YRC Public Data Repository - Protein Structure Prediction

Protein:	FCF1
Organism:	Saccharomyces cerevisiae
Length:	189 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FCF1.

Description	E-value	Query Range	Subject Range
gi\|20197374, gi\|... - gi\|20197374\|gb\|AAC62883.2\| expressed protein [Arabidopsis thaliana], gi\|18407014\|ref\|NP_566068.1\| un...	2.0E-71	[1..188]	[1..188]
FCF1_PONAB - rRNA-processing protein FCF1 homolog OS=Pongo abelii GN=FCF1 PE=2 SV=1 gi\|109084315 - gi\|109084315\|ref\|XP_001088448.1\| PREDICTED: similar to Protein C14orf111 [Macaca mulatta] ENSCJAT00000040286 - null FCF1 - FCF1 small subunit (SSU) processome component homolog (S. cerevisiae) CN111_PONPY, FCF... - rRNA-processing protein FCF1 homolog - Pongo pygmaeus (Orangutan), (Q5RFQ0) Protein C14orf111 homolo... gi\|114653949 - gi\|114653949\|ref\|XP_522906.2\| PREDICTED: hypothetical protein [Pan troglodytes] FCF1_BOVIN - rRNA-processing protein FCF1 homolog OS=Bos taurus GN=FCF1 PE=2 SV=1	1.0E-66	[1..189]	[1..193]
FCF1_YEAST - rRNA-processing protein FCF1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FCF1 PE=1 S... FCF1 - Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRN... gi\|207346429 - gi\|207346429\|gb\|EDZ72923.1\| YDR339Cp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190404720 - gi\|190404720\|gb\|EDV07987.1\| hypothetical protein SCRG_00190 [Saccharomyces cerevisiae RM11-1a]	3.0E-66	[1..189]	[1..189]
gi\|50293957, gi\|... - gi\|50293957\|ref\|XP_449390.1\| hypothetical protein CAGL0M01056g [Candida glabrata CBS138], gi\|4952870... gi\|15667240, gi\|... - gi\|49528704\|emb\|CAG62366.1\| unnamed protein product [Candida glabrata], gi\|15667240\|gb\|AAL02316.1\| Y...	6.0E-66	[1..189]	[1..189]
gi\|12834300 - gi\|12834300\|dbj\|BAB22857.1\| unnamed protein product [Mus musculus]	9.0E-64	[4..189]	[1..190]
FCF1_SCHPO - rRNA-processing protein fcf1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=fcf1 PE=3 SV=... SPBC32H8.04c - rRNA processing protein Fcf1	1.0E-58	[1..188]	[1..190]
gi\|220949042 - gi\|220949042\|gb\|ACL87064.1\| Bka-PA [synthetic construct] Bka-PA - The gene Bekka is referred to in FlyBase by the symbol Dmel\Bka (CG4539, FBgn0010520). It is a prote...	1.0E-56	[1..189]	[1..196]
CE09810 - Yeast D96591.6 protein like status:Confirmed UniProt:Q93638 protein_id:CAB03017.2	9.0E-55	[1..189]	[1..191]

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Predicted Domain #1

Region A:
Residues: [1-189]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKAKKTRKF GLVKRTLNTK KDQRLKKNQE NIKTKEDPEL TRNIPQVSSA LFFQYNQAIK  60
   61 PPYQVLIDTN FINFSIQKKV DIVRGMMDCL LAKCNPLITD CVMAELEKLG PKYRIALKLA 120
  121 RDPRIKRLSC SHKGTYADDC LVHRVLQHKC YIVATNDAGL KQRIRKIPGI PLMSVGGHAY 180
  181 VIEKLPDVF

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Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
DNA binding	3.09371833630908	bayes_pls_golite062009
nucleic acid binding	3.04560439515264	bayes_pls_golite062009
nuclease activity	2.9643999717473	bayes_pls_golite062009
exonuclease activity	2.73966722455965	bayes_pls_golite062009
endodeoxyribonuclease activity	2.32240591300465	bayes_pls_golite062009
deoxyribonuclease activity	2.20319910135606	bayes_pls_golite062009
binding	2.06833406478856	bayes_pls_golite062009
flap endonuclease activity	1.93047867791632	bayes_pls_golite062009
endonuclease activity	1.76157945742159	bayes_pls_golite062009
5'-3' exonuclease activity	1.66809858159343	bayes_pls_golite062009
protein binding	1.53930087292625	bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1.5104333947608	bayes_pls_golite062009
catalytic activity	1.37534898662234	bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	1.24621366977274	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	1.0761952249864	bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters	0.756864776606945	bayes_pls_golite062009
exodeoxyribonuclease activity	0.74826759322705	bayes_pls_golite062009
3'-5' exonuclease activity	0.50487165366129	bayes_pls_golite062009
5'-3' exodeoxyribonuclease activity	0.34527101309477	bayes_pls_golite062009
double-stranded DNA specific exodeoxyribonuclease activity	0.123105804280941	bayes_pls_golite062009
single-stranded DNA specific exodeoxyribonuclease activity	0.120278857913627	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: