YRC Public Data Repository - Protein Structure Prediction

Protein:	PEX10
Organism:	Saccharomyces cerevisiae
Length:	337 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PEX10.

Description	E-value	Query Range	Subject Range
PEX10_YEAST - Peroxisome biogenesis factor 10 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PEX10 PE... PEX10 - Peroxisomal membrane E3 ubiquitin ligase required for for Ubc4p-dependent Pex5p ubiquitination and p... gi\|207346521 - gi\|207346521\|gb\|EDZ72995.1\| YDR265Wp-like protein [Saccharomyces cerevisiae AWRI1631] gi\|190404787 - gi\|190404787\|gb\|EDV08054.1\| C3HC4 zinc-binding integral peroxisomal membrane protein [Saccharomyces ...	1.0E-81	[1..337]	[1..337]
PEX10_ARATH - Peroxisome biogenesis factor 10 OS=Arabidopsis thaliana GN=PEX10 PE=1 SV=1	5.0E-60	[19..336]	[25..377]
gi\|50547683, gi\|... - gi\|50547683\|ref\|XP_501311.1\| YALI0C01023p [Yarrowia lipolytica], gi\|49647178\|emb\|CAG81606.1\| YALI0C0... gi\|9049374, gi\|4... - gi\|9049374\|dbj\|BAA99413.1\| PEX10 [Yarrowia lipolytica], gi\|49647178\|emb\|CAG81606.1\| YALI0C01023p [Ya...	1.0E-58	[19..336]	[43..377]
PEXA_PICAN, PEX1... - (Q00940) Peroxisome assembly protein PER8 (Peroxin-10), Peroxisome biogenesis factor 10 OS=Pichia an... PEX10_PICAN - Peroxisome biogenesis factor 10 OS=Pichia angusta GN=PEX10 PE=3 SV=1	1.0E-57	[20..336]	[5..295]
PEX10 - peroxisomal biogenesis factor 10	5.0E-53	[23..336]	[6..323]
PEX10_PICPA - Peroxisome biogenesis factor 10 OS=Komagataella pastoris GN=PEX10 PE=1 SV=1	2.0E-48	[20..319]	[23..331]
gi\|220953698, gi... - gi\|220953698\|gb\|ACL89392.1\| CG7864-PA [synthetic construct], gi\|220943852\|gb\|ACL84469.1\| CG7864-PA [... FBpp0305589, CG7... - This gene is referred to in FlyBase by the symbol Dmel\CG7864 (CG7864, FBgn0035233). It is a protein...	4.0E-47	[23..333]	[8..293]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	2.0E-41	[66..336]	[1..306]

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Predicted Domain #1

Region A:
Residues: [1-101]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKNDNKLQKE ALMRLSQLRF PFADAPSIVQ AHQKDEQIQG LLIMKVTELC KLIKSQLFVN  60
   61 SYPKELSIFA KLLYLLFTTG RRGRTLGEEY VDLTYTNRKG T

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.888	0.336	peroxisomal membrane	a.45.1	Glutathione S-transferase (GST), C-terminal domain

Predicted functions:

Term	Confidence	Notes
nucleic acid binding	1.94188352248723	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [102-285]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RLAGRLKMIV FAFAYPLCPY FITKLYKKIM KNNKESKIED TESVAAFCKG LLDFILDVHM  60
   61 TLFYFKGAFY SISKRIFGMR YVFKHILSKN EANFREEGSQ KYKVLGYILL AQNVMKWYPV 120
  121 LTSTLGSWIY GRKRTNDSIT RSSVGLQERS EHESIEGIPK ESQLTHINLS DKNQLPFIPE 180
  181 ASRK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	77.24799
Match:	1fbvA_
Description:	Cbl; N-terminal domain of cbl (N-cbl); CBL
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [286-337]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CILCLMNMSD PSCAPCGHLF CWSCLMSWCK ERPECPLCRQ HCQPQEILVL RQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	77.24799
Match:	1fbvA_
Description:	Cbl; N-terminal domain of cbl (N-cbl); CBL
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: