YRC Public Data Repository - Protein Structure Prediction

Protein:	SWA2
Organism:	Saccharomyces cerevisiae
Length:	668 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SWA2.

Description	E-value	Query Range	Subject Range
SWA2 - Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoatin... SWA2_YEAST - Auxilin-like clathrin uncoating factor SWA2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c)... gi\|151942295 - gi\|151942295\|gb\|EDN60651.1\| conserved protein [Saccharomyces cerevisiae YJM789]	0.0	[1..668]	[1..668]
ucp7 - UBA /TPR /DNAJ domain protein Ucp7 UCP7_SCHPO - UBA domain-containing protein 7 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ucp7 PE=3 ...	2.0E-68	[3..667]	[54..697]
TTL3_ARATH - Inactive TPR repeat-containing thioredoxin TTL3 OS=Arabidopsis thaliana GN=TTL3 PE=1 SV=2	8.0E-58	[82..621]	[199..673]
gi\|25461543, gi\|... - pir\|\|T51996 hypothetical protein stil+ - fission yeast (Schizosaccharomyces pombe), gi\|2506064\|dbj...	4.0E-55	[2..575]	[43..571]
gi\|17228384, gi\|... - gi\|17228384\|ref\|NP_484932.1\| hypothetical protein all0889 [Nostoc sp. PCC 7120], gi\|17130234\|dbj\|BAB... gi\|25532833 - pir\|\|AF1917 hypothetical protein all0889 [imported] - Nostoc sp. (strain PCC 7120)	2.0E-54	[116..666]	[15..590]
gi\|13775066 - gi\|13775066\|gb\|AAK39123.1\|AF363030_1 UDP-N-acetylglucosaminyltransferase [Mus musculus]	2.0E-51	[269..633]	[81..461]
OGT1_RAT - UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Rattus norvegicu...	3.0E-51	[269..633]	[71..451]

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Predicted Domain #1

Region A:
Residues: [1-352]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDPFAHLLT SLKNKDSASA SKETTPQSSN SPSITGSAVA DVARTDKSPN DSLHSISAPP  60
   61 LIPSPKVDFS APPLVPTNST TKSNTANNTP PSALANTDDD FNQLFGMGTV TTTDTIQKPD 120
  121 EDYYGSKEDH LYNGDDALVD EVKDMEIARL MSLGLSIEEA TEFYENDVTY ERYLEILKSK 180
  181 QKERNDLAIR KKESGIKMEK SGLSNIVGTD SNNLFSMATD FFNKGKKLVD QWTSFPPEAN 240
  241 DRLNNYSKTH DKVEDYDLPQ VNDSPNRILF EDNEVVENLP PADNPDQDLL TDFETKIDIT 300
  301 KRTAPDVSHS SSPTSGILIE ENSRRNEPLI EDSLLDFSEG NLTNSKSNED ST

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [353-543]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LFNENSNTDS TIPISDIELS GYNEFKAKGT SLFKNGDYIN SLQEYEKSLN TLPLNHPLRI  60
   61 IALSNIIASQ LKIGEYSKSI ENSSMALELF PSSKAKWKNK ISNSDPERSF NDIWPKIMIR 120
  121 RAESFEHLES FKKALETYQE LIKKNFFDDK IMQGKRRCQD FINPPPVKKS MPVKKKTTTT 180
  181 SPATKKQNLT A

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	52.70927
Match:	1elwA_
Description:	Hop
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [544-598]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSNSPISVD STSEIKKREL ENAKLALYDK VFEKISSWKD GKDDDIRHLL ANLSS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
binding	2.0541759325193	bayes_pls_golite062009
protein binding	1.81676109739118	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [599-668]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLTWCNWKDV SMQDLVMPKR VKITYMKAVA KTHPDKIPES LSLENKMIAE NIFSTLSIAW  60
   61 DKFKLQNDIN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	4.522879
Match:	1xbl__
Description:	DnaJ chaperone, N-terminal (J) domain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: