5'-phosphate decarboxylase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=URA3 PE=...	3.0E-98	[1..265]	[3..269]
gi\|447739 - gi\|447739\|prf\|\|1915304A nylB upstream ORF	1.0E-97	[1..267]	[1..267]

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Predicted Domain #1

Region A:
Residues: [1-267]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKATYKERA ATHPSPVAAK LFNIMHEKQT NLCASLDVRT TKELLELVEA LGPKICLLKT  60
   61 HVDILTDFSM EGTVKPLKAL SAKYNFLLFE DRKFADIGNT VKLQYSAGVY RIAEWADITN 120
  121 AHGVVGPGIV SGLKQAAEEV TKEPRGLLML AELSCKGSLA TGEYTKGTVD IAKSDKDFVI 180
  181 GFIAQRDMGG RDEGYDWLIM TPGVGLDDKG DALGQQYRTV DDVVSTGSDI IIVGRGLFAK 240
  241 GRDAKVEGER YRKAGWEAYL RRCGQQN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1607.522879
Match:	1dqwA_
Description:	Orotidine 5'-monophosphate decarboxylase (OMP decarboxylase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
orotidine-5'-phosphate decarboxylase activity	2.87717797280068	bayes_pls_golite062009
catalytic activity	2.44231061702877	bayes_pls_golite062009
binding	1.26628194990205	bayes_pls_golite062009
ribulose-phosphate 3-epimerase activity	0.982517927791965	bayes_pls_golite062009
carboxy-lyase activity	0.83446736141993	bayes_pls_golite062009
indole-3-glycerol-phosphate synthase activity	0.700596444201789	bayes_pls_golite062009
phosphoribosylanthranilate isomerase activity	0.644387926981014	bayes_pls_golite062009
tryptophan synthase activity	0.580372404365274	bayes_pls_golite062009
carbon-carbon lyase activity	0.54291459543716	bayes_pls_golite062009
orotate phosphoribosyltransferase activity	0.108467338662618	bayes_pls_golite062009
protein binding	0.014429239696785	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: