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View Structure Prediction Details

Protein: ARH1
Organism: Saccharomyces cerevisiae
Length: 493 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ARH1.

Description E-value Query
Range
Subject
Range
gi|1055300 - gi|1055300|gb|AAC49500.1| adrenodoxin oxidoreductase homolog
0.0 [1..493] [1..493]
gi|67515415, gi|... - gi|67515415|gb|AAY68215.1| ferredoxin reductase [Homo sapiens], gi|178208|gb|AAA51668.1| adrenodoxin...
3.0E-94 [6..486] [29..491]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
2.0E-93 [7..486] [30..492]
ADRO_BOVIN - NADPH:adrenodoxin oxidoreductase, mitochondrial OS=Bos taurus GN=FDXR PE=1 SV=3
4.0E-93 [7..486] [30..486]
ADRO_RAT - NADPH:adrenodoxin oxidoreductase, mitochondrial OS=Rattus norvegicus GN=Fdxr PE=1 SV=1
1.0E-90 [6..486] [31..488]

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Predicted Domain #1
Region A:
Residues: [1-124]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFVQIRHIS SQINRKTVSI VGSGPSGFYT AYHLLKKSPI PLNVTIWEKL PVPFGLSRYG  60
   61 VAPDHPEVKN CEETFTTCAE EFSSPTNQKH KFSFVGGITI GKEILLKELL DNQDAVILSY 120
  121 GCTG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [364-466]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YAGVPMPEFS KLSIGFDKDH IANKQGRVLT SSGEIFPHLY ASGWIRKGSQ GVIASTMQDA  60
   61 FEVGDRVIQD LVVSGALSLE NSIDLSNIKH TTWKDWERIN KKE

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [482-493]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TFEELWNGVE GI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 713.616428
Match: 1cjcA_
Description: Adrenodoxin reductase of mitochondrial p450 systems
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
NADPH-adrenodoxin reductase activity 5.80270482091908 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH 4.45434904225178 bayes_pls_golite062009
oxidoreductase activity 2.10828870968712 bayes_pls_golite062009
antioxidant activity 1.49429830917872 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors 1.39990343076756 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors 1.29733355244701 bayes_pls_golite062009
catalytic activity 1.13824203225664 bayes_pls_golite062009
thioredoxin-disulfide reductase activity 0.844975371289313 bayes_pls_golite062009
binding 0.794954996246594 bayes_pls_golite062009
dihydrolipoyl dehydrogenase activity 0.68737141906442 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors 0.379282693663222 bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor 0.31095562417378 bayes_pls_golite062009
oxygen-dependent protoporphyrinogen oxidase activity 0.0706880697754912 bayes_pls_golite062009
protein binding 0.0171008177759692 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [125-363]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DRKLNIPGEL GTKGVFSSRE FVNWYNGHPD FAKDKRFTDF DWSKVSKVGI IGNGNVALDI  60
   61 TRVLISNQID EIWENTDISS LALNLLRRAP VKDVKLIARR DFVHSKFTNK ELRELWELEK 120
  121 YGIRGRIDPK FFQKEMFDPS KYDRAFNRRV EMCSEYLKPF NERSKKNYKK APPPSSGYDK 180
  181 FWELDYLKTP LKINRDDFGA INSLSLCNNR LNEDNSLQPL KDVNNIMTYK VDLLITSLG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [467-481]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLRGKKEHKT RSKFL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 713.616428
Match: 1cjcA_
Description: Adrenodoxin reductase of mitochondrial p450 systems
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle