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View Structure Prediction Details

Protein: ARO80
Organism: Saccharomyces cerevisiae
Length: 950 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ARO80.

Description E-value Query
Range
Subject
Range
ARO80 - Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic ami...
ARO80_YEAST - Transcriptional activator ARO80 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ARO80 PE...
0.0 [1..950] [1..950]

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Predicted Domain #1
Region A:
Residues: [1-89]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAKKRPSGN AAFELPKRRR TYQACISCRS RKVKCDLGPV DNPHDPPCAR CKRELKKCIF  60
   61 SSNKGTSNDL PPNSINAISL PSLGKSKQE

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 8.95
Match: 1d66A
Description: Gal4; CD2-Gal4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.34861813464065 bayes_pls_golite062009
DNA binding 4.03985756894684 bayes_pls_golite062009
nucleic acid binding 3.97978190843512 bayes_pls_golite062009
transcription factor activity 2.87348461329489 bayes_pls_golite062009
binding 2.82809978070212 bayes_pls_golite062009
sequence-specific DNA binding 2.77469997789536 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.70904317608141 bayes_pls_golite062009
transcription activator activity 2.1512787242583 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 2.08956709478484 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [90-950]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IQNDSTSPIL SDVPLSRKGI SSEKSFKSEG MKWKLELSSM QNALEFLAQA AGTVAKEGAK  60
   61 EIIKEKSTTP KPLKSSLDAT NKSATDEGLK RLSKSDSTNT LYENTADMLN HTLNTNRKTS 120
  121 QLMEEIGKVR PPPTRKIDDF DYIGPDSLLT KEEAIELIEA FFLTMHPFFP NIPLQLHDPK 180
  181 ELAEYPILFC AILTVSARYH PFDTLGLDNG EDGMRHIEVH DKLWVYCQKL ISQTIWAEAS 240
  241 TRSIGTVLAF IIFTEWNPRS IHYKWSDYAN DPELNNVNAR GSKNISTRKD EEGLTGVGAI 300
  301 RRSDRMSWML TGSAVRLAQD MGFIENSSKV FIVTHISETT SAMNMNQRSL LAESFSVLNL 360
  361 NLGKIENDGN ESNEDYLGNE KFYLNEILPD EESKLRWKRV FENSENDHDN EKNFLTDWER 420
  421 EFLNDEYVLY YSNKKDDTNL AQNHIPPFPL RFSFAQRAKI EIIRILSIAY ETIYCEKNKR 480
  481 KLATTDQRHN LSVLSVFSPL IEGWLSNYRE LLVPLSDVPF SLADRKNKKQ IFDNIDRING 540
  541 ESIITDFNYC QLYIFSLALQ VDGKTSRLNM NEIVTSARYV ELAYRSAKEI LSSAKRVSRQ 600
  601 GMLKYMPVRW VIRIIRSIAF IVKCYLTLTG SELATNPDAR NILKLSAISV DETFDIIRDT 660
  661 AVTLKEATPD ELHLCQRYAA ILMYLCTEMK LRKKSYLERP PLLRDGTTPL ESNRESSLEG 720
  721 QDLTKKPIFS KRIGYNKTET TFEPSERPLT EEINSNSQNS NDTSSKGIVD PFVEQNNDIT 780
  781 TALLNNELFQ GPSLSDEVTD WFGASEDIGL EFVEPWTELI EQRYMQCGDG DNNNFENLYN 840
  841 LFVNSNNINN DINNSRPITR K

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [291-415]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FDTLGLDNGE DGMRHIEVHD KLWVYCQKLI SQTIWAEAST RSIGTVLAFI IFTEWNPRSI  60
   61 HYKWSDYAND PELNNVNARG SKNISTRKDE EGLTGVGAIR RSDRMSWMLT GSAVRLAQDM 120
  121 GFIEN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [416-535]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSKVFIVTHI SETTSAMNMN QRSLLAESFS VLNLNLGKIE NDGNESNEDY LGNEKFYLNE  60
   61 ILPDEESKLR WKRVFENSEN DHDNEKNFLT DWEREFLNDE YVLYYSNKKD DTNLAQNHIP 120
  121 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [536-726]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PFPLRFSFAQ RAKIEIIRIL SIAYETIYCE KNKRKLATTD QRHNLSVLSV FSPLIEGWLS  60
   61 NYRELLVPLS DVPFSLADRK NKKQIFDNID RINGESIITD FNYCQLYIFS LALQVDGKTS 120
  121 RLNMNEIVTS ARYVELAYRS AKEILSSAKR VSRQGMLKYM PVRWVIRIIR SIAFIVKCYL 180
  181 TLTGSELATN P

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [727-795]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DARNILKLSA ISVDETFDII RDTAVTLKEA TPDELHLCQR YAAILMYLCT EMKLRKKSYL  60
   61 ERPPLLRDG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [796-865]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TTPLESNRES SLEGQDLTKK PIFSKRIGYN KTETTFEPSE RPLTEEINSN SQNSNDTSSK  60
   61 GIVDPFVEQN 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [866-950]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDITTALLNN ELFQGPSLSD EVTDWFGASE DIGLEFVEPW TELIEQRYMQ CGDGDNNNFE  60
   61 NLYNLFVNSN NINNDINNSR PITRK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle