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View Structure Prediction Details

Protein: SAM2
Organism: Saccharomyces cerevisiae
Length: 384 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SAM2.

Description E-value Query
Range		 Subject
Range
METK1_CATRO - S-adenosylmethionine synthase 1 OS=Catharanthus roseus GN=SAMS1 PE=1 SV=1
 0.0 [5..384] [2..388]
METK3_ORYSJ - S-adenosylmethionine synthase 3 OS=Oryza sativa subsp. japonica GN=METK3 PE=2 SV=1
 0.0 [1..384] [1..391]
METK_DENCR - S-adenosylmethionine synthase OS=Dendrobium crumenatum GN=SAMS PE=2 SV=1
 0.0 [1..384] [1..390]
METK_PHALU - S-adenosylmethionine synthase OS=Phaseolus lunatus GN=SAMS PE=2 SV=1
 0.0 [4..384] [2..389]
METK1_ORYSJ - S-adenosylmethionine synthase 1 OS=Oryza sativa subsp. japonica GN=SAM1 PE=2 SV=1
METK1_ORYSI - S-adenosylmethionine synthase 1 OS=Oryza sativa subsp. indica GN=SAM1 PE=2 SV=2
METK_ORYSA - S-adenosylmethionine synthetase 1 (EC 2.5.1.6) (Methionine adenosyltransferase 1) (AdoMet synthetase...
 0.0 [1..384] [1..391]
METK2_SOLLC - S-adenosylmethionine synthase 2 OS=Solanum lycopersicum GN=SAM2 PE=2 SV=1
 0.0 [5..384] [2..388]
gi|17529621 - gi|17529621|emb|CAC82203.1| S-adenosylmethionine synthetase [Oryza sativa (indica cultivar-group)]
 0.0 [1..384] [1..391]
METK_MESCR - S-adenosylmethionine synthase OS=Mesembryanthemum crystallinum GN=METK PE=2 SV=1
 0.0 [5..384] [2..387]
METK1_ELAUM - S-adenosylmethionine synthase 1 OS=Elaeagnus umbellata GN=SAMS1 PE=2 SV=1
 0.0 [5..384] [2..388]

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Predicted Domain #1
Region A:
Residues: [1-16] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKSKTFLFT SESVGE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [132-241] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TDETPEGLPL TILLAHKLNM AMADARRDGS LPWLRPDTKT QVTVEYEDDN GRWVPKRIDT  60
   61 VVISAQHADE ISTADLRTQL QKDIVEKVIP KDMLDENTKY FIQPSGRFVI

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [253-277] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKIIVDAYGG ASSVGGGAFS GKDYS

[Run NCBI BLAST on this sequence.]

Region D:
Residues: [355-373] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LARPIYLPTA SYGHFTNQE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2570.0
Match: 1qm4A_
Description: S-adenosylmethionine synthetase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
methionine adenosyltransferase activity 8.00759843092519 bayes_pls_golite062009
transferase activity 1.78879119839291 bayes_pls_golite062009
binding 1.70779292877479 bayes_pls_golite062009
catalytic activity 1.59111295908728 bayes_pls_golite062009
transferase activity, transferring alkyl or aryl (other than methyl) groups 1.11999094477144 bayes_pls_golite062009
protein binding 0.298204436433395 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [17-110] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GHPDKICDQV SDAILDACLE QDPFSKVACE TAAKTGMIMV FGEITTKARL DYQQIVRDTI  60
   61 KKIGYDDSAK GFDYKTCNVL VAIEQQSPDI AQGL

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [242-252] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGPQGDAGLT G

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2570.0
Match: 1qm4A_
Description: S-adenosylmethionine synthetase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [111-131] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HYEKSLEDLG AGDQGIMFGY A

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [278-354] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVDRSAAYAA RWVAKSLVAA GLCKRVQVQF SYAIGIAEPL SLHVDTYGTA TKSDDEIIEI  60
   61 IKKNFDLRPG VLVKELD

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [374-384] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YSWEKPKKLE F

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 2570.0
Match: 1qm4A_
Description: S-adenosylmethionine synthetase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle