YRC Public Data Repository - Protein Structure Prediction

Protein:	APA2
Organism:	Saccharomyces cerevisiae
Length:	325 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for APA2.

Description	E-value	Query Range	Subject Range
APA2_YEAST - Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 2 OS=Saccharomyces cerevisiae (strain ATCC 20... gi\|190404553 - gi\|190404553\|gb\|EDV07820.1\| 5',5'-P-1,P-4-tetraphosphate phosphorylase II [Saccharomyces cerevisiae ... gi\|151942491 - gi\|151942491\|gb\|EDN60847.1\| 5',5'''-P-1,P-4-tetraphosphate phosphorylase II [Saccharomyces cerevisia... APA2 - Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolis...	0.0	[1..325]	[1..325]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[2..325]	[3..321]
APA2_KLULA - 5',5'''-P-1,P-4-tetraphosphate phosphorylase 2 OS=Kluyveromyces lactis GN=APA2 PE=3 SV=1 APA2_KLULA - Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 2 OS=Kluyveromyces lactis (strain ATCC 8585 /...	0.0	[1..325]	[1..331]
gi\|17133602, gi\|... - gi\|17231958\|ref\|NP_488506.1\| Ap4A phosphorylase II [Nostoc sp. PCC 7120], gi\|17133602\|dbj\|BAB76165.1... gi\|25530194 - pir\|\|AB2364 Ap4A phosphorylase II [imported] - Nostoc sp. (strain PCC 7120)	1.0E-81	[3..298]	[12..289]
gi\|7469381 - pir\|\|S75978 hypothetical protein - Synechocystis sp. (strain PCC 6803) gi\|16332026, gi\|... - gi\|16332026\|ref\|NP_442754.1\| AP-4-A phosphorylase II [Synechocystis sp. PCC 6803], gi\|1001338\|dbj\|BA...	3.0E-57	[1..289]	[24..279]

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Predicted Domain #1

Region A:
Residues: [1-325]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIEENLKQKI HDKFVAAKKN GHLKVTHAES KKLKDPQTTT QYWVTFAPSL ALKPDANKNS  60
   61 DSKAEDPFAN PDEELVVTED LNGDGEYKLL LNKFPVVPEH SLLVTSEFKD QRSALTPSDL 120
  121 MTAYNVLCSL QGDKDDDVTC ERYLVFYNCG PHSGSSQDHK HLQIMQMPEK FIPFQDVLCN 180
  181 GKDHFLPTFN AEPLQDDKVS FAHFVLPLPE SSDQVDEDLL AMCYVSLMQR ALTFFQDWTN 240
  241 ESPELTKSYN VLLTKKWICV VPRSHAKSGP PLMLNINSTG YCGMILVKDR EKLENLTEDP 300
  301 HLVDKSLLQC GFPNTAGQKP TEYHY

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	13.35
Match:	1gupA
Description:	Galactose-1-phosphate uridylyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nucleic acid binding	1.74990165024183	bayes_pls_golite062009
binding	1.71599870633602	bayes_pls_golite062009
hydrolase activity	0.690968602046843	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.342529552808262	bayes_pls_golite062009
protein binding	0.315946879872005	bayes_pls_golite062009
catalytic activity	0.096119422680995	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: