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View Structure Prediction Details

Protein: TIF35
Organism: Saccharomyces cerevisiae
Length: 274 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TIF35.

Description E-value Query
Range		 Subject
Range
PABP1_MOUSE - Polyadenylate-binding protein 1 OS=Mus musculus GN=Pabpc1 PE=1 SV=2
 5.0E-69 [1..273] [38..271]
PABP1_BOVIN - Polyadenylate-binding protein 1 OS=Bos taurus GN=PABPC1 PE=2 SV=1
gi|109087089 - gi|109087089|ref|XP_001098239.1| PREDICTED: poly(A) binding protein, cytoplasmic 1 isoform 2 [Macaca...
gi|123993665, gi... - gi|168278070|dbj|BAG11013.1| polyadenylate-binding protein 1 [synthetic construct], gi|123999981|gb|...
gi|194036975 - gi|194036975|ref|XP_001927782.1| PREDICTED: similar to Polyadenylate-binding protein 1 (Poly(A)-bind...
PABPC1 - poly(A) binding protein, cytoplasmic 1
gi|73974130, gi|... - gi|73974178|ref|XP_857695.1| PREDICTED: similar to Polyadenylate-binding protein 1 (Poly(A)-binding ...
 6.0E-69 [1..273] [38..271]
PABP1_RAT - Polyadenylate-binding protein 1 OS=Rattus norvegicus GN=Pabpc1 PE=1 SV=1
 7.0E-69 [1..273] [38..271]
gi|2665654 - gi|2665654|gb|AAB88449.1| polyadenylate binding protein [Petromyzon marinus]
 3.0E-67 [1..273] [38..272]
gi|19526272 - gi|19526272|gb|AAL89666.1|AF411956_7 polyA-binding protein [Takifugu rubripes]
 4.0E-67 [1..273] [38..271]
gi|13540314 - gi|13540314|gb|AAK29408.1|AF338225_1 embryonic poly(A) binding protein [Xenopus laevis]
 4.0E-66 [1..273] [38..271]

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Predicted Domain #1
Region A:
Residues: [1-64] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEVAPEEII ENADGSRSII TYKIEDGVKY KITQKVKEVK VLEKVHKSVA ERKNWHKYGS  60
   61 EKGS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.443 0.916 translation initiation factor activity b.34.5 Translation proteins SH3-like domain
View Download 0.444 0.916 translation initiation factor activity d.19.1 MHC antigen-recognition domain
View Download 0.580 0.916 translation initiation factor activity b.84.2 Rudiment single hybrid motif
View Download 0.523 0.916 translation initiation factor activity b.114.1 N-utilization substance G protein NusG, insert domain
View Download 0.565 0.916 translation initiation factor activity g.28.1 Thyroglobulin type-1 domain
View Download 0.429 0.916 translation initiation factor activity d.9.1 Interleukin 8-like chemokines
View Download 0.399 0.916 translation initiation factor activity d.50.1 dsRNA-binding domain-like
View Download 0.394 0.916 translation initiation factor activity d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.393 0.916 translation initiation factor activity d.9.1 Interleukin 8-like chemokines
View Download 0.385 0.916 translation initiation factor activity g.18.1 Complement control module/SCR domain
View Download 0.383 0.916 translation initiation factor activity d.19.1 MHC antigen-recognition domain
View Download 0.380 0.916 translation initiation factor activity b.71.1 Glycosyl hydrolase domain
View Download 0.340 0.916 translation initiation factor activity d.19.1 MHC antigen-recognition domain
View Download 0.337 0.916 translation initiation factor activity d.15.7 Immunoglobulin-binding domains
View Download 0.333 0.916 translation initiation factor activity b.101.1 Ribonuclease domain of colicin E3
View Download 0.331 0.916 translation initiation factor activity d.49.1 Signal recognition particle alu RNA binding heterodimer, SRP9/14
View Download 0.324 0.916 translation initiation factor activity b.38.2 YhbC-like, C-terminal domain
View Download 0.319 0.916 translation initiation factor activity g.24.1 TNF receptor-like
View Download 0.300 0.916 translation initiation factor activity d.186.1 Head-to-tail joining protein W, gpW
View Download 0.293 0.916 translation initiation factor activity b.5.1 alpha-Amylase inhibitor tendamistat
View Download 0.266 0.916 translation initiation factor activity b.40.6 MOP-like
View Download 0.240 0.916 translation initiation factor activity b.38.1 Sm-like ribonucleoproteins
View Download 0.239 0.916 translation initiation factor activity b.55.1 PH domain-like
View Download 0.217 0.916 translation initiation factor activity c.55.7 Methylated DNA-protein cysteine methyltransferase domain
View Download 0.216 0.916 translation initiation factor activity b.61.4 Quinohemoprotein amine dehydrogenase A chain, domain 3
View Download 0.216 0.916 translation initiation factor activity b.61.3 D-aminopeptidase, middle and C-terminal domains
View Download 0.204 0.916 translation initiation factor activity b.1.2 Fibronectin type III
View Download 0.203 0.916 translation initiation factor activity g.27.1 Fibronectin type I module
View Download 0.203 0.916 translation initiation factor activity b.59.1 XRCC4, N-terminal domain
View Download 0.201 0.916 translation initiation factor activity d.28.1 Ribosomal protein S19

Predicted functions:

Term Confidence Notes
mRNA binding 4.52007814408702 bayes_pls_golite062009
nucleic acid binding 4.51665560478175 bayes_pls_golite062009
RNA binding 4.50438526063124 bayes_pls_golite062009
binding 3.64400841800969 bayes_pls_golite062009
translation initiation factor activity 3.27900316559423 bayes_pls_golite062009
structural molecule activity 2.78501986457503 bayes_pls_golite062009
transcription regulator activity 1.7776932219095 bayes_pls_golite062009
DNA binding 1.65208390030564 bayes_pls_golite062009
1.49431666307335 bayes_pls_golite062009
protein binding 1.12215421354121 bayes_pls_golite062009
single-stranded RNA binding 0.90573796517364 bayes_pls_golite062009
RNA cap binding 0.847034036194541 bayes_pls_golite062009
mRNA 3'-UTR binding 0.824614388276642 bayes_pls_golite062009
transcription factor activity 0.795084003256395 bayes_pls_golite062009
translation regulator activity 0.38120065819101 bayes_pls_golite062009
poly-pyrimidine tract binding 0.32812362201346 bayes_pls_golite062009
sequence-specific DNA binding 0.304235325881492 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.128616879457381 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [65-183] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAGPSAVTAR LGEEVELRLS RNWKQAEEER IQKEKASLTK TGLQCRLCGN DHMTMNCPFK  60
   61 TILSELSALE DPATNEGGVE AASEEKAGQV GGAGSIPGQY VPPSRRAGAR DPSSDAYRD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 78.0
Match: 1b7fA_
Description: Sex-lethal protein
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [184-274] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SRERDDMCTL KIMQVNENAD ENSLREELLF PFAPIPRVSV VRNKETGKSR GLAFVTFSSE  60
   61 EVAEQALRFL DGRGYMNLIL RVEWSKPKVK E

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 78.0
Match: 1b7fA_
Description: Sex-lethal protein
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle