YRC Public Data Repository - Protein Structure Prediction

Protein:	TRR1
Organism:	Saccharomyces cerevisiae
Length:	319 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TRR1.

Description	E-value	Query Range	Subject Range
TRXB1_YEAST - Thioredoxin reductase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TRR1 PE=1 SV=3 TRR1 - Cytoplasmic thioredoxin reductase, key regulatory enzyme that determines the redox state of the thio... gi\|151942327 - gi\|151942327\|gb\|EDN60683.1\| thioredoxin reductase [Saccharomyces cerevisiae YJM789] gi\|207346401 - gi\|207346401\|gb\|EDZ72908.1\| YDR353Wp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190404710 - gi\|190404710\|gb\|EDV07977.1\| thioredoxin reductase 1 [Saccharomyces cerevisiae RM11-1a]	0.0	[1..319]	[1..319]
TRXB_SCHPO - Thioredoxin reductase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=trr1 PE=1 SV=1 trr1 - thioredoxin reductase Trr1	0.0	[1..319]	[1..319]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[6..317]	[86..393]
gi\|23308231, gi\|... - gi\|23308231\|gb\|AAN18085.1\| At2g41680/T32G6.20 [Arabidopsis thaliana], gi\|15912233\|gb\|AAL08250.1\| At2...	1.0E-99	[6..317]	[86..393]
TRXB_NEUCR - Thioredoxin reductase OS=Neurospora crassa GN=cys-9 PE=3 SV=1 TRXB_NEUCR - Thioredoxin reductase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /...	3.0E-99	[2..319]	[1..318]
TRXB_CHLPN - Thioredoxin reductase OS=Chlamydia pneumoniae GN=trxB PE=3 SV=1 gi\|16752725, gi\|... - gi\|7189366\|gb\|AAF38283.1\| thioredoxin reductase [Chlamydophila pneumoniae AR39], gi\|16752725\|ref\|NP_... gi\|15835849, gi\|... - gi\|8978688\|dbj\|BAA98524.1\| thioredoxin reductase [Chlamydophila pneumoniae J138], gi\|15835849\|ref\|NP... gi\|15618234, gi\|... - gi\|4376591\|gb\|AAD18463.1\| Thioredoxin Reductase [Chlamydophila pneumoniae CWL029], gi\|15618234\|ref\|N... gi\|33236167, gi\|... - gi\|33241658\|ref\|NP_876599.1\| thioredoxin reductase [Chlamydophila pneumoniae TW-183], gi\|33236167\|gb...	1.0E-98	[1..315]	[1..310]
gi\|25285002 - pir\|\|AF2081 thioredoxin reductase [imported] - Nostoc sp. (strain PCC 7120) gi\|17131295, gi\|... - gi\|17229696\|ref\|NP_486244.1\| thioredoxin reductase [Nostoc sp. PCC 7120], gi\|17131295\|dbj\|BAB73903.1...	2.0E-98	[5..317]	[4..311]

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Predicted Domain #1

Region A:
Residues: [1-123]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVHNKVTIIG SGPAAHTAAI YLARAEIKPI LYEGMMANGI AAGGQLTTTT EIENFPGFPD  60
   61 GLTGSELMDR MREQSTKFGT EIITETVSKV DLSSKPFKLW TEFNEDAEPV TTDAIILATG 120
  121 ASA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [250-319]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HTPATKIVAG QVDTDEAGYI KTVPGSSLTS VPGFFAAGDV QDSKYRQAIT SAGSGCMAAL  60
   61 DAEKYLTSLE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1161.09691
Match:	1vdc__
Description:	Thioredoxin reductase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
thioredoxin-disulfide reductase activity	3.42654162439464	bayes_pls_golite062009
antioxidant activity	3.37477730756688	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	3.17769237742078	bayes_pls_golite062009
catalytic activity	1.56773888754354	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	1.45104542724719	bayes_pls_golite062009
binding	1.4227698123368	bayes_pls_golite062009
oxidoreductase activity	0.44090433301056	bayes_pls_golite062009
oxygen-dependent protoporphyrinogen oxidase activity	0.1498172520052	bayes_pls_golite062009
dihydrolipoyl dehydrogenase activity	0.130601418359425	bayes_pls_golite062009
protein binding	0.116927178396589	bayes_pls_golite062009
disulfide oxidoreductase activity	0.0160065137614933	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [124-249]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KRMHLPGEET YWQKGISACA VCDGAVPIFR NKPLAVIGGG DSACEEAQFL TKYGSKVFML  60
   61 VRKDHLRAST IMQKRAEKNE KIEILYNTVA LEAKGDGKLL NALRIKNTKK NEETDLPVSG 120
  121 LFYAIG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1161.09691
Match:	1vdc__
Description:	Thioredoxin reductase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: